6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C β-lactamases II

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 7, 1999, Pages 997-1002

  Bitha, Panayota ^a   Li, Zhong ^a   Francisco, Gerardo D ^a   Yang, Youjun ^a   Petersen, Peter J ^a   Lenoy, Eileen ^a   Lin, Yang I ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 AMINOPENICILLANIC ACID; AMOXICILLIN; AMPICILLIN; BETA LACTAMASE INHIBITOR; CEPHALOSPORINASE; CLAVULANIC ACID; PIPERACILLIN; RO 48 1220; SULBACTAM; SULFONE DERIVATIVE; TAZOBACTAM; TICARCILLIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; INFECTION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SERRATIA MARCESCENS; STEREOCHEMISTRY;

BETA-LACTAMASES; ENZYME INHIBITORS; ESCHERICHIA COLI; SERRATIA MARCESCENS; SULFONES;

ESCHERICHIA COLI; SERRATIA MARCESCENS;

EID: 0033526053     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00107-9     Document Type: Article

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23. 17. Molecular modelling studies using MacroModel v6.0 showed that good binding ligands fit well in the enzyme active site and remained there during the molecular dynamics simulation. Details of the molecular modelling studies will be published elsewhere.