Innervation of the detrusor muscle bundle in neurogenic detrusor overactivity

BJU International

Volumn 91, Issue 7, 2003, Pages 702-710

  Drake, M J ^a,b,d   Gardner, B P ^c   Brading, A F ^b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c STOKE MANDEVILLE HOSPITAL   (United Kingdom)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Denervation; Human bladder; Serial sectioning

Indexed keywords

ELASTIN; VIMENTIN;

ADULT; ARTICLE; BLADDER DYSFUNCTION; CADAVER; CLINICAL ARTICLE; CONNECTIVE TISSUE; CONTROLLED STUDY; DENERVATION; DETRUSOR MUSCLE; FEMALE; FROZEN SECTION; GANGLION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE INNERVATION; NEUROGENIC DETRUSOR OVERACTIVITY; ORGAN DONOR; PRIORITY JOURNAL; SPINAL CORD INJURY; STAINING; TISSUE SECTION; TRICHOME;

ADULT; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE, SMOOTH; URINARY BLADDER; URINARY BLADDER, NEUROGENIC; URODYNAMICS;

EID: 0037906579     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-410X.2003.04186.x     Document Type: Article

References (19)

1. Gosling JA, Dixon JS. Structure of trabeculated detrusor smooth muscle in cases of prostatic hypertrophy. Urol Int 1980; 35: 351-5
2. Charlton RG, Morley AR, Chambers P, Gillespie JI. Focal changes in nerve, muscle and connective tissue in normal and unstable human bladder. BJU Int 1999; 84: 953-60
3. Mills IW, Greenland JE, McMurray G et al. Studies of the pathophysiology of idiopathic detrusor instability: the physiological properties of the detrusor smooth muscle and its pattern of innervation. J Urol 2000; 163: 646-51
4. Drake MJ, Hedlund P, Mills IW et al. Structural and functional denervation of human detrusor after spinal cord injury. Laboratory Invest 2000; 80: 1491-9
5. German K, Bedwani J, Davies J, Brading AF, Stephenson TP. Physiological and morphometric studies into the pathophysiology of detrusor hyperreflexia in neuropathic patients. J Urol 1995; 153: 1678-83
6. Harrison SC, Hunnam GR, Farman P, Ferguson DR, Doyle PT. Bladder instability and denervation in patients with bladder outflow obstruction. Br J Urol 1987; 60: 519-22
7. Speakman MJ, Brading AF, Gilpin CJ, Dixon JS, Gilpin SA, Gosling JA. Bladder outflow obstruction - a cause of denervation supersensitivity. J Urol 1987; 138: 1461-6
8. Brading AF. A myogenic basis for the overactive bladder. Urology 1997; 50: 57-67
9. Drake MJ, Mills IW, Gillespie JI. Model of peripheral autonomous modules and a myovesical plexus in normal and overactive bladder function. Lancet 2001; 358: 401-3
10. Sui GP, Rothery S, Dupont E, Fry CH, Severs NJ. Gap junctions and connexin expression in human suburothelial interstitial cells. BJU Int 2002; 90: 118-29
11. Hedreen JC, Bacon SJ, Price DL. A modified histochemical technique to visualize acetylcholinesterase-containing axons. J Histochem Cytochem 1985; 33: 134-40
12. Skalli O, Schurch W, Seemayer T et al. Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins. Laboratory Invest 1989; 60: 275-85
13. Street CH, Mize RR. A simple microcomputer-based three-dimensional serial section reconstruction system (MICROS). J Neurosci Meth 1983; 7: 359-75
14. Moss VA, Jenkinson DM, Elder HY. Automated image segmentation and serial section reconstruction in microscopy. J Microsc 1990; 158: 187-96
15. Wellner M-C, Isenberg G. Properties of stretch-activated channels in myocytes from the guinea-pig urinary bladder. J Physiol (Lond) 1993; 466: 213-27
16. McCloskey KD, Gurney AM. ckit-positive cells in the guinea pig bladder. J Urol 2002; 168: 832-6
17. Smet PJ, Jonavicius J, Marshall VR, de Vente J. Distribution of nitric oxide synthase-immunoreactive nerves and identification of the cellular targets of nitric oxide in guinea-pig and human urinary bladder by cGMP immunohistochemistry. Neuroscience 1996; 71: 337-48
18. Drake MJ, Hussain IF, Hedlund P, Brading AF, Fowler C, Andersson K-E. Characterisation of intramuscular myofibroblasts in human detrusor. BJU Int 2000; 86: 367-8
19. Deverell MH, Bailey N, Whimster WF. Tissue distortion in three-dimensional reconstruction of wax or plastic embedded microscopic structures. Pathol Res Pract 1989; 185: 598-601