New heterocycle synthesis by using bifunctional reactants in MCR chemistry: The use of arylglyoxales and cinnamaldehyde in the Ugi-4CR and Passerini-3CR

Chemtracts

Volumn 16, Issue 4, 2003, Pages 233-237

  Nerdinger, Sven ^a   Beck, Barbara ^a  

^a Biovertis AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2,5 PIPERAZINEDIONE; BETA LACTAM DERIVATIVE; CHLOROACETIC ACID; CINNAMALDEHYDE DERIVATIVE; GLYOXAL DERIVATIVE; HETEROCYCLIC AMINE; OXOINDOLE; OXOPYRIDINE; PHTHALAZINONE; PIPERAZINE DERIVATIVE; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

CHEMISTRY; CYCLIZATION; DRUG DETERMINATION; DRUG RESEARCH; DRUG SYNTHESIS; REACTION ANALYSIS; REVIEW; RING CLOSING METATHESIS;

EID: 0037766153     PISSN: 14319268     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (23)

1. Barton, D.H.R. Aldrichimica Acta 1990, 23, 3.
2. (a) Semple, J.E., Owens, T.D. Nguyen, K., Levy, O.E. Org. Lett. 2000, 2, 2769;
3. (b) Zhang, J., Jacobson, A., Rusche, J.R., Herlihy, W. J. Org. Chem. 1999, 64, 1074;
4. (c) Armstrong, R.W. J. Org. Chem. 1998, 63, 867;
5. (d) Nair, L.G. Fraser-Reid, B., Szardenings, A.K. Org. Lett. 2001, 3, 317:
6. (e) Heck, S. Dömling, A. Synlett 2000 424;
7. (f) Ballini, R., Bosica, G., Conforti, M.L., Maggi, R., Mazzacani, A., Righi, P., Sartori, G. Tetrahedron Lett. 2001, 57, 1395;
8. (g) Dumetsre, P., El Kaim, L., Gregoire, A. Chem. Commun. 1999, 775;
9. (h) Shaabani, A., Yavari, I., Teimouri, M.B., Bazigir, A. Tetrahedron 2001, 57, 1375;
10. (i) Scheffler, G., Justus, M., Vasella, A. Wessel, H.P. Tetrahedron Lett. 1999, 40, 5845;
11. (j) Petasis, N.A., Patel, Z.D. Tetrahedron Lett. 2000, 41, 9607.
12. Bienaymé, H., Hulme, C., Oddon, G., Schmitt, P. Chem. Eur. J. 2000, 6, 3321.
13. Wender, P.A., Handy, S.T., Wright, D.L. Chem. Ind. 1997, 765.
14. Beck, B. Hess, S., Dömling, A. Biorg. Med. Chem. Lett. 2000, 10, 1701.
15. Dömling, A. Ugi, I. Angew. Chem. Int. Ed. Engl. 1993, 32, 563.
16. Lee, D., Sello, J.K., Schreiber, S.L. Org. Lett. 2000, 2, 709.
17. (a) Bossio, R., Marcos, C.F., Marcaccini, S., Pepino, R. Tetrahedron Lett. 1997, 38, 14, 2519;
18. (b) Bossio, R., Marcos, C.F., Marcaccini, S., Pepino, R. Synthesis 1997, 1389;
19. (c) Marcaccini, S., Pepino, R., Pozo, M.C. Tetrahedron Lett. 2001, 42, 2727.
20. Bossio, R., Marcos, C.F., Marcaccini, S., Pepino, R. Heterocycles 1997, 45, 8, 1589.
21. Marcaccini, S., Pepino, R., Pozo, M.C. Synthesis 2001, 42, 85.
22. Beck, B. Magnin-Lachaux, M., Herdtweck, E., Dömling, A. Org. Lett. 2001, 3, 2875.
23. Marcaccini, S. Pepino, R., Marcos, C.F., Polo, C., Torroba, T. J. Heterocyclic Chem. 2000, 37, 1501.