Loperamide mobilizes intracellular Ca 2+ stores in insulin-secreting HIT-T15 cells

British Journal of Pharmacology

Volumn 139, Issue 2, 2003, Pages 351-361

  He, Li Ping ^a   Mears, David ^b   Atwater, Illani ^c   Rojas, Eduardo ^c   Cleemann, Lars ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b USU School of Medicine   (United States)

^c UNIVERSITY OF CHILE   (Chile)

Author keywords

Ca 2+ activated K + channel; Charybdotoxin; Endoplasmic reticulum; Ion channels; IP 3 gated stores; Patch clamp; Stimulus secretion coupling; Thimerosal

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE INHIBITOR; ADENOSINE TRIPHOSPHATE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ION; CARBACHOL; INSULIN; LOPERAMIDE; MUSCARINIC AGENT; POTASSIUM CHANNEL; THAPSIGARGIN; TOLBUTAMIDE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL MEMBRANE POTENTIAL; CONCENTRATION RESPONSE; CONDUCTANCE; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIVITY; ENDOPLASMIC RETICULUM; EXTRACELLULAR CALCIUM; INSULIN RELEASE; INSULINOMA; MEMBRANE CURRENT; NONHUMAN; PANCREAS ISLET BETA CELL; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL;

ANIMALS; CALCIUM; CALCIUM CHANNELS; CARBACHOL; CELL LINE, TUMOR; CHARYBDOTOXIN; CRICETINAE; INSULIN; INSULINOMA; ISLETS OF LANGERHANS; LOPERAMIDE; MUSCARINIC AGONISTS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 0037930518     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705263     Document Type: Article

References (59)

1. + conductance in glucose-stimulated pancreatic β-cells. Nature, 353, 849-852.
2. ASHCROFT, F.M., ASHCROFT, S.J.H. & HARRISON, D.E. (1988). Properties of single potassium channels modulated by glucose in rat pancreatic β-cells. J. Physiol., 400, 501-527.
3. ASHCROFT, F.M., HARRISON, D.E. & ASHCROFT, S.J.H. (1984). Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells. Nature, 312, 446-448.
4. ATWATER, I., DAWSON, C.M., RIBALET, B. & ROJAS, E. (1979). Potassium permeability activated by intracellular calcium ion concentration in the pancreatic beta-cell. J. Physiol., 288, 575-588.
5. ATWATER, I., RIBALET, B. & ROJAS, E. (1978). Cyclic changes in potential and resistance of the beta-cell membrane induced by glucose in islets of Langerhans from mouse. J. Physiol., 278, 117-139.
6. + channel in pancreatic beta-cells. Cell Calcium, 4, 451-461.
7. AWOUTERS, F., NIEMEGEERS, J.E. & JANSSEN, P.A.J. (1983). Pharmacology of antidiarrheal drugs. Annu. Rev. Pharmacol. Toxicol., 23, 279-301.
8. BERTRAM, R., SMOLEN, P., SHERMAN, A., MEARS, D., ATWATER, I., MARTIN, F. & SORIA, B. (1995). A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells. Biophys. J., 68, 2323-2332.
9. BODE, H.P. & GOKE, B. (1994). Protein kinase C activates capacitative calcium entry in the insulin secreting cell line RINm5F. FEBS Lett., 339, 307-311.
10. BORDIN, S., BOSCHERO, A.C., CARNEIRO, E.M. & ATWATER, I. (1995). Ionic mechanisms involved in the regulation of insulin secretion by muscarinic agonists. J. Membr. Biol., 148, 177-184.
11. BURLEIGH, D.E. (1988). Opioid and non-opioid actions of loperamide on cholinergic nerve function in human isolated colon. Eur. J. Pharmacol., 152, 39-46.
12. 2+ in mouse pancreatic beta-cells. J. Physiol., 485, 607-617.
13. CHURCH, J., FLCTCHER, E.J., ABDEL-HAMID, K. & MACDONALD, J.F. (1994). Loperamide blocks high-voltage-activated calcium channels and N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal. Mol. Pharmacol., 45, 747-757.
14. 2+ transients and contraction. J. Physiol., 432, 283-312.
15. 2+ release sites in rat cardiac myocytes. Proc. Natl. Acad. Sci. U.S.A., 95, 10984-10989.
16. + channels in pancreatic B-cells. Nature, 311, 271-273.
17. + channels in pancreatic β-cells. Nature (London), 311, 269-271.
18. DALY, J.W. & HARPER, J. (2000). Loperamide: novel effects on capacitative calcium influx. Cell Mol. Life Sci., 57, 149-157.
19. DALY, J.W., LUEDERS, J., PADGETT, W.L., SHIN, Y. & GUSOVSKY, F. (1995). Maitotoxin-elicited calcium influx in cultured cells. Effect of calcium-channel blockers. Biochem. Pharmacol., 50, 1187-1197.
20. 2+ and the ATP/ADP ratio: a feedback control mechanism in mouse pancreatic islets. Biochem. J., 333, 269-274.
21. 2+- or cAMP-mediated secretion in rat codon. Eur. J. Pharmacol., 152, 217-225.
22. DING W.G., HE, L.P., OMATSU-KANBE M. & KITASATO, H. (1996). A possible role of the ATP-sensitive potassium ion channel in determining the duration of spike-bursts in mouse pancreatic beta-cells. Biochim. Biophys. Acta, 1279, 219-226.
23. EDDLESTONE, G.T., RIBALET, B. & CIANI, S. (1989). Comparative study of K channel behavior in β cell lines with different secretory responses to glucose. J. Membr. Biol., 109, 123-134.
24. + channel in pancreatic islet cells can be activated and inactivated by internal calcium. J. Membr. Biol., 83, 169-175.
25. GIAGNONI, G., CASIRAGHI, L., SENINI, R. REVEL, L., PAROLARO, D., SALA, M. & GORI, E. (1983) Loperamide: evidence of interaction with mu and delta opioid receptors. Life Sci., 33, 315-318.
26. + channels contributes to rhythmic firing of action potentials in mouse pancreatic β cells. J. Gen. Physiol., 114, 759-770.
27. 2+ in clonal insulin-releasing cells. Evidence for an opposing effect of muscarinic-receptor activation. Biochem. J., 233, 865-870.
28. HARPER, J.L., SHIN, Y. & DALY, J.W. (1997). Loperamide: a positive modulator for store-operated calcium channels? Proc. Natl. Acad. Sci. U.S.A., 94, 14912-14917.
29. 2+/calmodulin-dependent pathway in mouse pancreatic β-cells. J. Membr. Biol., 166, 237-244.
30. HENQUIN, J.C. & MEISSNER, H.P. (1984). Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic β-cells. Experientia, 40, 1043-1052.
31. KATP: an inward rectifier subunit plus the sulfonylurea receptor. Science, 270, 1166-1170.
32. LI, Z.W., DING, J.P., KALYANARAMAN, V. & LINGLE, C.J. (1999). RINm5f cells express inactivating BK channels whereas HIT cells express noninactivating BK Channels. J. Neurophysiol., 81, 611-624.
33. 2+ release in HSG cells. Am. J. Physiol., 275, C571-C580.
34. 2+ entry in insulin-releasing pancreatic beta-cells. Cell Calcium, 22, 277-286.
35. MAECHLER, P., KENNEDY, E.D., SEBO, E., VALEVA, A., POZZAN, T. & WOLLHEIM, C.B. (1999). Secretagogues modulate the calcium concentration in the endoplasmic reticulum of insulin-secreting cells. Studies in aequorin-expressing intact and permeabilized ins-1 cells. J. Biol. Chem., 274, 12583-12592.
36. MARTY, A. & NEHER, E. (1982). Ionic channels in cultured rat pancreatic beta cells. J. Physiol., 326, 36P-37P.
37. MATHIAS, P.C., CARPINELLI, A.R., BILLAUDEL, B., GARCIA-MORALES, P., VALVERDE, I. & MALAISSE, W.J. (1985). Cholinergic stimulation of ion fluxes in pancreatic islets. Biochem. Pharmacol., 34, 3451-3457.
38. MIHAI, R., LAI, T., SCHOFIELD G. & FARNDON, J.R. (1999). Thimerosal increases the responsiveness of the calcium receptor in human parathyroid and rMTC6-23 cells. Cell Calcium, 26, 95-101.
39. MISLER, S., FALKE, L.C., GILLIS, K. & MCDANIEL, M.L. (1986). A metabolite-regulated potassium channel in rat pancreatic B cells. Proc. Natl. Acad. Sci. U.S.A., 83, 7119-7123.
40. 2+ entry in mouse pancreatic beta-cells by both direct and indirect mechanisms. J. Physiol., 503, 387-398.
41. MORGAN, N.G., RUMFORD, G.M. & MONTAGUE, W. (1985). Studies on the mechanism by which melittin stimulates insulin secretion from isolated rat islets of Langerhans. Biochim. Biophys. Acta, 845, 526-532.
42. 86rubidium efflux from mouse pancreatic islets. FEBS Lett., 176, 457-461.
43. OOMS, L.A.A., DEGRYSE, A. & JANSSEN, P.A.J. (1984). Mechanisms of action of loperamide. Scand. J. Gastroenterol. Suppl., 96, 145-155.
44. 2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol. Rev., 67, 1185-1248.
45. REYNOLDS, I.J., GOULD, R.J. & SNYDER, S.H. (1984). Loperamide: blockade of calcium channels as a mechanism for antidiarrheal effects. J. Pharmacol. Exp. Therap., 31, 628-632.
46. ROE, M.W., LANCASTER, M.E., MERTZ, R.J., WORLEY III, J.F., DUKES, I.D. (1993). Voltage-dependent intracellular calcium release from mouse islets stimulated by glucose. J. Biol. Chem., 268, 9953-9956.
47. 2+ sequestration in diabetic mouse islets of Langerhans. J. Biol. Chem., 269, 18279-18282.
48. i oscillations in transgenically derived beta-cells. J. Biol. Chem., 273, 10402-10410.
49. RORSMAN, P. & TRUBE, G. (1986). Calcium and delayed potassium currents in mouse pancreatic beta-cells under voltage-clamp conditions. J. Physiol., 374, 531-550.
50. +-channels in pancreatic β-cells are regulated by intracellular ATP. Pflügers Arch., 405, 305-309.
51. + channels in rat pancreatic islet β cells: permeation, gating and blockade by cations. Biochim. Biophys. Acta, 982, 62-72.
52. 2+ stores in individual pancreatic beta-cells permeabilized or not with digitonin or alpha-toxin. Cell Calcium, 27, 43-51.
53. 2+ in the endoplasmic reticulum of mouse pancreatic beta cells. J. Biol. Chem., 274, 36883-36890.
54. THASTRUP, O., DAWSON, A.P., SCHARFF, O., FODER, B., CULLEN, P.J., DROBAK, B.K., BYERRUM, P.J., CHRISTENSEN, S.B. & HANLEY, M.R. (1989). Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage. Agents Actions, 43, 187-193.
55. 2+ release in calsequestrin-overexpressing mouse cardiomyocytes. J. Physiol., 524, 399-414.
56. WOLLHEIM, C.B. & SHARP, G.W.G. (1981). Regulation of insulin release by calcium. Physiol. Rev., 61, 914-973.
57. 2+ stores activates a maitotoxin-sensitive nonselective cationic current in beta-cells. J. Biol. Chem., 269, 32055-32058.
58. ZAVECZ, J.H., JACKSON, T.E., LIMP, G.L. & YELLIN, T.O. (1982). Relationship between anti-diarrheal activity and binding to calmodulin. Eur. J. Pharmacol., 78, 375-377.
59. + channels in pancreatic beta-cells is not mediated by cAMP. Pflugers Arch., 411, 613-619.