Expression of cAMP-responsive element modulator (CREM) in rat testes following chronic cocaine administration

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 22, Issue 2, 2003, Pages 111-116

  Li, Haikun ^a,b   Dunbar, Joseph C ^a   Dhabuwala, C B ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

CAMP responsive element modulator (CREM); Cocaine; Spermatid; Spermatogenesis; Testes

Indexed keywords

ANTIBODY; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR; NUCLEAR FACTOR; RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASE PAIRING; COCAINE DEPENDENCE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; REPRODUCTIVE TOXICITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPERMATOGENESIS; TESTIS; TESTIS INJURY; TISSUE LEVEL; WESTERN BLOTTING;

ANIMALS; COCAINE; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT MODULATOR; DNA-BINDING PROTEINS; DOPAMINE UPTAKE INHIBITORS; GENE EXPRESSION REGULATION; INJECTIONS, SUBCUTANEOUS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPERMATOGENESIS; TESTIS;

ANIMALIA;

EID: 0037872242     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: 10.1615/JEnvPathToxOncol.v22.i2.40     Document Type: Article

References (21)

1. George VK, Li HK, Teloken C, Grignon DJ, Dwayne LW, Dhabuwala CB. Effects of longterm cocaine exposure on spermatogenesis and fertility in peripubertal male rats. J Urol 1996; 155: 327-331.
2. National Institute of Drug Abuse. What is the scope of cocaine use in the United States? 1999.
3. National Institute of Drug Abuse. National house-hold survey on drug abuse: population estimates. 1997.
4. Li HK, Jiang Y, Rajpurkar A, Dunbar JC, Dhabuwala CB. Cocaine-induced apoptosis in rat testes. J Urol 1999; 162:213-216.
5. Sassone-Corsi P. Transcription factors responsive to cAMP. Annu Rev Cell Dev Biol 1995; 11: 355-377.
6. Foulkes NS, Mellstrom B, Benusiglio E, Sassone-Corsi P. Developmental switch of CREM function during spermatogenesis. Nature 1992; 355: 80-84.
7. Behr R, Weinbauer GF. cAMP-response element modulator (CREM): an essential factor for spermatogenesis in primates? Int J Androl 2001; 24: 126-135.
8. Blendy J, Kastner K, Weinbauer G, Nieschlag F, Schutz G. Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature 1996; 380: 163-165.
9. Nantel F, Monaco L, Foulkes NS, Masquilier D, LeMeur M, Henriksen K, Dierich A, Parvinen M, Sassone-Corsi P. Spermatogenesis deficiency and germ cell apoptosis in CREM-mutant mice. Nature 1996; 380:159-162.
10. Sassone-Corsi P. CREM: a master switch regulating the balance between differentiation and apoptosis in male germ cells. Mol Reprod Develop 2000; 56:228-229.
11. Delmas V, van der Hoorn FF, Mellstrom B. Induction of CREM activators proteins in spermatids: down-stream targets and implications for haploid germ cell differentiation. Mol Endocrinol 1993; 7: 1502-1514.
12. Peri A, Serio M. The CREM system in human spermatogenesis. J Endocrinol Invest 2000; 23: 578-583.
13. De Cesare D, Fimia GM, Sassone-Corsi P. Signaling routes to CREM and CREB: plasticity in transcriptional activation. Trends Biochem 1999; 24:281-285.
14. De Cesare D, Sassone-Corsi P. Transcriptional regulation by cyclic AMP responsive factors. Prog Nucl Acid Res Mol Biol 2000; 64:343-369.
15. Johnson PA, Peschon JJ, Yelick PC, Palmiter RD, Hecht NB. Sequence homologies in the mouse protamin 1 and 2 genes. Biochim Biophys Acta 1988; 950:45-53.
16. Kistler MK, Sassone-Corsi P, Kistler WS. Identification of a functional cyclic adenosine 3′5′-monophosphate response element in the 5′-flanking region of the gene for transition protein 1 (TP1), a basic chromosomal protein of mammalian spermatids. Biol Reprod 1994; 51:1322-1329.
17. Hurst S, Howes EA, Coadwell J, Jones R. Expression of a testes-specific putative actin-capping protein associated with the developing acrosome during rat spermiogenesis. Mol Reprod Develop 1998; 49:81-91.
18. Zhou Y, Sun Z, Means AR, Bernstein KE. cAMP-response element modulator tau is a positive regulator of testes angiotensin converting enzyme transcription. Proc Natl Acad Sci USA 1996; 93: 12262-12266.
19. Fimia GM, De Cesare D, Sassone-Corsi P. CBP-independent activation of CREM and CREB by the LIM-only protein ACT. Nature 1999; 398: 165-169.
20. Weinbauer GF, Behr R, Bergmann M, Nieschlag E. Testicular cAMP responsive element modulator (CREM) protein is expressed in round spermatids but is absent or reduced in men with round spermatid maturation arrest. Mol Human Reprod 1998; 4:9-15.
21. Steger K, Klonisch T, Gavenis K, Behr R, Schaller V, Drabent B, Doenecke D, Nieschlag E, Bergmann M, Weinbauer GF. Round spermatids show normal testes-specific H1t but reduced cAMP responsive element modulator and transition protein 1 expression in men with round spermatid maturation arrest 1999; J Androl 20:747-754.