Female sexual dysfunction: Review of the disorder and evidence for available treatment alternatives

Journal of Pharmacy Practice

Volumn 16, Issue 3, 2003, Pages 200-208

  Miller, Heather B ^a   Hunt, Jacquelyn S ^a  

^a St John Providence Health System   (United States)

Author keywords

Female sexual arousal disorder; Female sexual dysfunction; Libido

Indexed keywords

4 AMINOBUTYRIC ACID; AMANTADINE; AMFEBUTAMONE; ANDROSTENEDIONE; ANTIDEPRESSANT AGENT; ARGININE; CONJUGATED ESTROGEN; CYPROHEPTADINE; ESTRADIOL; ESTROGEN; HERBACEOUS AGENT; HISTIDINE; LEVONORGESTREL; METHYLTESTOSTERONE; NICOTINIC ACID; ORNITHINE; PHENTOLAMINE MESYLATE; POLLEN EXTRACT; PRASTERONE; PREGNENOLONE; PROGESTERONE; PROSTAGLANDIN E1; SABAL EXTRACT; SEROTONIN UPTAKE INHIBITOR; SILDENAFIL; TESTOSTERONE; TESTOSTERONE ENANTATE; YOHIMBINE;

ANAMNESIS; CLINICAL TRIAL; COUNSELING; DRUG SCREENING; ESTROGEN THERAPY; FEMALE; FEMALE SEXUAL DYSFUNCTION; FUNCTIONAL ANATOMY; HORMONAL THERAPY; HUMAN; HUMAN RELATION; HYPERCHOLESTEROLEMIA; HYSTERECTOMY; PATHOPHYSIOLOGY; PHYSICAL EXAMINATION; PHYSIOLOGY; POSTMENOPAUSE; PREVALENCE; REVIEW; SEX THERAPY;

EID: 0037764054     PISSN: 08971900     EISSN: None     Source Type: Journal    
DOI: 10.1177/0897190003016003008     Document Type: Review

References (49)

1. Laumann EO, Paik A, Rose RC. Sexual dysfunction in the United States: prevalence and predictors. JAMA. 1999;281:537-544.
2. Berman JR, Adhikari SP, Goldstein I. Anatomy and physiology of female sexual function and dysfunction: classification, evaluation and treatment options. Eur Urol. 2000;38:20-29.
3. Leiblum SR. Definition and classification of female sexual disorders. Int J Impot Res. 1998;10(suppl 2):S104-S106.
4. Writing Group for the Women’s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women’s health initiative randomized controlled trial. JAMA. 2002;288:321-333.
5. Hulley S, Furberg C, Barrett-Connor E, et al. Noncardiovascular disease outcomes during 6.8 years of hormone therapy: heart and estrogen/progestin replacement study follow-up (HERS II). JAMA. 2002;288:58-66.
6. Grady D, Herrington D, Bittner V, et al. Cardiovascular disease outcomes during 6.8 years of hormone therapy: heart and estrogen/progestin replacement study follow-up (HERS II). JAMA. 2002;288:49-57.
7. Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA. 1998;280:605-613.
8. Berman JR, Goldstein I. Female sexual dysfunction. Urol Clin N Am. 2001;28:405-416.
9. Meston CM. The psychophysiological assessment of female sexual dysfunction. J Sex Education & Therapy. 2000;25:6-16.
10. Guyton AC. Pregnancy, reproductive functions of the female, and female hormones. In: Guyton AC, ed. Textbook of Medical Physiology. Philadelphia, Pa: WB Saunders; 1981:1017-1018.
11. Baram DA. Sexuality and sexual function. In: Berek JS, Adashi EY, Hilard PA, eds. Novak’s Gynecology. 12th ed. Baltimore, Md: Williams & Wilkins; 1996:281-282.
12. Saks BR. Identifying and discussing sexual dysfunction. J Clin Psychiatry. 1999;17:4-8.
13. Meston CM, Frohlich PF. Update on female sexual function. Curr Opin Urol. 2001;11:603-609.
14. Meston CM, Frohlich PE The neurobiology of sexual function. Arch Gen Psychiatry. 2000;57:1012-1030.
15. Nusbaum MRH, Hamilton C, Lenahan P. Chronic illness and sexual functioning. Am Fam Physician. 2003;67:347-354.
16. American Psychiatric Association. DSM-IV: Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Press; 1994:493-538.
17. Basson R, Berman J, Burnett A, et al. Report of the International Consensus Development Conference on female sexual dysfunction: definitions and classifications. J Urol. 2000;163:888-893.
18. Hershlag A, Peterson CM. Endocrine disorders. In: Berek JS, Adashi EY, Hilard PA, eds. Novak’s Gynecology. 12th ed. Baltimore, Md: Williams & Wilkins; 1996:836.
19. Phillips NA. Female sexual dysfunction: evaluation and treatment. Am Fam Physician. 2000;62:127-137.
20. Tuiten A, Van Honk J, Koppeschaar H, Bernaards C, Thijssen J, Verbaten R. Time course of effects of testosterone administration on sexual arousal in women. Arch Gen Psychiatry. 2000;57:149-153.
21. Phillips RL, Slaughter J. Depression and sexual desire. Am Fam Physician. 2000;62:782-786.
22. http://www.urometrics.com/products/eros/hcpro.html. Accessed January 15, 2003.
23. Sarrell P. Progestogens and blood flow. Int Proc J. 1989;1:266-271.
24. Sarrell PM. Sexuality and menopause. Obstet Gynecol. 1990;75:26S-30S.
25. Dennerstein L, Burrows GD, Wood C, Hyman G. Hormones and sexuality: effect of estrogen and progestogen. Obstet Gynecol. 1980;56:316-322.
26. Hilditch JR, Lewis J, Ross AH. A comparison of the effects of oral conjugated equine estrogen and transdermal estradiol-17-beta combined with an oral progestin on quality of life in postmenopausal women. Maturitas. 1996;24:177-184.
27. Shifren JL, Braunstein GD, Simon JA, et al. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med. 2000;343:682-688.
28. Barrett-Connor E, Young R, Notelovitz M, et al. A two-year, double-blind comparison of estrogen-androgen and conjugated estrogens in surgically menopausal women. J Reprod Med. 1999;44:1012-1020.
29. Sherwin BB, Gelfand MM, Brender W. Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause. Psychosomatic Med. 1985;47:339-351.
30. Sarrel P, Dobay B, Wiita B. Estrogen and estrogen-androgen replacement in postmenopausal women dissatisfied with estrogen-only therapy. J Reprod Med. 1998;43:847-856.
31. Bancroft JD, Davidson DW, Warner P, Tyrer G. Androgens and sexual behaviour in women using oral contraceptives. Clin Endocrinol. 1980;12:327-340.
32. Cauley JA, Lucas FL, Kuller LH, Stone K, Browner W, Cummings SR. Elevated serum estradiol and testosterone concentrations are associated with a high risk for breast cancer. Ann Intern Med. 1999;130:270-277.
33. Spark RF. Dehydroepiandrosterone: a springboard hormone for female sexuality. Fertil Steril. 2002;77(suppl 4):S19-S25.
34. Arlt W, Callies F, Van Vlijmen JC, et al. Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med. 1999;341:1013-1020.
35. Rosen RC, Lane RM, Menza M. Effects of SSRIs on sexual function: a critical review. J Clin Psychiatry. 1999;19:67-85.
36. Rothschild AJ. Selective serotonin reuptake inhibitor-induced sexual dysfunction: efficacy of a drug holiday. Am J Psychiatry. 1995;152:1514-1516.
37. Modell JG, May RS, Katholi CR. Effect of bupropion-SR on orgasmic dysfunction in nondepressed subjects: a pilot study. J Sex Marital Ther. 2000;26:231-240.
38. Woodrum ST, Brown CS. Management of SSRI-induced sexual dysfunction. Ann Pharmacother. 1998;32:1209-1215.
39. Ashton AK, Rosen RC. Bupropion as an antidote for serotonin reuptake inhibitor-induced sexual dysfunction. J Clin Psychiatry. 1998;59:112-115.
40. Labbate LA, Grimes JB, Hines A, Pollack MH. Bupropion treatment of sexual reuptake antidepressant-associated sexual dysfunction. Ann Clin Psychiatry. 1997;9:241-245.
41. Masand PS, Ashton AK, Gupta S, Frank B. Sustained-release bupropion for selective serotonin reuptake inhibitor-induced sexual dysfunction: a randomized, double-blind, placebo-controlled, parallel group study. Am J Psychiatry. 2001;158:805-807.
42. Walker PW, Cole JO, Gardner EA, et al. Improvement in fluoxetine-associated sexual dysfunction in patients switched to bupropion. J Clin Psychiatry. 1993;54:459-465.
43. Clayton AH, McGarvey EL, Abouesh AI, Pinkerton RC. Substitution of an SSRI with bupropion sustained release following SSRI-induced sexual dysfunction. J Clin Psychiatry. 2001;62:185-190.
44. Crenshaw TL, Goldberg JP, Stern WC. Pharmacologic modification of psychosexual dysfunction. J Sex Marital Ther. 1987;13:239-252.
45. Segraves RT, Croft H, Kavoussi R, et al. Bupropion sustained release (SR) for the treatment of hypoactive sexual desire disorder (HSDD) in nondepressed women. J Sex Marital Ther. 2001;27:303-316.
46. Caruso S, Intelisano G, Lupo L, Agnello C. Premenopausal women affected by sexual arousal disorder treated with sildenafil: a double-blind, cross-over, placebo-controlled study. BJOG. 2001;108:623-628.
47. Nurnberg HG, Hensley PL, Lauriello J, Parker LM, Keith SJ. Sildenafil for women patients with antidepressant-induced sexual dysfunction. Psychiatric Services. 1999;50:1076-1078.
48. Sipski ML, Rosen RC, Alexander CJ, Hamer RM. Sildenafil effects on sexual and cardiovascular responses in women with spinal cord injury. Urology. 2000;55:812-815.
49. http://www.zonagen.com/html/clinical.htm. Accessed January 21, 2003.