Focal changes in nerve, muscle and connective tissue in normal and unstable human bladder

BJU International

Volumn 84, Issue 9, 1999, Pages 953-960

  Charlton, R G ^b   Morley, A R ^b   Chambers, P ^a   Gillespie, J I ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b Newcastle University ^*

Author keywords

Connective tissue; Human bladder; Muscle size; Nerve density

Indexed keywords

COLLAGEN; ELASTIN;

ARTICLE; BLADDER; BLADDER INSTABILITY; BLADDER MUSCLE; CELL LOSS; CELL SIZE; CLINICAL ARTICLE; CONNECTIVE TISSUE; CONTROLLED STUDY; DETRUSOR MUSCLE; HISTOCHEMISTRY; HUMAN; HUMAN TISSUE; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; MUSCLE CELL; NERVE; NERVE CELL; NEUROGENIC BLADDER; PRIORITY JOURNAL;

CONNECTIVE TISSUE DISEASES; HUMANS; HYPERTROPHY; MUSCLE, SMOOTH; MUSCULAR DISEASES; URINARY BLADDER; URINARY BLADDER DISEASES;

EID: 0011581831     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-410X.1999.00360.x     Document Type: Article

References (26)

1. 1 Turner-Warwick RT. Observations on the function and dysfunction of the sphincter and detrusor mechanisms. Urol Clin N Am 1979; 6: 13-30
2. 2 Elbadawi A. Pathology and pathophysiology of detrusor in incontinence. Urol Clin N Am 1995; 22: 499-512
3. 3 German K, Bedwani J, Davies J, Brading AF, Stephenson TP. Physiological and morphometric studies into the pathophysiology of detrusor hyperreflexia in neuropathic patients. J Urol 1995; 153: 1678-83
4. 4 Sehn JT. The ultrastructural effect of distension on the neuromuscular apparatus of the urinary bladder. Invest Urol 1979; 16: 369-75
5. 5 Chapple CR, Smith D. The pathophysiological changes in the bladder obstructed by benign prostatic hyperplasia. Br J Urol 1994; 73: 117-23
6. 6 Cortivo R, Pagano F, Passerini G, Abatangelo G, Castellani I. Elastin and collagen in the normal and obstructed urinary bladder. Br J Urol 1981; 53: 134-7
7. 7 Chacko S, di Santo M, Wang Z, Zederic SS, Wein AJ. Contractile protein changes in Urinary Bladder smooth muscle during obstruction induced hypertrophy. Scan J Urol Neph 1997; Suppl 184: 67-76
8. 8 Uvelius B, Amer A. Changed metabolism of detrusor muscle cells from obstructed rat urinary bladder. Scan J Urol Neph 1997; Suppl 184: 59-66
9. 9 Gosling JA, Gilpin SA, Dixon JS, Gilpin CJ. Decrease in the autonomic innervation of human detrusor muscle in outflow obstruction. J Urol 1986; 136: 501-4
10. 10 Harrison SCW, Hunnam GR, Farman P, Ferguson DR, Doyle PT. Bladder instability and denervation in patients with bladder outflow obstruction. Br J Urol 1987; 6: 519-22
11. 11 Dasgupta P, Chandiramani VA. Beekett A, Fowler CJ, Crowe R, Shah PJR. Flexible cystoscopic biopsies for evaluation of nerve densities in the suburothelium of the human urinary bladder. Br J Urol 1997; 80: 490-2
12. 12 Cumming JA, Chisholm GD. Changes in detrusor innervation with relief of outflow tract obstruction. Br J Urol 1992; 69: 7-11
13. 13 Chapple CR, Milner P, Moss HE, Burnstock G. Loss of sensory neuropeptides in the obstructed human bladder. Br J Urol 1992; 70: 373-81
14. 14 Kim KM, Kogan BA, Massad CA, Huang YC. Collagen and clastin in the obstructed fetal bladder. J Urol 1991; 146: 528-31
15. 15 Moore KH, Gilpin SA, Dixon JS, Richmond DH, Sutherst JR. Increase in presumptive sensory nerves of the urinary bladder in idiopathic detrusor instability. Br J Urol 1992; 70: 370-2
16. 16 Brading AF. A myogenic basis for the overactive bladder. Urology 1997; 50: 57-67
17. 17 Charlton RG, Morley AR, Neal DE, Gillespie JI. Regional variations in nerve density in the bladder wall of patients with idiopathic and neuropathic instability: identification of three discrete areas. J Physiol 1998; 507P: 75P
18. 18 Charlton RG, Morley AR, Maskrey P, Neal DE, Gillespie JI. Focal changes in nerve, muscle and connective tissue density in human idiopathic bladder. J Physiol 1998; 505P: 90P
19. 19 Gilpin SA, Gilpin CJ, Dixon JS, Gosling JA, Kirby RS. The effect of age on the autonomic innervation of the urinary bladder. Br J Urol 1986; 58: 378-81
20. 20 Lowe EM, Anand P, Terenghi G, Williams-Chestnut G, RE, Sinicropi DV. Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and internal cystitis. Br J Urol 1997; 79: 572-7
21. 21 Palea S, Artibani W, Ostardo E, Trist DG, Pietra C. Evidence for purinergic neurotransmission in human urinary bladder affected by internal cystitis. J Urol 1993; 150: 2007-12
22. 22 Steers WD, Kolbecks S, Creedon D, Tuttle JB. Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function. J Clin Invest 1991; 88: 1709-15
23. 23 Milner P, Crowe P, Fernyhough P, Diemel LT, Tomlinson DR, Burnstock G. Nerve growth factor treatment of adult rats selectively enhances innervation of urogenital tract rather than vascular smooth muscl. Int J Dev Neuroscience 1994; 13: 393-401
24. 24 Steers WD, Albo M, Tuttle JB. Calcium channel antagonists prevent urinary bladder growth and neuroplasticity following mechanical stress. Am J Physiol 1994; 266: R20-6
25. 25 Persson K, Sando JJ, Tuttle JB, Steers WD. Protein kinase C in cyclic stretch-induced nerve growth factor production by urinary tract smooth muscle cells. Am J Physiol 1995; 269: C1081-24
26. 26 Persson K, Steers WD, Tuttle JB. Regulation of nerve growth factor secretion in smooth muscle cells cultured from rat bladder body, base and urethra. J Urol 1997; 157: 2000-6