Absorption and systemic availability of two synthetic growth hormone secretogogues and transport of glucose by the proximal small intestine of anestrus dogs after administering estradiol

Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology

Volumn 173, Issue 1, 2003, Pages 61-67

  Nielsen, K K ^a   Buddington, K K ^b   Raun, K ^a   Hansen, T K ^a   Buddington, R K ^b,c  

^a NOVO NORDISK A S   (Denmark)

^b MISSISSIPPI STATE UNIVERSITY   (United States)

^c MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

Carrier mediated; Modulation; PEPT1; SGLT1; Transport

Indexed keywords

EID: 0037872248     PISSN: 01741578     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00360-002-0312-x     Document Type: Article

References (39)

1. Arjmandi BH, Salih MA, Herbert DC, Sims SH, Kalu DN (1993) Evidence for estrogen receptor-linked calcium transport in the intestine. Bone Miner 21:63-74
2. Beierle I, Meibohm B, Derendorf H (1999) Gender differences in pharmacokinetics and pharmacodynamics. Int J Clin Pharmacol 37:529-547
3. Bolscher Netelenbos JC, Barto R, VanBuuren LM, Van der Vijgh WJ (1999) Estrogen regulation of intestinal calcium absorption in the intact and ovariectomized adult rat. J Bone Miner Res 14:1197-1202
4. Breskvar K (1986) The properties of cytochrome P-450 induced in the rat small intestine by estradiol. Steroids 48:85-92
5. Buddington RK, Buddington KK, Sunvold GD (1999) Influence of fermentable fiber on small intestinal dimensions and transport of glucose and proline in dogs. Am J Vet Res 60:354-358
6. Chen C, Noland KA, Kalu DN (1997) Modulation of intestinal vitamin D receptor by ovariectomy, estrogen and growth hormone. Mech Ageing Dev 99:109-122
7. Chen TS, Doong ML, Chang FY, Lee SD, Wang PS (1995) Effects of sex steroid hormones on gastric emptying and gastrointestinal transit in rats. Am J Physiol 268:G171-G176
8. Cohen DI, Illowsky B, Linder MC (1979) Altered copper absorption in tumor-bearing and estrogen-treated rats. Am J Physiol 236:E309-E315
9. Colin EM, Van Den Bemd GJ, Van Aken M, Christakos S, De Jonge HR, Deluca HF, Prahl JM, Birkenhager JC, Buurman CJ, Pols HA, Van Leeuwen JP (1999) Evidence for involvement of 17 beta-estradiol in intestinal calcium absorption independent of 1,25-dihydroxyvitamin D3 level in the rat. J Bone Miner Res 14:57-64
10. Dahiya T, Brasitus TA (1987) Estrogen-induced alterations of hematoside of rat small intestine mucosa. Biochim Biophys Acta 918:230-235
11. + exchange by ethinyl estradiol in rat colonic brush-border membrane vesicles. Biochim Biophys Acta 899:222-228
12. Ferraris RP, Buddington RK, David ES (2000) Ontogeny of nutrient transporters. In: Sanderson IR, Walker WA (eds) Development of the gastrointestinal tract. BC Decker, Saint Louis, pp 123-146
13. Hansen TK, Ankersen M, Hansen BS, Raun K, Nielsen KK, Lau J, Peschke B, Lundt BF, Thøgersen H, Johansen NL, Madsen K, Andersen PH (1998) Novel orally active growth hormone secretagogues. J Med Chem 41:3705-3714
14. Haouari M, Haouari-Oukerro F, Alguemi C, Nagati K, Zouaghi H, Kamoun A (1994) Effects of oestradiol-17 beta on small intestine iron absorption and iron uptake into blood and liver. Horm Metab Res 26:53-54
15. Harris RZ, Benet LZ, Schwartz JB (1995) Gender effects in pharmacokinetics and pharmacodynamics. Drugs 50:222-239
16. Kashuba AD, Nafziger AN (1998) Physiological changes during the menstrual cycle and their effects on the pharmacokinetics and pharmacodynamics of drugs. Clin Pharmacokinet 34:203-218
17. Knodell RG, Allen RC, Kyner WT (1982) Effects of ethinyl estradiol on pharmacokinetics of meperidine and pentobarbital in the rat. J Pharmacol Exp Ther 221:1-6
18. Lee VH (2000) Membrane transporters. Eur J Pharm Sci 11:S41-S50
19. McBurney MI, Massimino SP, Field CJ, Sunvold GD, Hayek MG (1998) Modulation of intestinal function and glucose homeostasis in dogs by the ingestion of fermentable dietary fibers. In: Reinhart GA, Carey DP (eds) Recent advances in canine and feline nutrition. Vol II. Orange Frazier, Wilmington, pp 113-122
20. Molina AS, Paladini A, Gimenez MS (1997) Hormonal influence on lipid-protein interactions in biological membranes. Lactation effects on alkaline phosphatase activity and intestinal brush border membrane properties in rat. Horm Metab Res 29:159-163
21. Oh D-M, Han H-K, Amidon GL (1999) Drug transport and targeting. In: Amidon GL, Sadée W (eds) Membrane transporters as drug targets. Kluwer/Plenum, New York, pp 59-88
22. O'Loughlin PD, Morris HA (1998) Oestrogen deficiency impairs intestinal calcium absorption in the rat. J Physiol (Lond) 511:313-322
23. Polk DB, Barnard JA (1999) Hormones and growth factors in intestinal development. In: Sanderson IR, Walker WA (eds) Development of the gastrointestinal tract. BC Decker, Saint Louis, pp 37-55
24. Poschet JF, Hammond SM, Fairclough PD (1999) Characterization of penicillin G uptake in human small intestinal brush border membrane vesicles. Gut 44:620-624
25. Qin W, Klandorf H (1993) Effect of estrogen in relation to dietary vitamin D3 and calcium on activity of intestinal alkaline phosphatase and Ca-ATPase in immature chicks. Gen Comp Endocrinol 90:318-327
26. Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH (1998) Ipamoreline, the first selective growth hormone secretagogue. Eur J Endocrinol 139:552-561
27. Sabnis S (1999) Factors influencing the bioavailability of peroral formulations of drugs for dogs. Vet Res Comm 23:425-447
28. Salih MA, Sims SH, Kalu DN (1996) Putative intestinal estrogen receptor: evidence for regional differences. Mol Cell Endocrinol 121:47-55
29. +-ATPase activity. Am J Physiol 254:G687-G694
30. Schwarz SM, Watkins JB, Ling SC, Fayer JC, Mone M (1986) Effects of ethinyl estradiol on intestinal membrane structure and functions in the rabbit. Biochim Biophys Acta 860:411-419
31. Sehested A, Hansen B, Raun K, Kramer Nielsen K, Bygballe Johansen P, Kruse Hansen T, Peschke B, Lau J, Høngaard Andersen P, Ankersen M (1999) Pharmacological characterisation of a new oral GH secretagogue, NN703. Eur J Endocrinol 141:180-189
32. Singh P, Townsend CM Jr, Thompson JC (1986) Presence of estradiol-binding proteins in gastrointestinal tract of male rats. Endocrinology 119:1648-1653
33. Singh R, Nagapaul JP, Majumdar S, Chakravarti RN, Dhall GI (1985) Effects of 17 beta-estradiol and progesterone on intestinal digestive and absorptive functions in ovariectomized rats. Biochem Int. 10:777-786
34. Thomas ML, Xu X, Norfleet AM, Watson CS (1993) The presence of functional estrogen receptors in intestinal epithelial cells. Endocrinology 132:426-430
35. Thurmann PA, Hompesch BC (1998) Influence of gender on the pharmacokinetics and pharmacodynamics of drugs. Int J Clin Pharmacol 36:586-590
36. Tsuji A, Tamai I (1996) Carrier-mediated intestinal transport of drugs. Pharm Res 13:963-977
37. Walsh JH (1994) Gastrointestinal hormones and peptides. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven, New York, pp 59-144
38. Weilenmann R, Arnold S, Dobeli M, Rusch P, Zerobin K (1993) Estradiol and progesterone concentrations in the plasma of nonpregnant bitches during the sexual cycle. Schweiz Arch Tierheilkd 135:51-57
39. Zhang L, Brett CM, Giacomini KM (1998) Role of organic cation transporters in drug absorption and elimination. Annu Rev Pharmacol Toxicol 38:431-460