Focal CO2/H+ alters phrenic motor output response to chemical stimulation of cat pre-Bötzinger complex in vivo

Journal of Applied Physiology

Volumn 94, Issue 6, 2003, Pages 2151-2157

  Solomon, Irene C ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Central CO2 H+ chemosensitivity; Neural control of breathing; Respiratory rhythm generation

Indexed keywords

ACETAZOLAMIDE; CARBON DIOXIDE; CARBONATE DEHYDRATASE; CHLORALOSE; HOMOCYSTEIC ACID; METHAZOLAMIDE; PROTON; DRUG DERIVATIVE; HOMOCYSTEINE;

ACIDOSIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN STEM; CAT; CHEMOSENSITIVITY; EXCITATION; HYPERCAPNIA; IN VIVO STUDY; MICROINJECTION; MOTOR ACTIVITY; NONHUMAN; PHRENIC NERVE; PRE BOTZINGER COMPLEX; PRIORITY JOURNAL; RESPIRATION CONTROL; RESPIRATORY BURST; ANIMAL; DRUG EFFECT; MEDULLA OBLONGATA; METABOLISM; PATHOPHYSIOLOGY;

ACIDOSIS; ANIMALS; CARBON DIOXIDE; CATS; HOMOCYSTEINE; MEDULLA OBLONGATA; MICROINJECTIONS; MOTOR ACTIVITY; PHRENIC NERVE; PROTONS;

EID: 0037840722     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.01192.2002     Document Type: Article

References (23)

1. Bongianni F, Fontana G, and Pantaleo T. Effects of electrical and chemical stimulation of the Bötzinger complex on respiratory activity in the cat. Brain Res 445: 254-261, 1988.
2. Chitravanshi VC and Sapru HN. Phrenic nerve responses to chemical stimulation of the subregions of ventral medullary respiratory neuronal group in the rat. Brain Res 821: 443-460, 1999.
3. Coates EL, Li A, and Nattie EE. Widespread sites of brain stem ventilatory chemoreceptors. J Appl Physiol 75: 5-14, 1993.
4. Connelly CA, Dobbins EG, and Feldman JL. Pre-Bötzinger complex in cats: respiratory neuronal discharge patterns. Brain Res 590: 337-340, 1992.
5. Gray PA, Janczewski W, Mellen N, McCrimmon DR, and Feldman JL. Normal breathing requires preBötzinger complex neurokinin-1 receptor-expressing neurons. Nat Neurosci 4: 927-930, 2001.
6. Johnson SM, Trouth CO, and Smith JC. Chemosensitivity of respiratory pacemaker neurons in the pre-Bötzinger complex in vitro. Neurosci Abstr 24: 875, 1998.
7. Koshiya N and Smith JC. Neuronal pacemaker for breathing visualized in vitro. Nature 400: 360-363, 1999.
8. 5-substituted 2-acetylamino-1,3,4-thiadiazole-5-sulfonamides: metabolic conversion and use as control substances. J Pharmacol Exp Ther 117: 385-401, 1956.
9. Maren TH. The general physiology of reactions catalyzed by carbonic anhydrase and their inhibition by sulfonamides. Ann NY Acad Sci 429: 246-258, 1984.
10. McCrimmon DR, Feldman JL, and Speck DF. Respiratory motoneuronal activity is altered by injections of picomoles of glutamate into cat brain stem. J Neurosci 6: 2384-2392, 1986.
11. McCrimmon DR, Monnier A, Hayashi F, and Zuperku EJ. Pattern formation and rhythm generation in the ventral respiratory group. Clin Exp Pharmacol Physiol 27: 126-131, 2000.
12. O'Neal MH III, Provitera P, and Solomon IC. Three-dimensional functional representation of functionally identified pre-Bötzinger complex sites in adult cat. Neurosci Abstr 27: program no. 633.6, 2001.
13. Ramirez JM, Schwarzacher SW, Pierrefiche O, Olivera BM, and Richter DW. Selective lesioning of the cat pre-Bötzinger complex in vivo eliminates breathing but not gasping. J Physiol 507: 895-907, 1998.
14. Rekling JC and Feldman JL. PreBötzinger complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation. Annu Rev Physiol 60: 385-405, 1998.
15. Schwarzacher SW, Smith JC, and Richter DW. Pre-Bötzinger complex in the cat. J Neurophysiol 73: 1452-1461, 1995.
16. Smith JC, Butera RJ, Koshiya N, Del Negro C, Wilson CG, and Johnson SM. Respiratory rhythm generation in neonatal and adult mammals: the hybrid pacemaker-network model. Respir Physiol 122: 131-147, 2000.
17. Smith JC, Ellenberger HH, Ballanyi K, Richter DW, and Feldman JL. Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 254: 726-729, 1991.
18. Solomon IC. Modulation of expiratory motor output evoked by chemical activation of pre-Bötzinger complex in vivo. Respir Physiol Neurobiol 130: 235-251, 2002.
19. Solomon IC. Influence of respiratory network drive on phrenic motor output evoked by activation of cat pre-Bötzinger complex in vivo. Am J Physiol Regul Integr Comp Physiol 284: R455-R466, 2003.
20. Solomon IC, Edelman NH, and Neubauer JA. Patterns of phrenic motor output evoked by chemical stimulation of neurons located in the pre-Bötzinger complex in vivo. J Neurophysiol 81: 1150-1161, 1999.
21. + chemoreception in the cat pre-Bötzinger complex in vivo. J Appl Physiol 88: 1996-2007, 2000.
22. Sun QJ, Goodchild AK, Chalmers JP, and Pilowsky PM. The pre-Bötzinger complex and phase-spanning neurons in the adult rat. Brain Res 809: 204-213, 1998.
23. Wang H, Germanson TP, and Guyenet PG. Depressor and tachypneic responses to chemical stimulation of the ventral respiratory group are reduced by ablation of neurokinin-1 receptor-expressing neurons. J Neurosci 22: 3755-3764, 2002.