Apoptosis of CD34+ cells after incubation with sera of leukopenic patients with systemic lupus erythematosus

Lupus

Volumn 12, Issue 6, 2003, Pages 471-478

  Tiefenthaler, Martin ^a,d   Bacher, N ^a   Linert, H ^a   Muhlmann O ^a   Hofer, S ^b   Sepp, N ^b   Amberger, A ^c   Geisen, F ^a   Obermoser, G ^b   Konwalinka, G ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c TYROLEAN CANCER RESEARCH INSTITUTE   (Austria)

^d INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Apoptosis; Immunoglobulin independent; Leukopenia; Stem cels; Systemic lupus erythematosus

Indexed keywords

ALPHA INTERFERON; ANTINUCLEAR ANTIBODY; CD34 ANTIGEN; DNA ANTIBODY; DOUBLE STRANDED DNA; FAS ANTIGEN; HEMOGLOBIN; IMMUNOGLOBULIN G; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANEMIA; ANTIBODY TITER; APOPTOSIS; ARTICLE; BLOOD CELL; BONE MARROW; CELL COUNT; CELL PROLIFERATION; CELLULAR IMMUNITY; CLINICAL ARTICLE; COMPLEMENT INHIBITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HEMATOPOIESIS; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; LEUKOPENIA; MALE; PRIORITY JOURNAL; STEM CELL; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANTIGENS, CD34; APOPTOSIS; BONE MARROW CELLS; CELLS, CULTURED; HEMATOPOIESIS; HUMANS; IN SITU NICK-END LABELING; INTERFERON-ALPHA; LEUKOPENIA; LUPUS ERYTHEMATOSUS, SYSTEMIC; SENSITIVITY AND SPECIFICITY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037931552     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1191/0961203303lu423oa     Document Type: Article

References (22)

1. Yamasaki K, Niho Y, Yanase T. Granulopoiesis in systemic lupus erythematosus. Arthritis Rheum 1983; 26: 516-521.
2. Steinberg AD, Gourley MF, Klinman DM, Tsokos GC, Scott DE, Krieg AM. NIH conference. Systemic lupus erythematosus. Ann Intern Med 1991; 115: 548-559.
3. Fitchen JJ, Cline MJ, Saxon A, Golde DW. Serum inhibitors of hematopoiesis in a patient with aplastic anemia and systemic lupus erythematosus. Recovery after exchange plasmapheresis. Am J Med 1979; 66: 537-542.
4. Bailey FA, Lilly M, Bertoli LF, Ball GV. An antibody that inhibits in vitro bone marrow proliferation in a patient with systemic lupus erythematosus and aplastic anemia. Arthritis Rheum 1989; 32: 901-905.
5. Liu H, Ozaki K, Matsuzaki Y, Abe M, Kosaka M, Saito S. Suppression of haematopoiesis by IgG autoantibodies from patients with systemic lupus erythematosus (SLE). Clin Exp Immunol 1995; 100: 480-485.
6. Hellmich B, Csernok E, Schatz H, Gross WL, Schnabel A. Autoantibodies against granulocyte colony-stimulating factor in Felty's syndrome and neutropenic systemic lupus erythematodes. Arthritis Rheum 2002; 46: 2384-2391.
7. Papadaki HA, Boumpas DT, Gibson FM, Jayne DR, Axford JS, Gordon-Smith EC, Marsh JC, Eliopoulos GD. Increased apoptosis of bone marrow CD34(+) cells and impaired function of bone marrow stromal cells in patients with systemic lupus erythematosus. Br J Haematol 2001; 115: 167-174.
8. Josefsen D, Blomhoff HK, Lomo J, Blystad AK, Smeland EB. Retinoic acid induces apoptosis of human CD34+ hematopoietic progenitor cells: involvement of retinoic acid receptors and retinoid X receptors depends on lineage commitment of the hematopoietic progenitor cells. Exp Hematol 1999; 27: 642-653.
9. Strater J, Walczak H, Hasel C, Melzner I, Leithauser F, Moller P. CD95 ligand (CD95L) immunohistochemistry: a critical study on 12 antibodies. Cell Death Differ 2001; 8: 273-278.
10. Wang H, Grand RJ, Milner AE, Armitage RJ, Gordon J, Gregory CD. Repression of apoptosis in human B-lymphoma cells by CD40-ligand and Bcl-2: relationship to the cell-cycle and role of the retinoblastoma protein. Oncogene 1996; 13: 373-379.
11. Blanco P, Palucka AK, Gill M, Pascual V, Banchereau J. Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science 2001; 294: 1540-1543.
12. Davas EM, Tsirogianni A, Kappou I, Karamitsos D, Economidou I, Dantis PC. Serum IL-6, TNFalpha, p55srTNFalpha, p75srTNFalpha, srIL-2alpha levels and disease activity in systemic lupus erythematosus. Clin Rheumatol 1999; 18: 17-22.
13. Jones BM, Liu T, Wong RW. Reduced in vitro production of interferon-gamma, interleukin-4 and interleukin-12 and increased production of interleukin-6, interleukin-10 and tumour necrosis factor-alpha in systemic lupus erythematosus. Weak correlations of cytokine production with disease activity. Autoimmunity 1999; 31: 117-124.
14. Nozawa K, Kayagaki N, Tokano Y, Yagita H, Okumura K, Hasimoto H. Soluble Fas (APO-1, CD95) and soluble Fas ligand in rheumatic diseases. Arthritis Rheum 1997; 40: 1126-1129.
15. Tokano Y, Miyake S, Kayagaki N et al. Soluble Fas molecule in the serum of patients with systemic lupus erythematosus. J Clin Immunol 1996; 16: 261-265.
16. Maciejewski JP, Selleri C, Sato T, Anderson S, Young NS. Increased expression of Fas antigen on bone marrow CD34+ cells of patients with aplastic anaemia. Br J Haematol 1995; 91: 245-252.
17. Claessens YE, Bouscary D, Dupont JM et al. In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: evidence for Fas-dependent apoptosis. Blood 2002; 99: 1594-1601.
18. Kim H, Whartenby KA, Georgantas RW, III, Wingard J, Civin CI. Human CD34+ hematopoietic stem/progenitor cells express high levels ofFLIP and are resistant to Fas-mediated apoptosis. Stem Cells 2002; 20: 174-182.
19. Miret C, Font J, Molina R et al. Relationship of oncogenes (sFas, Bcl-2) and cytokines (IL-10, alfa-TNF) with the activity of systemic lupus erythematosus. Anticancer Res 2001; 21: 3053-3059.
20. Robak T, Korycka A, Gora-Tybor J, Piotrowska-Wrzesien A, Krykowski E. The influence of recombinant human tumor necrosis factor (rh-TNF alpha) on granulocyte-macrophage progenitor cells (CFU-GM) and clonogenic leukaemic blasts (CFU-L) in cultures in vitro. Arch Immunol Ther Exp (Warsz) 1992; 40: 339-343.
21. Papadaki HA, Kritikos HD, Valatas V, Boumpas DT, Eliopoulos GD. Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells: improvement following anti-tumor necrosis factor-alpha antibody therapy. Blood 2002; 100: 474-482.
22. Courtney PA, Crockard AD, Williamson K, Irvine AE, Kennedy RJ, Bell AL. Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: relations with disease activity, antibodies to double stranded DNA, and neutropenia. Ann Rheum Dis 1999; 58: 309-314.