Tyrphostin A23 inhibits internalization of the transferrin receptor by perturbing the interaction between tyrosine motifs and the medium chain subunit of the AP-2 adaptor complex

Journal of Biological Chemistry

Volumn 278, Issue 14, 2003, Pages 12022-12028

  Banbury, David N ^b   Oakley, Jacqueline D ^b   Sessions, Richard B ^b   Banting, George ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

HYDROPHOBICITY; MEMBRANES; MORPHOLOGY; PROTEINS; YEAST;

TRANSFERRIN RECEPTORS;

BIOCHEMISTRY;

ADAPTOR PROTEIN; TRANSCRIPTION FACTOR AP 2; TRANSFERRIN RECEPTOR; TYROSINE; TYRPHOSTIN; TYRPHOSTIN A23; UNCLASSIFIED DRUG; ALEXA594; DEXTRAN; DIAGNOSTIC AGENT; ENZYME INHIBITOR; FLUORESCENT DYE; ORGANIC COMPOUND; RADIOACTIVE IODINE;

ARTICLE; CHEMICAL STRUCTURE; CONSENSUS SEQUENCE; CONTROLLED STUDY; CYTOSOL; ENDOCYTOSIS; ENZYME ACTIVE SITE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HYDROPHOBICITY; INTERNALIZATION; INTRACELLULAR MEMBRANE; MEMBRANE TRANSPORT; MEMBRANE VESICLE; MOLECULAR MODEL; PHOSPHORYLATION; PRIORITY JOURNAL; TWO HYBRID SYSTEM; BINDING SITE; CELL LINE; CHEMISTRY; DRUG EFFECT; ENDOSOME; IN VITRO STUDY; METABOLISM; PROTEIN TERTIARY STRUCTURE; TRANS GOLGI NETWORK;

EUKARYOTA;

ADAPTOR PROTEIN COMPLEX 2; BINDING SITES; CELL LINE; DEXTRANS; ENDOCYTOSIS; ENDOSOMES; ENZYME INHIBITORS; FLUORESCENT DYES; IODINE RADIOISOTOPES; MODELS, MOLECULAR; ORGANIC CHEMICALS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, TRANSFERRIN; TRANS-GOLGI NETWORK; TYROSINE; TYRPHOSTINS;

EID: 0037809214     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211966200     Document Type: Article

References (43)

1. Trowbridge, I. S., Collawn, J. F., and Hopkins, C. R. (1993) Annu. Rev. Cell Biol. 9, 129-161
2. Marks, M. S., Ohno, H., Kirchhausen, T., and Bonifacino, S. J. (1997) Trends Cell Biol. 7, 124-128
3. Pearse, B. M. F., and Robinson, M. S. (1990) Annu. Rev. Cell Biol. 6, 151-171
4. Ohno, H., Stewart, J., Fournier, M.-C., Bosshart, H., Rhee, I., Miyatake, S., Saito, T., Gallusser, A., Kirchhausen, T., and Bonifacino, J. S. (1995) Science 269, 1872-1875
5. Ohno, H., Fournier, M.-C., Poy, G., and Bonifacino, J. S. (1996) J. Biol. Chem. 271, 29009-29015
6. Boll, W., Ohno, H., Zhou, S. Y., Rapoport, I., Cantley, L. C., Bonifacino, J. S., and Kirchhausen, T. (1996) EMBO J. 15, 5789-5795
7. Marks, M. S., Woodruff, L., Ohno, H., and Bonifacino, J. S. (1996) J. Cell Biol. 135, 341-354
8. Stephens, D. J., Crump, C. M., Clarke, A. R., and Banting, G. (1997) J. Biol. Chem. 272, 14104-14109
9. Honing, S., Griffith, J., Geuze, H. J., and Hunziker, W. (1996) EMBO J. 15, 5230-5239
10. Boehm, M., and Bonifacino, J. S. (2001) Mol. Biol. Cell 12, 2907-2920
11. Kirchhausen, T. (1999) Ann. Rev. Cell Dev. Biol. 15, 705-732
12. Lewin, D. A., and Mellman, I. (1998) Biochim. Biophys. Acta 1401, 129-145
13. Robinson, M. S., and Bonifacino, J. S. (2001) Curr. Opin. Cell Biol. 13, 444-453
14. Dell'Angelica, E. C., Ohno, H., Ooi, C. E., Rabinovich, E., Roche, K. W., and Bonifacino, J. S. (1997) EMBO J. 16, 917-928
15. Stephens, D. J., and Banting, G. (1998) Biochem. J. 335, 567-572
16. Collawn, J. F., Stangel, M., Kuhn, L., Esekogwu, V., Jing, S., Trowbridge, I. S., and Tainer, J. A. (1989) Cell 63, 1061-1072
17. Eberle, W., Sander, C., Klaus, W., Schmidt, B., von Figura, K., and Peters, C. (1991) Cell 67, 1203-1209
18. Bansal, A., and Gierasch, L. M. (1991) Cell 67, 1195-1201
19. Wilde, A., Dempsey, C., and Banting, G. (1994) J. Biol. Chem. 269, 7131-7136
20. Owen, D. J., and Evans, P. R. (1998) Science 282, 1327-1332
21. Zhou, S. Y., Shoelson, S. E., Chaudhuri, M., Gish, G., Pawson, T., and Haser, W. G. (1993) Cell 72, 767-778
22. Stephens, D. J., and Banting, G. (1997) FEBS Lett. 416, 27-29
23. Shiratori, T., Miyatake, S., Ohno, H., Nakaseko, C., Isono, K., Bonifacino, J. S., and Saito, T. (1997) Immunity 6, 583-589
24. Chuang, E., Alegre, M. L. Duckett, C. S., Noel, P. J., and VanderHeiden, M. G. (1997) J. Immunol. 159, 144-151
25. Yaish, P., Gazit, A., Gilon, C., Levitzki, A., Lyall, R. M., and Zilberstein, A. (1988) Science 242, 933-935
26. Lyall, R. M., Zilberstein, A., Gazit, A., Gilon, C., Levitzki, A., and Schlessinger, J. (1989) J. Biol. Chem. 264, 14503-14509
27. Gazit, A., Yaish, P., Gilon, C., and Levitzki, A. (1989) J. Med. Chem. 32, 2344-2352
28. Holen, I., Stromhaug, P. E., Gordon, P. B., Fengsrud, M., Berg, T. O., and Seglen, P. O. (1995) J. Biol. Chem. 270, 12823-12831
29. Austin, C. D., and Shields, D. (1996) J. Cell Biol. 135, 1471-1483
30. Banting, G., and Ponnambalam, S. (1997) Biochim. Biophys. Acta 1355, 209-217
31. Bos, K., Wraight, C., and Stanley, K. K. (1993) EMBO J. 12, 2219-2228
32. Wong, S. H., and Hong, W. J. (1993) J. Biol. Chem. 268, 22853-22862
33. Humphrey, J. S., Peters, P. J., Yuan, L. C., and Bonifacino, J. S. (1993) J. Cell Biol. 120, 1123-1135
34. Roquemore, E. P., and Banting, G. (1998) Mol. Biol. Cell 9, 2125-2144
35. Crump, C., Williams, J. L., Stephens, D. J., and Banting, G. (1998) J. Biol. Chem. 273, 28073-28077
36. Collawn, J. F., Lai, A., Domingo, D., Fitch, M., Hatton, S., and Trowbridge, I. S. (1993) J. Biol. Chem. 268, 21686-21692
37. Damke, H., Baba, T., Warnock, D. E., and Schmid, S. L. (1994) J. Cell Biol. 127, 915-934
38. McGraw, T. E., and Subtil, A. (1999) Current Protocols in Cell Biology (Bonifacino, J. S., Dasso, M., Harford, J. B., Lippincott-Schwartz, J., and Yamada, K. M., eds), pp. 15.3.1-15.3.23, John Wiley & Sons, Inc., New York
39. Harlow, E., and Lane, D. (1988) Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
40. Walker, J., Watson, J., Holmes, C., Edelman, A., and Banting, G. (1995) J. Cell Sci. 108, 2433-2444
41. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
42. White, S., Miller, K., Hopkins, C. R., and Trowbridge, I. S. (1992) Biochim. Biophys. Acta 1136, 28-34
43. Nesterov, A., Carter, R. E., Sorkina, T., Gill, G. N., and Sorkin, A. (1999) EMBO J. 18, 2489-2499