What more can be provided for the medical management of angina?

Dialogues in Cardiovascular Medicine

Volumn 7, Issue 2, 2002, Pages 101-105

  Marzilli, Mario ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

Adenosine; Angina; Metabolic treatment; Metabolism; Myocardial infarction; Trimetazidine

Indexed keywords

ACETYL COENZYME A ACYLTRANSFERASE; ACETYLSALICYLIC ACID; ACYLTRANSFERASE INHIBITOR; ADENOSINE; ANTILIPEMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARNITINE; DILTIAZEM; ETOMOXIR; FATTY ACID; GLUCOSE; INSULIN; NIFEDIPINE; NITRIC ACID DERIVATIVE; POTASSIUM; PROPRANOLOL; RANOLAZINE; TRIMETAZIDINE;

ANGINA PECTORIS; ARTICLE; CLINICAL TRIAL; CORONARY ARTERY BLOOD FLOW; CORONARY REPERFUSION; DISEASE CONTROL; DRUG EFFICACY; DRUG TOLERANCE; ENERGY METABOLISM; EXERCISE; HEART DEATH; HEART FUNCTION; HEART INFARCTION; HEART LEFT VENTRICLE; HEART PROTECTION; HEMODYNAMICS; HUMAN; HYPERLIPIDEMIA; ISCHEMIC HEART DISEASE; LIFESTYLE; MICROCIRCULATION; PATHOGENESIS; PRESCRIPTION; PRIMARY PREVENTION; REPERFUSION INJURY; REVASCULARIZATION; SIDE EFFECT; SMOKING CESSATION; TRANSLUMINAL CORONARY ANGIOPLASTY;

EID: 0037928897     PISSN: 12729949     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Gibbons RJ, Chatterjee K, Daley J, et al. ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology / American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Chronic Stable Angina. J Am Coll Cardiol. 1999;33:2092-2197.
2. Task Force of the European Society of Cardiology. Management of stable angina pectoris: recommendations of the Task Force of the European Society of Cardiology. Eur Heart J. 1997;18:394-413.
3. Jackson G. Stable angina: maximal medical therapy is not the same as optimal medical therapy. Int J Clin Pract. 2000;54:351.
4. Jackson G. Combination therapy in angina: a review of combined haemodynamic treatment and the role for combined haemodynamic and cardiac metabolic agents. Int J Clin Pract. 2001;55:256-261.
5. Dargie HJ, Ford I, Fox M, on behalf of the Total Ischemic Burden European Trial (TIBET) group. Effects of ischaemia and treatment with atenolol, nifedipine SR and their combination on outcome in patients with chronic stable angina. The TIBET Study Group. Eur Heart J. 1996;17:104-112.
6. Savonitto S, Ardissino D, Egstrup K, et al, on behalf of the International Multicenter AnGina Exercise (IMAGE) Study Group. Combination therapy with metoprolol and nifedipine versus monotherapy, in patients with stable angina pectoris. J Am Coll Cardiol. 1996;27:311-316.
7. Ferguson JD, Ormerod O, Lenox, Smith AJ. Bisoprolol alone and in combination with amlodipine or nifedipine in the treatment of chronic stable angina. Int J Clin Pract. 2000;54:360-363.
8. Pepine CJ. Editorial. J Am Coll Cardiol. 1994;74:226-231.
9. Hemingway H, Crook AM, Feder G, et al. Underuse of revascularization procedures in patients considered appropriate candidates for revascularization. N Engl J Med. 2001;344:645-654.
10. Marzilli M. Management of ischemic heart disease in diabetic patients. Is there a role for cardiac metabolic agents? Curr Med Res Opin. 2001;17:1-6.
11. Marzilli M, Orsini E, Marraccini P, Testa R. Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty. Circulation. 2000;101:2154-2159.
12. McClellan KJ, Plosker GL. Trimetazidine. A review of its use in stable angina pectoris and other coronary conditions. Drugs. 1999;58:143-157.
13. Kantor P, Lucien A, Kozak R, Lopaschuk G. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2000;86:580-588.
14. Stanley WC. Cardiac energetics during ischemia and the rationale for metabolic interventions. Coron Artery Dis. 2001;12(suppl 1):S3-S7.
15. Lopaschuck GD. Optimizing cardiac energy metabolism: how can fatty acid and carbohydrate metabolism be manipulated? Coron Artery Dis. 2001;12(suppl 1):S8-S11.
16. Sentex E, Sergiel JP, Lucien A, Grynberg A. Trimetazidine increases phospholipid turnover in ventricular myocyte. Mol Cell Biochem. 1997;175:153-162.
17. Detry JM. Clinical features of an anti-anginal drug in angina pectoris. Eur Heart J. 1993;14:18-24.
18. Sellier P. The effects of trimetazidine on ergometric parameters in exercise-induced angina. Controlled multicenter double-blind versus placebo study. Arch Mal Coeur Vaiss. 1986;9:1331-1136.
19. Passeron J. Effectiveness of trimetazidine in stable effort angina due to chronic coronary insufficiency. A double-blind versus placebo study. Presse Med. 1986;35:1775-1778.
20. Dalla Volta S, Maraglino G, della Valentina P, Viena P, Desideri A. Comparison of trimetazidine with nifedipine in effort angina: a double-blind crossover study. Cardiovasc Drugs Ther. 1990;4:853-860.
21. Détry JM, Sellier P, Pennaforte S, Cokkinos D, Dargie H, Mathes P. Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients with stable angina. Br J Clin Pharmacol. 1994;37:279-288.
22. Monpère C, Brochier M, Demange J, Ducloux G, Warin JF. Combination of trimetazidine with nifedipine in effort angina. Cardiovasc Drugs Ther. 1990;4:824-825.
23. Michaelides AP, Vyssoulis GP, Bonoris PE, Psaros TK, Papadopoulos PD, Toutouzas PK. Beneficial effects of trimetazidine in men with stable angina under beta-blocker treatment. Curr Ther Res. 1989;46:565-576.
24. Michaelides AP, Spiropoulos K, Dimopoulos K, Athanasiades D, Toutouzas P. Antianginal efficacy of the combination of trimetazidine-propranolol compared with isosorbide dinitrate-propranolol in patients with stable angina. Clin Drug Invest. 1997;13:8-14.
25. Levy S, and the Group of South of France Investigators. Combination therapy of trimetazidine with diltiazem in patients with coronary artery disease. Am J Cardiol. 1995;76:12B-16B.
26. Manchanda SC, Krishnaswami S. Combination treatment with trimetazidine and diltiazem in stable angina pectoris. Heart. 1997;78:353-357.
27. Szwed H, Sadowski Z, Elikowski W, et al. Combination treatment of stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). Eur Heart J. 2001;22:2267-2274.
28. Lu C, Dubrowski P, Fragasso G, Chierchia S. Effects of trimetazidine on ischemic left ventricular dysfunction in patients with coronary artery disease. Am J Cardiol. 1998;82:898-901.
29. Belardinelli R, Purcaro A. Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischemic cardiomyopathy. Eur Heart J. 2001;22:2164-2170.