Different actions of gabapentin and baclofen in hippocampus from weaver mice

Hippocampus

Volumn 13, Issue 4, 2003, Pages 525-528

  Bertrand, Sandrine ^a   Morin, France ^a   Lacaille, Jean Claude ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

C57BL 6 mice; GABAergic synaptic transmission; Kir3 current; Patch clamp recording; Weaver mice

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; BACLOFEN; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; BICUCULLINE; GABAPENTIN; POTASSIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DISSOCIATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; GENE MUTATION; HIPPOCAMPUS; INHIBITORY POSTSYNAPTIC POTENTIAL; MEMBRANE STEADY POTENTIAL; MOUSE; MOUSE STRAIN; NONHUMAN; PATCH CLAMP; POSTSYNAPTIC MEMBRANE; POTASSIUM CURRENT; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ACETIC ACIDS; AMINES; ANIMALS; BACLOFEN; CYCLOHEXANECARBOXYLIC ACIDS; DOWN-REGULATION; EXCITATORY AMINO ACID ANTAGONISTS; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, NEUROLOGIC MUTANTS; NEURAL INHIBITION; ORGAN CULTURE TECHNIQUES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PYRAMIDAL CELLS; RECEPTORS, GABA-B; SPECIES SPECIFICITY; SYNAPTIC TRANSMISSION;

EID: 0037746667     PISSN: 10509631     EISSN: None     Source Type: Journal    
DOI: 10.1002/hipo.10131     Document Type: Article

References (9)

1. Abraham MR, Jahangir A, Alekseev AE, Terzic A. 1999. Channelopathies of inwardly rectifying potassium channels. FASEB J 13:1901-1910.
2. Blein S, Hawrot E, Barlow P. 2000. The metabotropic GABA receptor: molecular insights and their functional consequences. Cell Mol Life Sci 57:635-650.
3. + channels composed of Kir3.2 sub-units in dopaminergic neurons of the substantia nigra. J Neurosci 19:1006-1017.
4. +-dependent inhibition in weaver hippocampus. J Neurosci 18:4001-4007.
5. Leaney JL, Tinker A. 2000. The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel. Proc Natl Acad Sci U S A 97:5651-5656.
6. + channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons. Neuron 19:687-695.
7. Neher E. 1992. Correction for liquid junction potentials in patch clamp experiments. Methods Enzymol 207:123-131.
8. Ng GY, Bertrand S, Sullivan R, Ethier N, Wang J, Yergey J, Belley M, Trimble L, Bateman K, Alder L, Smith A, McKernan R, Metters K, O'Neill GP, Lacaille JC, Hebert TE. 2001. Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action. Mol Pharmacol 59:144-152.
9. B receptors on CA1 pyramidal cells of rat hippocampal slices. J Neurophysiol 76:69-80.