Defective regulation of the protective IgE response against intestinal helminth Ascaris lumbricoides in malhourished children

Journal of Tropical Pediatrics

Volumn 49, Issue 3, 2003, Pages 136-142

  Hagel, Isabel ^a   Lynch, N R ^a   Puccio, F ^a   Rodriguez, O ^a   Luzondo, R ^b   Rodriguez P ^c   Sanchez P ^c   Cabrera, M ^a   Di Prisco, M C ^a  

^a INSTITUTO DE BIOMEDICINA   (Venezuela)

^b Elias Toro Children's Hospital   (Venezuela)

^c Municipal Blood Bank   (Venezuela)

Author keywords

[No Author keywords available]

Indexed keywords

CD20 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4;

AGE; ARTICLE; ASCARIASIS; ASCARIS LUMBRICOIDES; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; BODY HEIGHT; BODY WEIGHT; CELL COUNT; CELL MATURATION; CHILD CARE; CLINICAL ARTICLE; DISEASE SEVERITY; HELMINTH; HELPER CELL; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; IMMUNOREGULATION; INFECTION SENSITIVITY; INTESTINE INFECTION; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MALNUTRITION; MEMORY CELL; NUTRITIONAL STATUS; PRESCHOOL CHILD; RECEPTOR AFFINITY; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; VENEZUELA;

ANALYSIS OF VARIANCE; ANIMALS; ANTIBODIES, HELMINTH; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ASCARIASIS; ASCARIS LUMBRICOIDES; CHILD; FECES; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-4; LYMPHOCYTE COUNT; NUTRITION DISORDERS; PARASITE EGG COUNT; RADIOIMMUNOSORBENT TEST; VENEZUELA;

EID: 0037773254     PISSN: 01426338     EISSN: None     Source Type: Journal    
DOI: 10.1093/tropej/49.3.136     Document Type: Article

References (30)

1. Capron M, Capron A. Immunoglobulin E and effector cells in schistosomiasis. Science 1994; 264: 1876-77.
2. King CL, Xianli J, Malhotra I. Mice with a targeted deletion of the IgE gene have increased worm burdens and reduced granulomatous inflammation following primary infection with Schistosoma mansoni. J Immunol 1997; 58: 294-300.
3. Hagel I, Lynch NR, Di Prisco MC, et al. Ascaris reinfection of slum children: Relation with the IgE response. Clin Exp Immunol 1993; 94: 80-3.
4. Webster M, Fulford AJ, Braun G, et al. Human immunoglobulin E responses to a recombinant 22.6 kilodalton antigen from Schistosoma mansoni adult worms are associated with low intensities of reinfection after treatment. Infect Immun 1996; 64: 4042-46.
5. Hagel I, Lynch N, Pérez M, et al. Modulation of the allergic reactivity of slum children by helminthic infection. Parasite Immunol 1993; 87: 16-18.
6. Pritchard DI. Immunity to helminths: Is too much IgE parasite - rather than host protective? Parasit Immunol 1993; 15: 5-8.
7. Lynch NR, Hagel I, Palenque M, et al. Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment. J Allergy Clin Immunol 1998; 101: 217-21.
8. Hadju V, Abadi K, Stephenson LS, et al. Intestinal helminthiasis, nutritional status, and their relationship; a cross sectional study in urban school slum children in Indonesia. SE Asian J Trop Med Pub Health 1997; 26: 719-29.
9. Chandra RK. Nutrition and the immune system: an introduction. Am J Clin Nutr 1997; 66: 460S-63S.
10. Grimble RF. Malnutrition and the immune response 2. Impact of nutrients on cytokine biology in infection. Trans Royal Soc Trop Med Hyg 1994. 88: 615-19.
11. Brussow H, Sidoti J, Dirren H, Freire WB. Effect of malnutrition in Ecuadorian children on titers of serum antibodies to various microbial antigens. Clin Diag Lab Immunol 1995; 2: 62-8.
12. Redmond HP, Gallagher HJ, Shou J, et al. Antigen presentation in protein energy malnutrition. Cell Immunol 1995; 163: 80-7.
13. Hagel I, Lynch NR, Di Prisco MC, et al. Nutritional status and the IgE response against Ascaris lumbricoides in children from a tropical slum. Trans Royal Soc Trop Med Hyg 1995; 89: 566-72.
14. Hagel I, Lynch NR, Di Prisco MC, et al. Helminthic infection and anthropometric indicators in children from a tropical slum: Ascaris reinfection after anthelmintic treatment. J Trop Pediat 1999; 45: 215-20.
15. Jelliffe DB. The assessment of nutritional status of the community. WHO, Geneva, 1996; Monograph Series, No 53.
16. Gorstein J, Sullivan R, Yip R, et al. Issues in the assessment of nutritional status using anthropometry. WHO Bull 1994; 72: 273-83.
17. WHO working group. Use and interpretation of anthropometric indicators of nutritional status. WHO Bull 1986; 64: 929-41.
18. López Blanco M, Landaeta M. Manual de crecimiento y desarrollo. Caracas: Sociedad Venezolana de Puericultura y Pediatría; Capítulo de crecimiento y desarrollo, nutrición y adolescencia. Fundacredesa, Serono, 1991.
19. Ceska M, Lundkvist U. A new simple radioimmunoassay method for the determination of IgE. Immunochemistry 1972; 9: 1021-30.
20. Henchoz-Lecoanet P, Jeannin JP, Aubry P. The Epstein Barr virus binding on CD21 is involved in CD23 binding and IL-4 induced IgE and IgG4 production by human B cells. Immunology 1996; 88: 35-9.
21. Kamaoka KA, Kolb JP, Miyasaka N, et al. Purified excretory-secretory component of filarial parasite enhances FCERII/CD23 expression on human splenic B and T cells and IgE synthesis while potentiating T-helper type 2-related cytokine generation from T cells. Immunology 1994; 81: 507-12.
22. Bacharier L, Jabara H, Geha RS. Molecular mechanisms of immunoglobulin E regulation. Int Arch Allergy Immunol 1988; 115: 257-69.
23. Urban JF, Fayer R, Sullivan et al. Local Th1 and Th2 responses to parasitic infection in the intestine: regulation by IFN-γ; and IL4. Vet Immunol Imunopathol 1996; 54: 337-44.
24. Woodward BD, Bezanso KD, Hillyer LM, Lee WH. The CD45RA+ (quiescent) cellular phenotype is overabundant relative to the CD45 RA-phenotype within the involuted splenic T cell population of weanling mice subjected to wasting protein-energy malnutrition. J Nutr 1995; 125: 2471-74.
25. Ha CL, Wong SS, Gray MM, et al. Overabundance of CD45 RA(+) (quiescent-phenotype) cells within the involuted CD4(+) T-cell population follows initiation of immune depression in energy deficient weanling mice and reflects involution exclusive to the CD45 RA (-) subset. J Nutr 2001; 131: 1812-18.
26. Najera O, Gonzalez C, Toledo G, et al. CD45RA and CD45RO isoforms in infected malnourished and infected well-nourished children. Clin Exp Immunol 2001; 126: 461-65.
27. MacLennan I, Gulbranson-Judge A, Toellner K, et al. The changing performance of T and B cells for partners at T-dependent antibody responses develop. Immunol Rev 1997; 156: 53-66.
28. Lee T, Chang Yue Xie. IgE regulation by nematodes: The body fluid of Ascaris contains a B cell mitogen. J Allergy Clin Immunol 1995; 95: 1246-54.
29. Reina San Martin B, Cosson A, Minoprio P. Lymphocyte polyclonal activation: A pitfall for vaccine design against infectious agents. Parasitol Today 2000; 16: 62-7.
30. Scrimshaw NS, SanGiovanni JP. Synergism of nutrition, infection and immunity: An overview. Am J Clin Nutr 1997; 66: 464S-77S.