Needed: Mouse/human cross validation of reinstatement/relapse models (and drug reward models) to model human substance abuse vulnerability allelic variants

Psychopharmacology

Volumn 168, Issue 1-2, 2003, Pages 42-43

  Uhl, George R ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL;

ALLELIC EXCLUSION; ALLELISM; ANIMAL CELL; DRUG ABUSE; DRUG DEPENDENCE; DRUG EFFECT; GENETIC VARIABILITY; HUMAN; HUMAN CELL; LETTER; MOLECULAR GENETICS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REINSTATEMENT MODEL; RELAPSE; REWARD; SUBSTANCE ABUSE; VALIDATION PROCESS;

ALLELES; ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; MICE; MODELS, PSYCHOLOGICAL; RECURRENCE; REPRODUCIBILITY OF RESULTS; REWARD; SUBSTANCE-RELATED DISORDERS; VARIATION (GENETICS);

EID: 0037825763     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-003-1499-6     Document Type: Letter

References (10)

1. Kendler KS, Karkowski LM et al. (1999)Genetic and environmental risk factors in the aetiology of illicit drug initiation and subsequent misuse in women. Br J Psychiatry 175:351-356
2. McBride WJ, Murphy JM, Ikemoto S (1999) Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies. Behav Brain Res 101:129-152
3. Schuckit MA (2001) Correlates of unpredicted outcomes in sons of alcoholics and controls. J Stud Alcohol 62:477-485
4. Shalev U, Grimm JW, Shaham Y (2002) Neurobiology of relapse to heroin and cocaine: a review. Pharmacol Rev 54:1-42
5. Stewart J (2000) Pathways to relapse: the neurobiology of drug-and stress-induced relapse to drug-taking. J Psychiatry Neurosci 25:125-136
6. Tsuang MT, Lyons MJ et al. (1999) Genetic and environmental influences on transitions in drug use. Behav Genet 29:473-479
7. Tzschentke TM (1998) Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues. Prog Neurobiol 56:613-672
8. Uhl GR (1999) Molecular genetics of substance abuse vulnerability: a current approach. Neuropsychopharmacology 20:3-9
9. Uhl GR, Elmer GI et al. (1995) Genetic influences on drug abuse. In: Bloom F, Kupfer DJ (eds) Psychopharmacology: the fourth generation of progress. Raven Press, New York, pp 1793-1806
10. Uhl GR, Liu QR et al. (2002) Substance abuse vulnerability loci: converging genome scanning data. Trends Genet 18:420-425