Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme a reductase and cholesterol 7α-hydroxylase on the pathogenesis of Manganese-bilirubin-induced cholestasis in rats

Toxicological Sciences

Volumn 73, Issue 2, 2003, Pages 378-385

  Akoume, Marie Yvonne ^a,b   Perwaiz, Shahid ^a,b   Yousef, Ibrahim M ^a,b   Plaa, Gabriel L ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Canalicular membranes; Cholate; Cholesterol; Cholesterol 7 hydroxylase; HMG CoA reductase; Phospholipid

Indexed keywords

BILE ACID; BILIRUBIN; CHENODEOXYCHOLIC ACID; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MANGANESE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE FLOW; BILE SECRETION; CELLULAR DISTRIBUTION; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DEGRADATION KINETICS; ENZYME ACTIVITY; ENZYME INHIBITION; INTRAHEPATIC BILE DUCT; INTRAHEPATIC CHOLESTASIS; LIVER MEMBRANE; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; PATHOGENESIS; RAT;

ANIMALS; BILE; BILE ACIDS AND SALTS; BILE CANALICULI; BILIRUBIN; CHOLESTASIS, INTRAHEPATIC; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIVER; MALE; MANGANESE COMPOUNDS; PHOSPHOLIPIDS; RATS; RATS, SPRAGUE-DAWLEY; SULFATES; TIME FACTORS;

ANIMALIA; VERTEBRATA;

EID: 0037834659     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg054     Document Type: Article

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