A unique variant of ETV6/AML1 fusion in a child with acute lymphoblastic leukemia [9]

Leukemia

Volumn 17, Issue 5, 2003, Pages 993-995

  Jalali, G R ^a   Martineau, M ^a   Ford, A M ^b   Greaves, M ^b   Stevens, R F ^c   Harrison, C J ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c ROYAL MANCHESTER CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

ACUTE LYMPHOCYTIC LEUKEMIA; AMPLICON; BLAST CELL; CASE REPORT; CHILDHOOD LEUKEMIA; CHROMOSOME 1; CHROMOSOME 10; CHROMOSOME 12; CHROMOSOME 13; CHROMOSOME 21; CHROMOSOME ANALYSIS; CHROMOSOME TRANSLOCATION; CLINICAL FEATURE; CYTOGENETICS; EXON; FLUORESCENCE IN SITU HYBRIDIZATION; GENE INSERTION; HEPATOMEGALY; HUMAN; INTRON; KARYOTYPING; LETTER; MALE; METAPHASE; PRESCHOOL CHILD; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0037851049     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402873     Document Type: Letter

References (7)

1. Shurtleff SA, Buijs A, Behm FG, Rubnitz JE, Raimondi SC, Hancock ML et al. TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia 1995; 9: 1985-1989.
2. Borkhardt A, Cazzaniga G, Viehmann S, Valsecchi MG, Ludwig WD, Burci L et al. Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Munster Study Group. Blood 1997; 90: 571-577.
3. Romana SP, Le Coniat M, Berger R. t(12;21): a new recurrent translocation in acute lymphoblastic leukemia. Genes Chromosome Cancer 1994; 9: 186-191.
4. Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P et al. Fusion of the TEL gene on 12p13 to the AML1 gene on 21 q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA 1995; 92: 4917-4921.
5. Mathew S, Shurtleff SA, Raimondi SC. Novel cryptic, complex rearrangements involving ETV6-CBFA2 (TEL-AML1) genes identified by fluorescence in situ hybridization in pediatric patients with acute lymphoblastic leukemia. Genes Chromosome Cancer 2001; 32: 188-193.
6. Reddy KS, Yang X, Mak L, Wang S, Johnston M. A child with ALL and ETV6/AML1 fusion on a chromosome 12 due to an insertion of AML1 and loss of ETV6 from the homolog involved in a t(12;15)(p13;q15). Genes Chromosome Cancer 2000; 29: 106-109.
7. Ford AM, Bennett CA, Price CM, Bruin MC, van Wering ER, Greaves M. Fetal origins of the TEL-AML1 fusion gene in iden-tical twins with leukemia. Proc Natl Acad Sci USA 1998; 95: 4584-4588.