The effects of body fat on pulmonary function and gas exchange in cynomolgus monkeys

Pulmonary Pharmacology and Therapeutics

Volumn 16, Issue 5, 2003, Pages 313-319

  Young, S S ^a,b   Skeans, S M ^a   Austin, T ^a   Chapman, R W ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Leptin; Non human primate; Obesity; Oxygen flux; Respiratory mechanics

Indexed keywords

LEPTIN;

AMBIENT AIR; ANIMAL EXPERIMENT; ARTERIAL GAS; ARTERIAL OXYGEN TENSION; ARTICLE; ARTIFICIAL VENTILATION; BODY FAT; BREATHING PATTERN; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FUNCTIONAL RESIDUAL CAPACITY; LUNG ALVEOLUS OXYGEN TENSION; LUNG COMPLIANCE; LUNG GAS EXCHANGE; LUNG MECHANICS; LUNG RESISTANCE; LUNG VENTILATION PERFUSION RATIO; MALE; MONKEY; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RADIOIMMUNOASSAY; SPECIES COMPARISON; TIDAL VOLUME;

EID: 0037822209     PISSN: 10945539     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1094-5539(03)00073-7     Document Type: Article

References (19)

1. Bardoczky G.I., Yernault J.-C., Houben J.-J., d'Hollander A.A. Large tidal volume ventilation does not improve oxygenation in morbidly obese patients during anesthesia. Anesth Analg. 81:1995;385-388.
2. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., McKee L.J., Bauer T.L., Caro J.F. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 334:1996;292-295.
3. Hamel R., McFarlane C.S., Ford-Hutchinson A.W. Late pulmonary responses induced by ascaris allergen in conscious squirrel monkeys. J Appl Physiol. 61:1986;2081-2087.
4. Hlastala M.P., Berger A.J. Physiology of respiration. 1996;Oxford University Press, New York. p. 72.
5. Hotta K., Gustafson T.A., Ortmeyer H.K., Bodkin N.L., Nicolson M.A., Hansen B.C. Regulation of obese (ob) mRNA and plasma leptin levels in rhesus monkeys. Effects of insulin, body weight, and non-insulin-dependent diabetes mellitus. J Biol Chem. 271:1996;25327-25331.
6. Jenkins S.C., Moxham J. The effects of mild obesity on lung function. Respir Med. 85:1991;309-311.
7. Krell R.D., Williams J.C., Giles R.E. Pharmacology of aerosol leukotriene C4- and D4-induced alteration of pulmonary mechanics in anesthetized Cynomolgus monkeys. Prostaglandins. 32:1986;769-780.
8. Lazarus R., Sparrow D., Weiss T. Effects of obesity and fat distribution on ventilatory function: the normative aging study. Chest. 11:1997;891-898.
9. Lumb A.B. Nunn's applied respiratory physiology. 5th ed:2000;Butterworth/Heinemann, Oxford.
10. Malo P.E. Chronological relationships between mediator release and changes in airway dynamics during an ascaris response in sensitive cynomolgus monkeys. Prostaglandins, Leukotrienes and Essent. Fatty Acids. 35:1989;105-111.
11. Pelosi P., Croci M., Ravagnan I., Tredici S., Pedoto A., Lissoni A., Gattinoni L. The effects of body mass on lung volumes, respiratory mechanics, and gas exchange during general anesthesia. Anesth Analg. 87:1998;654-660.
12. Pelosi P., Croci M., Ravagnan I., Cerisara M., Vicardi P., Lissoni A., Gattinoni L. Respiratory systems mechanics in sedated, paralyzed, morbidly obese patients. J Appl Physiol. 82:1997;811-818.
13. 2 solubility in unmodified human blood from 0 to 37°C. J Appl Physiol. 35:1973;861-869.
14. Roy R. Estimation of respiratory parameters by the method of covariance ratios. Comput Biomed Res. 7:1974;21-39.
15. Sakamoto S., Ishikawa K., Senda S., Nakajima S., Matsuo H. The effect of obesity on ventilatory response and anaerobic threshold during exercise. J Med Syst. 17:1993;227-231.
16. 2 diagram: a non-invasive measure of pulmonary oxygen exchange. Eur J Anaesthesiol. 12:1995;375-386.
17. Young S.S., Ritacco G., Skeans S., Chapman R.W. Eotaxin and nitric oxide production as markers of inflammation in allergic cynomolgus monkeys. Int Arch Allergy Immunol. 120:1999;209-217.
18. Zerah F., Harf A., Perlemuter L., Lorino H., Lorino A.-M., Atlan G. Effects of obesity on respiratory resistance. Chest. 103:1993;1470-1476.
19. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:1994;425-432.