Synthesis and structure-antifungal activity relationships of 3-aryl-5-alkyl-2,5-dihydrofuran-2-ones and their carbanalogues: Further refinement of tentative pharmacophore group

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 13, 2003, Pages 2843-2866

  Pour, Milan ^a   Špulák, Marcel ^a   Balšánek, Vojtěch ^a   Kuneš, Jiří ^a   Kubanová, Petra ^a   Buchta, Vladimír ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

(PHENYL)CYCLOPENT 2 ENONE; 2,5 DIHYDROFURAN 2 ONE; 3 (2 CHLOROPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 (2,4 DICHLOROPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 (3 BROMOPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 (3 CHLOROPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 (3 FLUOROPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 (3 METHOXYPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 (3 TRIFLUOROMETHYLPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 (3,4 DIBROMOPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 (3,4 DICHLOROPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 (3,4 DIFLUOROPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 (4 BROMOPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 (4 CHLOROPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 (4 FLUOROPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 (4 METHOXYPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 (4 METHYLPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 (4 NITROPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 (4 TRIFLUOROMETHYLPHENYL) 5 METHYL 2,5 DIHYDROFURAN 2 ONE; 3 PHENYL 5 METHYL 2,5 DIHYDROFURAN 2 ONE; ALKYL GROUP; AMPHOTERICIN B; CYCLOPENTENONE DERIVATIVE; FURANONE DERIVATIVE; HALOGEN; INCRUSTOPORINE; KETOCONAZOLE; NATURAL PRODUCT; PHENYL GROUP; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ABSIDIA; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; FUNGAL STRAIN; IN VITRO STUDY; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ABSIDIA CORYMBIFERA; ASPERGILLUS FUMIGATUS;

EID: 0037871836     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00220-7     Document Type: Article

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