메뉴 건너뛰기




Volumn 9, Issue 5, 2002, Pages 337-345

Chimeric G-protein-coupled receptors: Critical new tools in drug discovery

Author keywords

And drug discovery; Chimeric receptors; G proteins; Heterotrimeric G proteins; Orphan receptors; Receptors

Indexed keywords

CELL SURFACE RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; G PROTEIN COUPLED RECEPTOR;

EID: 0037816525     PISSN: 1071894X     EISSN: None     Source Type: Journal    
DOI: 10.1080/10718940216624     Document Type: Review
Times cited : (3)

References (25)
  • 1
    • 0032875356 scopus 로고    scopus 로고
    • Physiological regulation of G protein-linked signaling
    • Morris, A.J. and Malbon, C.C. (1999). Physiological regulation of G protein-linked signaling. Physiol. Rev., 79, 1373-1430.
    • (1999) Physiol. Rev. , vol.79 , pp. 1373-1430
    • Morris, A.J.1    Malbon, C.C.2
  • 3
    • 0029774791 scopus 로고    scopus 로고
    • The C-terminal third of the human luteinizing hormone (LH) receptor is important for inositol phosphate release: Analysis using chimeric human LH/follicle-stimulating hormone receptors
    • Hirsch, B., Kudo, M., Naro, F., Conti, M., and Hsueh, A.J. (1996). The C-terminal third of the human luteinizing hormone (LH) receptor is important for inositol phosphate release: analysis using chimeric human LH/follicle-stimulating hormone receptors. Mol. Endocrinol., 10, 1127-1137.
    • (1996) Mol. Endocrinol. , vol.10 , pp. 1127-1137
    • Hirsch, B.1    Kudo, M.2    Naro, F.3    Conti, M.4    Hsueh, A.J.5
  • 4
    • 0032504237 scopus 로고    scopus 로고
    • G protein-coupled receptors. I. Diversity of receptor-ligand interactions
    • Ji, T.H., Grossmann, M., and Ji, I. (1998). G protein-coupled receptors. I. Diversity of receptor-ligand interactions. J. Biol. Chemi., 273, 17299-17302.
    • (1998) J. Biol. Chemi. , vol.273 , pp. 17299-17302
    • Ji, T.H.1    Grossmann, M.2    Ji, I.3
  • 6
    • 0023945272 scopus 로고
    • Identification and sequence of a binding site peptide of the beta 2-adrenergic receptor
    • Dohlman, H.G., Caron, M.G., Strader, C.D., Amlaiky, N., Lefkowitz, and R.J. (1988). Identification and sequence of a binding site peptide of the beta 2-adrenergic receptor. Biochemistry, 27, 1813-1817.
    • (1988) Biochemistry , vol.27 , pp. 1813-1817
    • Dohlman, H.G.1    Caron, M.G.2    Strader, C.D.3    Amlaiky, N.4    Lefkowitz, R.J.5
  • 7
    • 0027157058 scopus 로고
    • A D1/D2 chimeric dopamine receptor mediates a D1 response to a D2-selective agonist
    • MacKenzie, R.G., Steffey, M.E., Manelli, A.M., Pollock, N.J., and Frail, D.E. (1993). A D1/D2 chimeric dopamine receptor mediates a D1 response to a D2-selective agonist. FEBS Lett., 323, 59-62.
    • (1993) FEBS Lett. , vol.323 , pp. 59-62
    • MacKenzie, R.G.1    Steffey, M.E.2    Manelli, A.M.3    Pollock, N.J.4    Frail, D.E.5
  • 8
    • 0024230990 scopus 로고
    • Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors
    • Frielle, T., Daniel, K.W., Caron, M.G., and Lefkowitz, R.J. (1988). Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors. Proc. Natl. Acad. Sci. USA, 85, 9494-9498.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 9494-9498
    • Frielle, T.1    Daniel, K.W.2    Caron, M.G.3    Lefkowitz, R.J.4
  • 9
    • 0028947674 scopus 로고
    • The third intracellular loop of the 5-hydroxytryptamine2A receptor determines effector coupling specificity
    • Oksenberg, D., Havlik, S., Peroutka, S.J., and Ashkenazi, A. (1995). The third intracellular loop of the 5-hydroxytryptamine2A receptor determines effector coupling specificity. Journal of Neurochemistry, 64, 1440-1447.
    • (1995) Journal of Neurochemistry , vol.64 , pp. 1440-1447
    • Oksenberg, D.1    Havlik, S.2    Peroutka, S.J.3    Ashkenazi, A.4
  • 10
    • 0028973233 scopus 로고
    • Identification of a Gs coupling domain in the amino terminus of the third intracellular loop of the alpha 2A-adrenergic receptor. Evidence for distinct structural determinants that confer Gs versus Gi coupling
    • Eason, M.G. and Liggett, S.B. (1995). Identification of a Gs coupling domain in the amino terminus of the third intracellular loop of the alpha 2A-adrenergic receptor. Evidence for distinct structural determinants that confer Gs versus Gi coupling. J. Biol. Chemi., 270, 24753-24760.
    • (1995) J. Biol. Chemi. , vol.270 , pp. 24753-24760
    • Eason, M.G.1    Liggett, S.B.2
  • 11
    • 0025212680 scopus 로고
    • Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function
    • Cotecchia, S., Exum, S., Caron, M.G., and Lefkowitz, R.J. (1990). Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function. Proc. Natl. Acad. Sci. USA, 87, 2896-2900.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 2896-2900
    • Cotecchia, S.1    Exum, S.2    Caron, M.G.3    Lefkowitz, R.J.4
  • 12
    • 0031741572 scopus 로고    scopus 로고
    • Dopamine D1B receptor chimeras reveal modulation of partial agonist activity by carboxyl-terminal tail sequences
    • Sugamori, K.S., Scheideler, M.A., Vernier, P., and Niznik, H.B. (1998). Dopamine D1B receptor chimeras reveal modulation of partial agonist activity by carboxyl-terminal tail sequences, Journal of Neurochemistry, 71, 2593-2599.
    • (1998) Journal of Neurochemistry , vol.71 , pp. 2593-2599
    • Sugamori, K.S.1    Scheideler, M.A.2    Vernier, P.3    Niznik, H.B.4
  • 13
    • 0032541084 scopus 로고    scopus 로고
    • G protein-coupled receptors. II. Mechanism of agonist activation
    • Gether, U. and Kobilka, B.K. (1998). G protein-coupled receptors. II. Mechanism of agonist activation. J. Biol. Chemi., 273, 17979-17982.
    • (1998) J. Biol. Chemi. , vol.273 , pp. 17979-17982
    • Gether, U.1    Kobilka, B.K.2
  • 14
    • 0024325514 scopus 로고
    • Site-directed anti-peptide antibodies define the topography of the beta-adrenergic receptor
    • Wang, H., Lipfert, L., Malbon, C.C., and Bahouth, S. (1989). Site-directed anti-peptide antibodies define the topography of the beta-adrenergic receptor. J. Biol. Chemi., 264, 14424-14431.
    • (1989) J. Biol. Chemi. , vol.264 , pp. 14424-14431
    • Wang, H.1    Lipfert, L.2    Malbon, C.C.3    Bahouth, S.4
  • 15
    • 0033405618 scopus 로고    scopus 로고
    • Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat
    • Liu, X., Liu, T., Slusarski, D.C., Yang-Snyder, J., Malbon, C.C., Moon, R.T., and Wang, H. (1999). Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat. Proc. Natl. Acad. Sci. USA, 96, 14383-14388.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 14383-14388
    • Liu, X.1    Liu, T.2    Slusarski, D.C.3    Yang-Snyder, J.4    Malbon, C.C.5    Moon, R.T.6    Wang, H.7
  • 16
    • 0031456158 scopus 로고    scopus 로고
    • Wnt signaling: A common theme in animal development
    • Cadigan, K.M. and Nusse, R. (1997). Wnt signaling: a common theme in animal development. Genes & Development, 11, 3286-3305.
    • (1997) Genes & Development , vol.11 , pp. 3286-3305
    • Cadigan, K.M.1    Nusse, R.2
  • 17
    • 0032510020 scopus 로고    scopus 로고
    • Wingless signaling: The inconvenient complexities of life
    • Cox, R.T. and Peifer, M. (1998). Wingless signaling: the inconvenient complexities of life. Current Biology, 8, R140-R144.
    • (1998) Current Biology , vol.8
    • Cox, R.T.1    Peifer, M.2
  • 18
    • 0031128225 scopus 로고    scopus 로고
    • WNTs modulate cell fate and behavior during vertebrate development
    • Moon, R.T., Brown, J.D., and Torres, M. (1997). WNTs modulate cell fate and behavior during vertebrate development. Trends Gen., 13, 157-162.
    • (1997) Trends Gen. , vol.13 , pp. 157-162
    • Moon, R.T.1    Brown, J.D.2    Torres, M.3
  • 20
    • 0030265570 scopus 로고    scopus 로고
    • A frizzled homolog functions in a vertebrate Wnt signaling pathway
    • Yang-Snyder, J., Miller, J.R., Brown, J.D., Lai, C.J., and Moon, R.T. (1996) A frizzled homolog functions in a vertebrate Wnt signaling pathway. Current Biology, 6, 1302-1306.
    • (1996) Current Biology , vol.6 , pp. 1302-1306
    • Yang-Snyder, J.1    Miller, J.R.2    Brown, J.D.3    Lai, C.J.4    Moon, R.T.5
  • 21
    • 0035368394 scopus 로고    scopus 로고
    • G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway
    • Liu, T., DeCostanzo, A.J., Liu, X., Wang, H., Hallagan, S., Moon, R.T., and Malbon, C.C. (2001). G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway. Science, 292, 1718-1722.
    • (2001) Science , vol.292 , pp. 1718-1722
    • Liu, T.1    DeCostanzo, A.J.2    Liu, X.3    Wang, H.4    Hallagan, S.5    Moon, R.T.6    Malbon, C.C.7
  • 22
    • 0033585001 scopus 로고    scopus 로고
    • Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via pathways that require Galpha(q) and Galpha(o) function
    • Liu, T., Liu, X., Wang, H., Moon, R.T., and Malbon, C.C. (1999). Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via pathways that require Galpha(q) and Galpha(o) function. J. Biol. Chemi., 274, 33539-33544.
    • (1999) J. Biol. Chemi. , vol.274 , pp. 33539-33544
    • Liu, T.1    Liu, X.2    Wang, H.3    Moon, R.T.4    Malbon, C.C.5
  • 23
    • 0343293801 scopus 로고    scopus 로고
    • Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus
    • Kuhl, M., Sheldahl, L.C., Malbon, C.C., and Moon, R.T. (2000). Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J. Biol. Chem., 275, 12701-12711.
    • (2000) J. Biol. Chem. , vol.275 , pp. 12701-12711
    • Kuhl, M.1    Sheldahl, L.C.2    Malbon, C.C.3    Moon, R.T.4
  • 24
    • 0029656276 scopus 로고    scopus 로고
    • Regulation of the G-protein-coupled alpha-factor pheromone receptor by phosphorylation
    • Chen, Q. and Konopka, J.B. (1996). Regulation of the G-protein-coupled alpha-factor pheromone receptor by phosphorylation. Mol. Cell Biol., 16, 247-257.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 247-257
    • Chen, Q.1    Konopka, J.B.2
  • 25
    • 0026052120 scopus 로고
    • S. cerevisiae alpha pheromone receptors activate a novel signal transduction pathway for mating partner discrimination
    • Jackson, C.L., Konopka, J.B., and Hartwell, L.H. (1991). S. cerevisiae alpha pheromone receptors activate a novel signal transduction pathway for mating partner discrimination. Cell, 67, 389-402.
    • (1991) Cell , vol.67 , pp. 389-402
    • Jackson, C.L.1    Konopka, J.B.2    Hartwell, L.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.