Ectopic chromosome around centrosome in metaphase cells as a marker of high-risk human papillomavirus-associated cervical intraepithelial neoplasias

International Journal of Cancer

Volumn 106, Issue 2, 2003, Pages 167-171

  Furuta, Reiko ^a   Hirai, Yasuo ^a   Katase, Katsuyoshi ^a   Tate, Shinichi ^a   Kawaguchi, Tokuichi ^a   Akiyama, Futoshi ^a   Kato, Yo ^a   Kumada, Kazuki ^a   Iwasaka, Tsuyoshi ^b   Yaegashi, Nobuo ^c   Kanazawa, Koji ^d   Yoshikawa, Hiroyuki ^e   Kitagawa, Tomoyuki ^a  

^a CANCER INSTITUTE   (Japan)

^b SAGA UNIVERSITY   (Japan)

^c TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF THE RYUKYUS SCHOOL OF MEDICINE   (Japan)

^e University of Tsukuba School of Medicine   (Japan)

Author keywords

Centrosome; Cervical neoplasia; Ectopic chromosome; Genetic instability; Human papillomavirus

Indexed keywords

TUMOR MARKER;

ARTICLE; CANCER RISK; CARCINOGENESIS; CENTROSOME; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATION; CHROMOSOME STRUCTURE; CONDYLOMA; EARLY CANCER; ECTOPIC CHROMOSOME AROUND CENTROSOME; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN TISSUE; INVASIVE CARCINOMA; METAPHASE; PRIORITY JOURNAL; UTERINE CERVIX CARCINOGENESIS; UTERINE CERVIX CARCINOMA IN SITU; VIRUS CARCINOGENESIS; WART VIRUS;

ANEUPLOIDY; CENTROSOME; CERVICAL INTRAEPITHELIAL NEOPLASIA; CHROMOSOME ABERRATIONS; DNA, NEOPLASM; DNA, VIRAL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMAGE CYTOMETRY; IN SITU HYBRIDIZATION; METAPHASE; MITOTIC INDEX; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; POLYMERASE CHAIN REACTION; RISK FACTORS; TUMOR MARKERS, BIOLOGICAL; TUMOR VIRUS INFECTIONS; UTERINE CERVICAL NEOPLASMS;

EID: 0037817457     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11216     Document Type: Article

References (20)

1. Bosch FX, Manos MM, Munoz N, Sherman M, Jansen AM, Peto J, Schiffman MH, Moreno V, Kurman R, Shah KV, International Biological Study on Cervical Cancer (IBSCC) Study Group. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. J Natl Cancer Inst 1995;87:796-802.
2. zur Hausen H. Roots and perspectives of contemporary papillomavirus research. J Cancer Res Clin Oncol 1996;122:3-13.
3. Matsukura T, Sugase M. Identification of genital human papillomaviruses in cervical biopsy specimens: segregation of specific virus types in specific clinicopathological lesions. Int J Cancer 1995;61:13-22.
4. Remmink AJ, Walboomers JMM, Helmerhorst TJM, Voorhorst FJ, Rozendaal L, Risse EKJ, Meijer CJLM, Kenemans P. The presence of persistent high-risk HPV genotypes in dysplastic cervical lesions is associated with progressive disease: natural history up to 36 months. Int J Cancer 1995;61:306-11.
5. Sasagawa T, Dong Y-z, Saijoh K, Satake S, Tateno M, Inoue M. Human papillomavirus infection and risk determinants for squamous intraepithelial lesion and cervical cancer in Japan. Jpn J Cancer Res 1997;88:376-84.
6. zur Hausen H. Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 1991;184:9-13.
7. Lorincz AT, Reid R, Jenson AB, Greenberg MD, Lancaster W, Kurman RJ. Human papillomavirus infection of the cervix: relative risk associations of 15 common anogenital types. Obstet Gynecol 1992;79:328-37.
8. Holowaty P, Miller AB, Rohan T, To T. Natural history of dysplasia of the uterine cervix. J Natl Cancer Inst 1999;91:252-8.
9. Van Leeuwen AM, Pieters WJLM, Hollema H, Burger MPM. Atypical mitotic figures and the mitotic index in cervical intraepithelial neoplasia. Virchows Arch 1995;427:139-44.
10. Burger MPM, Van Leeuwen AM, Hollema H, Quint WGV, Pieters WJLM. Human papillomavirus type influences the extent of chromosomal lag during mitosis in cervical intraepithelial neoplasia grade III. Int J Gynecol Pathol 1997;16:10-4.
11. Claas ECJ, Quint WGV, Pieters WJLM, Burger MPM, Oosterhuis WJW, Lindeman J. Human papillomavirus and the three group metaphase figure as markers of an increased risk for the development of cervical carcinoma. Am J Pathol 1992;140:497-502.
12. Mourits MJE, Pieters WJLM, Hollema H, Burger MPM. Three-group metaphase as a morphologic criterion of progressive cervical intraepithelial neoplasia. Am J Obstet Gynecol 1992;167:591-5.
13. Pieters WJLM, Koudstaal J, Ploem-Zaayer JJ, Janssens J, Oosterhuis JW. The three-group metaphase as a morphologic indicator of high-ploidy cells in cervical intraepithelial neoplasia. Anal Quant Cytol Histol 1992;14:227-32.
14. Furuta R, Akiyama F, Katase K, Hirai Y, Kato Y, Kitagawa T. Ectopic assembly of chromosomes around centrosomes in metaphase cells of high-risk human papillomavirus-infected cervical dysplasia. In: Proc 60 Ann Meeting Jap Cancer Assoc, 2001;301.
15. Richart RM. Cervical intraepithelial neoplasia. Pathol Annu 1973;8:301-28.
16. Yoshikawa H, Kawana T, Kitagawa K, Mizuno M, Yoshikura H, Iwamoto A. Detection and typing of multiple genital human papillomaviruses by DNA amplification with consensus primers. Jpn J Cancer Res 1991;82:524-31.
17. Rubio CA. Atypical mitoses in colorectal adenomas. Pathol Res Pract 1991;187:508-13.
18. Duensing S, Lee LY, Duensing A, Basile J, Piboonniyom SO, Gonzalez S, Crum CP, Munger K. The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. Proc Natl Acad Sci USA 2000;97:10002-7.
19. Duensing S, Duensing A, Crum CP, Munger K. Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype. Cancer Res 2001;61:2356-60.
20. Duensing S, Munger K. The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability. Cancer Res 2002;62:7075-81.