Spirocyclopropyl β-lactams as mechanism-based inhibitors of serine β-lactamases. Synthesis by rhodium-catalyzed cyclopropanation of 6-diazopenicillanate sulfone

Journal of Medicinal Chemistry

Volumn 46, Issue 13, 2003, Pages 2569-2571

  Sandanayaka, Vincent P ^a   Prashad, Amar S ^a   Yang, Youjun ^a   Williamson, R Thomas ^a   Lin, Yang I ^a   Mansour, Tarek S ^a  

^a WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 (1 METHYL 1,2,3 TRIAZOL 4 YLMETHYLENE)PENEM 3 CARBOXYLIC ACID; 6 DIAZOPENICILLINATE SULFONE; AMINO ACID; BETA LACTAM DERIVATIVE; BETA LACTAMASE; BETA LACTAMASE AMPC; BETA LACTAMASE INHIBITOR; CARBENOID; CEFOTAXIME; PENAM DERIVATIVE; PIPERACILLIN; RHODIUM; SERINE BETA LACTAMASE INHIBITOR; SPIROCYCLOPROPYL BETA LACTAM; SPIROCYCLOPROPYLPENAM SULFONE DERIVATIVE; SULBACTAM; TAZOBACTAM; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CATALYSIS; CROSS LINKING; CYCLOPROPANATION; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; BETA-LACTAMS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYCLOPROPANES; DIAZONIUM COMPOUNDS; ENZYME INHIBITORS; ESCHERICHIA COLI; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PSEUDOMONAS AERUGINOSA; RHODIUM; SERINE; SERRATIA MARCESCENS; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; SULBACTAM;

EID: 0037777754     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm034056q     Document Type: Article

References (21)

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