New anti-inflammatory N-pyridinyl(alkyl)phthalimides acting as tumour necrosis factor-α production inhibitors

European Journal of Medicinal Chemistry

Volumn 36, Issue 7-8, 2001, Pages 639-649

  Collin, Xavier ^a   Robert, Jean Michel ^a   Wielgosz, Gaétane ^a   Le Baut, Guillaume ^a   Bobin Dubigeon, Christine ^a   Grimaud, Nicole ^a   Petit, Jean Yves ^a  

^a UNIVERSITÉ DE NANTES   (France)

Author keywords

Carrageenan induced oedema; N pyridinylphthalimides; Non acidic NSAIDs; PMA oedema; TNF inhibitors

Indexed keywords

2 (4,6 DIMETHYLPYRIDIN 2 YL) 1H ISOINDOL 1,3 DIONE; CARRAGEENAN; DEXAMETHASONE; FLUORINE DERIVATIVE; IBUPROFEN; N (2,6 DIISOPROPYLPHENYL)PHTHALIMIDE; N (PYRIDIN 3 YLMETHYL) 4,5,6,7 TETRAFLUOROPHTHALIMIDE; N PHENYL 4,5,6,7 TETRAFLUOROPHTHALIMIDE DERIVATIVE; N PYRIDINYLPHTHALIMIDE DERIVATIVE; NITROGEN; PHORBOL 13 ACETATE 12 MYRISTATE; PYRIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EAR; EDEMA; FOOT; INHIBITION KINETICS; MALE; MODULATION; MOUSE; NONHUMAN; PHARMACOPHORE; RAT; REACTION ANALYSIS; REDUCTION; THICKNESS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; EAR DISEASES; EDEMA; FOOT DISEASES; MALE; MICE; MICROBIAL SENSITIVITY TESTS; PHTHALIMIDES; PYRIDINES; RATS; RATS, WISTAR; SCHIFF BASES; TETRADECANOYLPHORBOL ACETATE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035415275     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(01)01254-5     Document Type: Article

References (26)

1. Determination of the role of TNF in inflammatory responses using a receptor fusion protein