New N-pyridinyl(methyl)-N1-substituted-3-indolepropanamides acting as topical and systemic anti-inflammatory agents

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 18, Issue 2, 2003, Pages 201-208

  Gallard, Anthony ^a   Duflos, Muriel ^a   Nourrisson, Marie Renee ^a   Le Baut, Guillaume ^a   Grimaud, Nicole ^a   Petit, Jean Yves ^a  

^a UNIVERSITÉ DE NANTES   (France)

Author keywords

N pyridinyl and N pyridinylmethyl 3 indolepropanamides; Topical and systemic inflammation inhibitors

Indexed keywords

ANTIINFLAMMATORY AGENT; DEXAMETHASONE; IBUPROFEN; METHYL GROUP; N (4,6 DIMETHYLPYRIDIN 2 YL) 3 (1 METHYLINDOL 3 YL)PROPANAMIDE; N (4,6 DIMETHYLPYRIDIN 2 YL) 3 (5 FLUORO 1 METHYLINDOL 3 YL)PROPANAMIDE; N (4,6 DIMETHYLPYRIDIN 2 YL) 3 (5 FLUOROINDOL 3 YL)PROPANAMIDE; N (4,6 DIMETHYLPYRIDIN 2 YL) 3 [1 (4 FLUOROBENZYL)INDOL 3 YL]PROPANAMIDE; N (4,6 DIMETHYLPYRIDIN 2 YL) 3 [5 FLUORO 1 (4 FLUOROBENZYL)INDOL 3 YL]PROPANAMIDE; N (PYRIDIN 3 YLMETHYL) 3 (1 METHYLINDOL 3 Y) PROPANAMIDE; N (PYRIDIN 3 YLMETHYL) 3 (5 FLUORO 1 METHYL INDOL 3 YL)PROPANAMIDE; N (PYRIDIN 3 YLMETHYL) 3 (5 FLUOROINDOL 3 YL) PROPANAMIDE; N (PYRIDIN 3 YLMETHYL) 3 (INDOL 3 YL)PROPANAMIDE; N (PYRIDIN 3 YLMETHYL) 3 [1 (4 FLUOROBENZYL) INDOL 3 YL]PROPANAMIDE; N (PYRIDIN 3 YLMETHYL) 3 [5 FLUORO 1 (4 FLUORO BENZYL)INDOL 3 YL]PROPANAMIDE; N (PYRIDIN 4 YL) 3 (1 METHYLINDOL 3 YL)PROPANAMIDE; N (PYRIDIN 4 YL) 3 (5 FLUORO 1 METHYLINDOL 3 YL)PROPANAMIDE; N (PYRIDIN 4 YL) 3 [1 (4 FLUOROBENZYL)INDOL 3 YL]PROPANAMIDE; N (PYRIDIN 4 YL) 3 [5 FLUORO 1 (4 FLUOROBENZYL) INDOL 3 YL]PROPANAMIDE; NITROGEN DERIVATIVE; PROPIONAMIDE DERIVATIVE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EAR; EDEMA; MALE; MOUSE; NONHUMAN; OTITIS; PAW EDEMA; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; EAR, EXTERNAL; EDEMA; FOOT; INDOLES; MALE; MICE; MOLECULAR STRUCTURE; PYRIDINES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TETRADECANOYLPHORBOL ACETATE;

ANIMALIA;

EID: 0037763857     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/1475636032000069873     Document Type: Article

References (10)

1. Breteche, A., Duflos, M., Dassonville, A., Nourrisson, M.R., Brelet, J., Le Baut, G., Grimaud, N. and Petit, J.Y. (2002) J. Enz. Inhib. Med. Chem. 17, 415-424.
2. Collin, X., Robert, J.M., Wielgosz, G., Le Baut, G., Bobin-Dubigeon, C., Grimaud, N. and Petit, J.Y. (2001) J. Med. Chem. 36, 639-649.
3. Hynes, J., Jr., Leftheris, K., Wu, H., Pandit, C., Chen, P., Norris, D.J., Chen, B.C., Zhao, R., Kiener, P.A., Chen, X., Turk, L.A., Patil-Koota, V., Gilloly, M., Shuster, D.J. and McIntyre, K.W. (2002) Bioorg. Med. Chem. Lett. 12, 2399-2402.
4. Zenitz, B.L. (1966) U.S. Patent 3 238, 215.
5. Menciu, C., Duflos, M., Fouchard, F., Le Baut, G., Emig, P., Achterrath, U., Szelenyi, I., Nickel, B., Schmidt, J., Kutscher, B. and Günther, E. (1999) J. Med. Chem. 42, 638-648.
6. Carlson, R.P., O'Neill-Davis, L., Chang, J. and Lewis, A.J. (1985) Agents Actions 17, 197-204.
7. Winter, C.A., Risley, E.A. and Nuss, G.W. (1962) Proc. Soc. Exp. Biol. Med. 111, 544-557.
8. Phillipe, R.R. (1959) Org. React. 10, 143-178.
9. Alford, J.G., Stanley, P.L., Todderud, G. and Tramposch, K.M. (1992) Agents Actions 37, 260-267.
10. Black, R.A., Bird, T.A. and Mohler, M.M. (1997) In: Bristol, J.A., ed, Annu. Rep. Med. Chem. (Academic Press, San Diego), 32 241-250.