Bioinformatics: Implications for medical research and clinical practice

Clinical and Investigative Medicine

Volumn 26, Issue 2, 2003, Pages 70-74

  Lynn, David J ^a,b   Lloyd, Andrew T ^a,c   O'Farrelly, Cliona ^a,b  

^a ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOINFORMATICS; CLINICAL RESEARCH; DIAGNOSTIC PROCEDURE; GENE EXPRESSION; GENE IDENTIFICATION; GENOMICS; HUMAN; MEDICAL PRACTICE; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SEQUENCE HOMOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 0037832463     PISSN: 0147958X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (17)

1. Wieczorek SJ, Tsongalis GJ. Pharmacogenomics: Will it change the field of medicine? Clin Chim Acta 2001;308:1-8.
2. Taylor JG, Choi EH, Foster CB, Chanock SJ. Using genetic variation to study human disease. Trends Mol Med 2001;7:507-12.
3. Weinshilboum R. Thiopurine pharmacogenetics: clinical and molecular studies of thiopurine methyltransferase. Drug Metab Dispos 2001;29:601-5.
4. Alves S, Prata MJ, Ferreira F, Amorim A. Thiopurine methyltransferase pharmacogenetics: alternative molecular diagnosis and preliminary data from Northern Portugal. Pharmacogenetics 1999;9:257-61.
5. Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, et al. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 2001;409:928-33.
6. Bennett LM, Brownlee HA, Hagavik S, Wiseman RW. Sequence analysis of the rat Brcal homolog and its promoter region. Mamm Genome 1999;10:19-25.
7. Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, et al. Discovery of five conserved beta-defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A 2002;99:2129-33.
8. Brett D, Kemmner W, Koch G, Roefzaad C, Gross S, Schlag PM. A rapid bioinformatic method identifies novel genes with direct clinical relevance to colon cancer. Oncogene 2001;20:4581-5.
9. Maughan NJ, Lewis FA, Smith V. An introduction to arrays. J Pathol 2001;195:3-6.
10. Hess KR, Zhang W, Baggerly KA, Stivers DN, Coombes KR. Microarrays: handling the deluge of data and extracting reliable information. Trends Biotechnol 2001;19:463-8.
11. Yang YH, Speed T. Design issues for cDNA microarray experiments. Nat Rev Genet 2002;3:579-88.
12. Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001;98:10869-74.
13. Sauter G, Simon R. Predictive molecular pathology. N Engl J Med 2002;347:1995-6.
14. Demirev PA, Lin JS, Pineda FJ, Fenselaut C. Bioinformatics and mass spectrometry for microorganism identification: proteome-wide post-translational modifications and database search algorithms for characterization of intact H. pylori. Anal Chem 2001;73:4566-73.
15. Zhu T, Korber BT, Nahmias AJ, Hooper E, Sharp PM, Ho DD. An African HIV-1 sequence from 1959 and implications for the origin of the epidemic. Nature 1998;391:594-7.
16. Lorenzo E, Collins T, Fisher E, Herrera RJ. The use of tat and env sequences from human immunodeficiency virus 1 in phylogenetic epidemiological studies. Electrophoresis 2001;22:438-44.
17. Watson JD, Crick FH. A structure for deoxyribonucleic acid. Nature 1953;171:737-8.