Characteristics of EPI-hNE4 aerosol: A new elastase inhibitor for treatment of cystic fibrosis

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 16, Issue 2, 2003, Pages 121-129

  Grimbert, D ^a   Vecellio, L ^a   Delepine P ^a   Attucci, S ^a   Boissinot, E ^a   Poncin, A ^b   Gauthier, F ^a   Valat, C ^a   Saudubray, F ^c   Antonioz, P ^a   Diot, Patrice ^a,d  

^a INSERM   (France)

^b EUROGENTEC S A   (Belgium)

^c DEBIOPHARM SA   (Switzerland)

^d CHU BRETONNEAU   (France)

Author keywords

Aerosol; Cystic fibrosis; Elastase inhibitor; Nebulization

Indexed keywords

EPI HNE4; HUMAN SERUM ALBUMIN TC 99M; LEUKOCYTE ELASTASE INHIBITOR; UNCLASSIFIED DRUG;

AEROSOL; ARTICLE; CONCENTRATION RESPONSE; CYSTIC FIBROSIS; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG MIXTURE; DRY DEPOSITION; KINETICS; MOLECULAR DYNAMICS; NEBULIZATION; PARTICLE SIZE; PROTEIN PURIFICATION; REPRODUCIBILITY;

ADMINISTRATION, INHALATION; AEROSOLS; CYSTIC FIBROSIS; EQUIPMENT DESIGN; HUMANS; LINEAR MODELS; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; PROTEINS;

EID: 0037794398     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/089426803321919889     Document Type: Article

References (18)

1. Moltyaner, Y., G. Kent, V. Cherapanov, et al. 1999. Dysregulation of pulmonary inflammation in cystic fibrosis. Am. J. Respir. Crit. Care Med. 159:A269.
2. Tabary, O., J.M. Zahm, J. Hinnrasky, et al. 1998. Selective up-regulation of chemokine Il-8 expression in cystic fibrosis gland cells in vivo and in vitro. Am. J. Pathol. 153:921-930.
3. Khan, T.Z., J.S. Wagener, T. Bost, et al. 1995. Early pulmonary inflammation in infants with cystic fibrosis. Am. J. Respir. Crit. Care Med. 151:1075-1082.
4. Baggiolini, M., A. Walz, and S.L. Kunkel. 1989. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J. Clin. Invest. 84:1045-1049.
5. Richman-Eisenstat, J.B.Y., P.G. Jorens, C.A. Hebert, et al. 1993. Interleukin-8: an important chemoattractant in sputum of patients with chronic inflammatory airway disease. Am. J. Physiol. 264:L413-L418.
6. Brown, K., H. Wyatt, J.F. Price, et al. 1996. Pulmonary dysfunction in cystic fibrosis is associated with oxidative stress. Eur. Respir. J. 9:334-339.
7. Owen, C.A., and E. Campbell. 1999. The cell biology of leukocyte-mediated protelolysis. J. Leuk. Biol. 65:137-150.
8. Roberts, B.L., W. Markland, and A.C. Ley. 1992. Directed evolution of a protein: selection of potent neutrophil elastase inhibitors displayed on M13 fusion phage. Proc. Natl. Acad. Sci. USA 89:2429-2433.
9. Cantin, A.M., and D.E. Woods. 1999. Aerosolized prolastin suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection. Am. J. Respir. Crit. Care Med. 160:1130-1135.
10. Diot, P., L.B. Palmer, A. Smaldone, et al. 1997. RhDNase I aerosol deposition and related factors in cystic fibrosis. Am. J. Respir. Crit. Care. Med. 156:1662-1668.
11. Ramsey, B.W., M.S. Pepe, J.M. Quan, et al. 1999. Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. N. Engl. J. Med. 340:23-30.
12. Smaldone, G.C. 1991. Drug delivery via aerosol systems: concept of "aerosol inhaled." J. Aerosol Med. 4:229-235.
13. Diot, P., F. Gagnadoux, C. Martin, et al. 1997. Nebulization anti Pseudomonas aeruginosa activity of colistin. Eur. Respir. J. 10:1995-1998.
14. Vecellio None, L., D. Grimbert, M.H. Becquemin, et al. 2001. Validation of laser diffraction as an alternative method to cascade impaction in the European project of nebulizer standard. J. Aerosol. Med. 14:107-114.
15. Quittner, A. 2002. Advances in the measurement and treatment of adherence problems. Rates of adherence and new efforts to intervene. Presented at the XVIth Annual North American Cystic Fibrosis Conference, New Orleans, October 3-6.
16. Koch, C., and N. Hoiby. 1993. Pathogenesis of cystic fibrosis. Lancet. 341:1065-1069.
17. Dequin, P.F., F. Delatour, F. Faurisson, et al. 1997. Characterization on the bench of an amikacin aerosol before clinical studies. J. Aerosol. Med. 10:221-230.
18. Cipolla, C., I. Gonda, and S.J. Shire. 1994. Characterization of aerosols of human recombinant deoxyribonuclease I (rhDNase) generated by jet nebulizers. Pharmacol. Res. 11:491-498.