Associations of blood lead levels, kidney function, and blood pressure with 6-aminolevulinic acid dehydratase and vitamin D receptor gene polymorphisms

Toxicology Mechanisms and Methods

Volumn 13, Issue 2, 2003, Pages 139-146

  Ye, Xi Biao ^a   Wu, Cui E ^a   Fu, Hua ^a   Yang, Shui Lian ^b   Lu, Yi Wen ^b   Ni, Wei Min ^b  

^a FUDAN UNIVERSITY   (China)

^b Tongji University School of Medicine   (China)

Author keywords

Blood Pressure; Lead; Nephrotoxicity; Polymorphism; Vitamin D Receptor; Aminolevulinic Acid Dehydratase

Indexed keywords

ALBUMIN; BIOLOGICAL MARKER; CREATININE; LEAD; N ACETYL BETA GLUCOSAMINIDASE; PORPHOBILINOGEN SYNTHASE; VITAMIN D RECEPTOR;

ADULT; ARTICLE; BATTERY INDUSTRY; BLOOD PRESSURE MEASUREMENT; CONCENTRATION RESPONSE; ENZYME ACTIVITY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; KIDNEY FUNCTION; LEAD BLOOD LEVEL; LEAD POISONING; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; NEPHROTOXICITY; OCCUPATIONAL EXPOSURE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; URINE LEVEL;

EID: 0037833587     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.1080/15376510309840     Document Type: Article

References (30)

1. Astrin, K. H., Bishop, D. F., Wetmur, J. G., Kaul, B. C., Davidow, B., and Desnick, R. J, 1987. Delta-aminolevulinic acid dehydratase isozymes and lead toxicity. Ann. N. Y. Acad. Sci. 514:23-29.
2. Agency for Toxic Substances and Disease Registry. 1997. Toxicological Profile for Lead, 27-35. Atlanta, GA: ATSDR.
3. Bergdahl, I. A., Gerhardsson, L., Schutz, A., Desnich, R. J., Wetmur, J. G., and Skerfving, S. 1997. δ-aminolevulinate acid dehydratase polymorphism: influence on lead levels and kidney function in humans. Arch. Environ. Health 52:91-96.
4. Dawson-Hughes, B., Harris, S. S., Krall, E. A., and Dallal, G. E. 1997. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N. Engl. J. Med. 337:670-676.
5. Gong, G., Stern, H. S., Cheng, S. C., Fong, N., Mordenson, J., Deng, H. W., and Recker, R. R. 1999. The association of bone mineral density with vitamin D receptor gene polymorphisms. Osteoporos. Int. 9:55-64.
6. Gough, A., Sambrook, P., Devlin, J., Huisoon, A., Betteridge, J., Franklyn, J., Nguyen, T., Morrison, N., Eisman, J., and Emery, P. 1998. Effect of vitamin D receptor gene alleles on bone loss in early rheumatoid arthritis. J. Rheumatol. 25:864-868.
7. Howard, G., Nguyen, T., Morrison, N., Watanabe, T., Sambrook, P., Eisman, J., and Kelly, P. J. 1995. Genetic influences on bone density, physiological correlates of vitamin D receptor gene alleles in premenopausal women. J. Clin. Endocrinol. Metab. 80:2800-2805.
8. Jorde, R., and Benaa, K. H. 2000. Calcium from dairy products, vitamin D intake, and blood pressure: the Tromse study. Am. J. Clin. Nutr. 71:1530-1535.
9. Kelada, S. N., Shelton, E., Kaufmann, R. B., and Khoury, M. J. 2002. δ-aminolevulinate acid dehydratase genotype and lead toxicity: A HuGE review. Am. J. Epidemiol. 154:1-13.
10. Kristal-Boneh, E., Froom, P., Yerushalmi, N., Harari, G., and Ribak, J. 1998. Calcitropoic hormones and occupational lead exposure. Am. J. Epidemiol. 147:458-463.
11. Lee, B. K., Lee, G. S., Stewart, W. F., Ahn, K. D., Simon, D., Kelsey, K. T., Todd, A. C., and Schwartz, B. S. 2001. Associations of blood pressure and hypertension with lead dose measures and polymorphisms in the vitamin D receptor and δ-aminolevulinate acid dehydratase genes. Environ. Health Perspect. 109:383-389.
12. Mahmoud, L. A. 1997. Renal effects of environmental and occupational lead exposure. Environ. Health Perspect. 105:928-938.
13. Mason, H. J., Somervaille, J. L., Wright, A. L., Chettle, D. R., and Scott, M. C. 1990. Effect of occupational lead exposure on serum 1,25-dihydroxyvitamin D levels. Hum. Exp. Toxicol. 9:29-34.
14. Miller, G. D., DiRienzo, D. D., Reusser, M. E., and McCarron, D. A. 2000. Benefits of dairy product consumption on blood pressure in humans: a summary of the biomedical literature. J. Am. Coll. Nutr. 19(suppl): 147S-164S.
15. Morrison, N. A., Qi, J. C., Tokita, A., Kelly, P. J., Crofts, L., Nguyen, T. V., Sambrook, P. N., and Eisman, J. A. 1994. Prediction of bone density from vitamin D receptor alleles. Nature 367:284-287.
16. Onalaja, A. O., and Claudio, L. 2000. Genetic Susceptibility to lead poisoning. Environ. Health Perspect. 108 suppl:23-28.
17. Osborne, C. G., McTyre, R. B., Dudek, J., Roche, K. E., Scheuplein, R., Silversgtein, B., Weinberg, M. S., and Salkeld, A. A. 1996. Evidence of the relationship of calcium to blood pressure. Nutr. Rev. 4:365-381.
18. Petrucci, R., Leonardi, A., and Battistuzzi, G. 1982. The genetic polymorphism of δ-aminolevulinate acid dehydratase in Italy. Hum. Genet. 60:289-290.
19. Schwartz, B. S., Lee, B. K., Lee, G. S., Stewart, W. F., Simon, D., Kelsey, K., and Todd, A. C. 2000a. Associations of blood lead, aminolevulinate acid chelatable lead, and tibia lead with polymorphisms in the vitamin D receptor and δ-aminolevulinate acid dehydratase genes. Enivron. Health Perspect. 108:949-954.
20. Schwartz, B. S., Stewart, W. F., and Todd, A. C. 2000b. Different association of blood lead, meso2,3-ddimercaptosuccinic acid (DMSA) - chelatable lead, and tibia lead levels with blood pressure in 543 former organolead manufacturing workers. Arch. Environ. Health 55:85-92.
21. Smith, C. M., Wang, X., Hu, H., and Kelsey, K. 1995. A polymorphism in the δ-aminolevulinate acid dehydratase gene may modify the pharmacokinetics and toxicity of lead. Environ. Health Perspect. 103:248-253.
22. Sowers, M. R., Wallace, R. B., and Lemke, J. H. 1985. The association of intakes of vitamin D and calcium with blood pressure among women. Am. J. Clin. Nutr. 42:135-142.
23. Tokita, A., Matsumoto, H., Morrison, N. A., Tawa, T., Miura, Y., Fukamauchi, K., Mitsuhashi, N., Irimoto, M., Yamamori, S., and Miura, M. 1996. Vitamin D receptor alleles, bone mineral density and turnover in premenopausal Japanese women. J. Bone Miner. Res. 11:1003-1009.
24. Wang, Y. L. 1993. Occupational Health, 3rd ed. Beijing, China: People's Health Publishing House.
25. Wetmur, J. G., Lehnert, G., and Desnick, R. J. 1991a. The δ-aminolevulinate dehydratase polymorphism: higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 2-2 isozymes. Environ. Res. 56:109-119.
26. Wetmur, J. G., Kaya, A. H., Plewinska, M., and Desnick, R. J. 1991b. Molecular characterization of the human δ-aminolevulinate acid dehydratase 2(ALAD2) allele: implications for molecular screening of individuals for genetic susceptibility to lead poisoning. Am. J. Hum. Genet. 49:757-763.
27. Ye, X. B., Ni, W. M., Yang, S. L., and Fu, H. 2001. ALAD gene polymorphism and blood lead level: a meta-analysis. Guandong Weiliang Yuansu Kexue 8:22-26 (in Chinese).
28. Zhen, Y. X., Song, W. J., Wang, Y. W., Min, H. F., Zhou, X. L., Wu, Y. Q., and Huang, Q. X. 2000. Association of ALAD gene polymorphism and lead neurotoxicity. Chin. J. Pub. Health 16:908-910. (in Chinese).
29. Ziemsen, B., Angerer, J., Lehnert, G., Benkmann, H. O., and Goedde, H. W. 1986. Polymorphism of delta-aminolevulinic dehydratase in lead-exoposed workers. Int. Arch. Occup. Environ. Health 58:245-247.
30. Zmuda, J. M., Cauley, J. A., Danielson, M. E., Wolf, R. L., and Ferrell, R. E. 1997. Vitamin D receptor gene polymorphisms, bone turnover, and rates of bone loss in older African-American women. J. Bone Miner. Res. 12:1446-1452.