Molecular strategies and 111in-labelled somatostatin analogues in defining the management of neuroendocrine tumour disease: A new paradigm for surgical management

Surgeon

Volumn 1, Issue 3, 2003, Pages 137-143

  Modlin, I M ^a   Kidd, M ^a   Hinoue, T ^a   Lye, K D ^a   Murren, J ^a   Argiris, A ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

ECL cell; Gene chip; Mastomys; Neuroendocrine; Somatostatin; Surgery; Tumour

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; CHROMOGRANIN A; CYCLIN D1; GASTRIN; INDIUM 111; METHIONINE; ONCOPROTEIN; PENTETREOTIDE IN 111; POLYPEPTIDE; SEROTONIN; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR; TRANSCRIPTION FACTOR AP 1; VASOACTIVE INTESTINAL POLYPEPTIDE; DIAGNOSTIC AGENT; INDIUM; SOMATOSTATIN; SOMATOSTATIN RECEPTOR 2;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW SUPPRESSION; CELL CYCLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE MARKER; DISEASE MODEL; DRUG EFFICACY; ENDOCRINE SURGERY; ENTEROCHROMAFFIN CELL; GENE MUTATION; GENE TARGETING; GENETIC ANALYSIS; GENETIC IDENTIFICATION; GROWTH INHIBITION; HETEROZYGOSITY LOSS; HORMONE DETERMINATION; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY FAILURE; KIDNEY TUBULE NECROSIS; MOLECULAR MECHANICS; NEUROENDOCRINE TUMOR; NEUROSURGERY; NONHUMAN; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; TUMOR CELL; ANIMAL; DNA MICROARRAY; DRUG DELIVERY SYSTEM; GENE EXPRESSION PROFILING; GENETIC DATABASE; GENETICS; MURIDAE; PHYSIOLOGY; SCINTISCANNING;

ANIMALS; CELL CYCLE; CELL PROLIFERATION; DATABASES, GENETIC; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; ENTEROCHROMAFFIN CELLS; GENE EXPRESSION PROFILING; HUMANS; INDIUM RADIOISOTOPES; MURIDAE; NEUROENDOCRINE TUMORS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN;

EID: 0037870384     PISSN: 1479666X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1479-666X(03)80092-6     Document Type: Article

References (32)

1. Modlin I, Sandor A, Tang L, Kidd M, Zelterman D. A 40-year analysis of 265 gastric carcinoids. Am J Gastroenterol 1997; 92:633-638.
2. Modlin I, Tang L. The Gastric Enterochromaffin-like Cell: An Enigmatic Cellular Lesion. Gastroenterol 1996; 111:783-810.
3. Rindi G, Bordi C, Rappel S, La Rosa S, Stolte M, Solcia E. Gastric carcinoids and neuroendocrine carcinomas: pathogenesis, pathology and behavior. World J Surg 1996; 20:168-172.
4. Modlin IM, Nangia AK. The pathobiology of the human enterochromaffin-like cell. Yale J Biol and Med 1992; 65:775-792.
5. Modlin I, Zucker K, Zdon M, Sussman J, Adrian T. Characteristics of the spontaneous gastric endocrine tumor of Mastomys. J Surg Res 1988; 44: 205-215.
6. Nilsson O, Wangberg B, Johansson L, Theodorsson E, Dahlstrom A, Modlin IM, Ahlman H. Rapid induction of enterochromaffin-like cell tumors by histamine 2 receptor blockade. Am J Pathol 1993; 142:1173-1185.
7. Modlin IM, Lawton GP, Tang LH, Geibel J, Abraham R, Darr U. The Mastomys gastric carcinoid: Aspects of ECL cell function. Digestion 1994; 55 (Suppl 3):31-37.
8. Modlin I, Cornelius E, Lawton G. Use of an isotopic somatostatin receptor probe to image gut endocrine tumors. Arch Surg 1995; 130:367-373.
9. Modlin I, Murren J, Cornelius E, Kidd M, Lye KD, Hinoue T. The utility of octreotide and isotopes in the diagnosis and treatment of neuroendocrine tumors (NETs). Journal of Gastroenterology and Hepatology 2002; 17(Suppl): A80.
10. Afargan M, Janson ET, Gelerman G, Rosenfeld R, Ziv O, Karpov O, Wolf A, Bracha M, Shohat D, Liapakis G, Gilon G, Hoffman A, Stephensky D, Öberg K. Novel long-acting somatostatin analog with endocrine selectivity: Potent suppression of growth hormone but not of insulin. Endocrinology 2001; 142(1):477-486.
11. Modlin I, Zucker K, Zdon M, Sussman J, Adrian T. Characteristics of the spontaneous gastric endocrine tumor of Mastomys. J Surg Res 1988; 44: 205-215.
12. Nilsson O, Wangberg B, Johansson L, Theodorsson E, Dahlstrom A, Modlin IM, Ahlman H. Rapid induction of enterochromaffin-like cell tumors by histamine 2 receptor blockade. Am J Pathol 1993; 142:1173-1185.
13. Modlin IM, Lawton GP, Tang LH, Geibel J, Abraham R, Darr U. The Mastomys gastric carcinoid: Aspects of ECL cell function. Digestion 1994; 55 (Suppl 3):31-37.
14. Tang L, Luque E, Efstathiou J, Bortecen KH, Kidd M, Tarasova N, Modlin I. Gastrin receptor expression and function during rapid transformation of the enterochromaffin-like cells in an African rodent. Regul Pept 1997; 72:9-18.
15. Lauffer J, Tang L, Zhang T, Hinoue T, Rahbar S, Odo M, Modlin I, Kidd M. PACAP mediates the neural proliferative pathway of Mastomys Enterochromaffin-like cell transformation. Regul Pept 2001; 102:157-164.
16. Tang L, Modlin I, Lawton G, Kidd M, Chinnery R. The Role of TGF-alpha in the Enterochromaffin-like (ECL) Cell Tumor Autonomy in an African Rodent Mastomys. Gastroenterol 1996; 111:1212-1223.
17. Modlin IM, Kumar R, Soroka CJ, Pasikhov D, Nangia A, Goldenring JR. Gastrin-dependent inhibitory effects of octreotide on the genesis of Gastric ECLomas. Surgery. 1992; 112:1048-1056.
18. Reubi JC, Waser B, Horisberger U, Halter F, Soroka CJ, Kumar RR, Goldenring JR, Modlin IM. Identification of somatostatin and gastrin receptors on enterochromaffin-like cells from Mastomys gastric tumors. Endocrinol 1992; 131:166-172.
19. Borin J, Tang L, Kidd M, Miu K, Bortecen K, Sandor A, Modlin I. Somatostatin receptor (SSTR) regulation of gastric Enterochromaffin-like cell transformation to gastric carcinoid. Surgery 1996; 120: 1026-1032.
20. Okabe H, Satoh H, Kato T, Kitara O, Yanagawa, R, Yamaoka Y, Tsunoda T, Furukawa Y, Nakamura Y. Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA micro-array: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res 2001; 61:2129-2137.
21. Kidd M, Wen Y, Asatryan L, Prinz C, Modlin I, Sachs G. Global gene expression analysis of enriched rat fundic neuroendocrine cell populations. Gastroenterol 2002; 122:W876.
22. Calender A. Molecular genetics of neuroendocrine tumors. Digestion 2000; 62(Suppl 1):3-18.
23. Debelenko L, Emmert-Buck M, Zhuang Z, Epshteyn E, Moskaluk C, Jensen R, Liotta L, Lubensky I. The multiple endocrine cell neoplasia type I gene locus is involved in the pathogenesis of type II gastric carcinoids. Gastroenterol 1997; 113:773-781.
24. D'Adda T, Keller G, Bordi C, Hofler H. Loss of heterozygosity in 11q-13-14 regions in gastric neuroendocrine tumors not associated with multiple endocrine neoplasia type 1 syndrome. Lab Invest 1999; 79:671-677.
25. Chung D, Brown S, Graeme-Cook F, Seto M, Warshaw A, Jensen R, Arnold A. Over expression of cyclin D1 occurs frequently in human pancreatic endocrine tumors. J. Clin Endocrinol Metab 2000; 85:4373-4378.
26. Serrano J, Goebel S, Peghini P, Lubensky I, Gibril F, Jensen R. Alterations in the p16INK4a/CDKN2A tumor suppressor gene in gastrinomas. J Clin Endocrinol Metab 2000; 85:4146-4156.
27. Wang D, Johnston C, Buchanan K. Oncogene expression in gastroenteropancreatic neuroendocrine tumors. Cancer 1997; 88: 668-675.
28. Zhang T, Tang L, Kidd M, Lauffer J, Modlin I. Gastric enterochromaffin-like (ECL) transformation is associated with increased expression of the G1 cell cycle regulators cyclin D1 and cdk4. Gastroenterol 1998; 114:G2932.
29. Zhang T, Tang L, Lauffer J, Svennevik E, Modlin I. Unregulated cyclin D1 expression plays an important role in the proliferation of enterochromaffin-like (ECL) cells in the Mastomys. Gastroenterol 1999; 116:G2353.
30. Fahardi J, Hinoue T, Lauffer J, Tang L, Wang J, Modlin I. The transcriptional regulation of c-fos/c-jun during PACAP stimulated ECL cell proliferation. Gastroenterol 2000; 118:623.
31. Kidd M, Mignon M-O, Macy J, Hinoue T, Lye K, Modlin I. Menin and the molecular pathogenesis of neuroendocrine tumors in the Mastomys model. J Gastroenterol Hepatol 2002; 17 (Suppl):A407.
32. Smith A, Watson S, Caplin M, Clarke P, Griffin N, Varro A, Hardcastle J. Gastric carcinoid expresses the gastrin autocrine pathway. Br J Surg 1998; 85: 1285-1289.