Childhood leukemia: Electric and magnetic fields as possible risk factors

Environmental Health Perspectives

Volumn 111, Issue 7, 2003, Pages 962-970

  Brain, Joseph D ^a   Kavet, Robert ^b   McCormick, David L ^c   Poole, Charles ^d   Silverman, Lewis B ^e   Smith, Thomas J ^a   Valberg, Peter A ^f   Van Etten, R A ^g   Weaver, James C ^h  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b ELECTRIC POWER RESEARCH INSTITUTE   (United States)

^c IIT RESEARCH INSTITUTE   (United States)

^d IL   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

^f GRADIENT   (United States)

^g Center of Blood Research   (United States)

^h HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

Author keywords

Childhood leukemia; Contact currents; Contact voltages; Electric and magnetic fields; EMF; Review

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; BIOASSAY; BIOPHYSICS; CANCER RISK; CARCINOGENICITY; CHILD; CHILDHOOD LEUKEMIA; CORRELATION COEFFICIENT; DISEASE MODEL; ELECTRIC CURRENT; ELECTRIC POTENTIAL; ELECTROMAGNETIC FIELD; ENVIRONMENTAL EXPOSURE; EPIDEMIOLOGICAL DATA; FEMALE; HUMAN; INFANT; LEUKEMOGENESIS; MALE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL PROCESSING; STOCHASTIC MODEL;

ANIMALIA;

EID: 0037745079     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.6020     Document Type: Review

References (65)

1. Adair RK. 1991. Constraints on biological effects of weak extremely-low-frequency electromagnetic fields. Phys Rev A 43:1039-1048.
2. Adair RK. 1994. Constraints of thermal noise on the effects of weak 60-Hz magnetic fields acting on biological magnetite. Proc Natl Acad Sci USA 91:2925-2929.
3. Adair RK. 2001. Simple neural networks for the amplification and utilization of small changes in neuron firing rates. Proc Natl Acad Sci USA 98:7253-7258.
4. Adair RK, Astumian RD, Weaver JC. 1998. On the detection of weak electric fields by sharks, rays and skates. Chaos 8:576-587.
5. Ahlbom A, Cardis E, Green A, Linet M, Savitz D, Swerdlow A. 2001. Review of the epidemiologic literature on EMF and health. Environ Health Perspect 109(suppl 6):911-933.
6. Ahlbom A, Day N, Feychting M, Roman E, Skinner J, Dockerty J, et al. 2000. A pooled analysis of magnetic fields and childhood leukaemia. Br J Cancer 83:692-698.
7. Astumian RD, Weaver JC, Adair RK. 1995. Rectification and signal averaging of weak electric fields by biological cells. Proc Natl Acad Sci USA 92:3740-3743.
8. Babbitt JT, Kharazi AI, Taylor JM, Bonds CB, Mirell SG, Frumkin E, et al. 2000. Homatopoietic neoplasia in C57BL/6 mice exposed to split-dose ionizing radiation and circularly polarized 60 Hz magnetic fields. Carcinogenesis 21:1379-1389.
9. Berns A, van der Lugt N, Alkema M, van Lohuizen M, Domen J, Acton D, et al. 1994. Mouse model systems to study multi-step tumorigenesis. Cold Spring Harb Symp Quant Biol 59:435-447.
10. Boorman GA, McCormick DL, Findlay JC, Hailey JR, Gauger JR, Johnson TR, et al. 1999. Chronic toxicity/oncogenicity evaluation of 60 Hz (power frequency) magnetic fields in F344/N rats. Toxicol Pathol 27:267-278.
11. Boorman GA, Rafferty CN, Ward JM, Sills RC. 2000. Leukemia and lymphoma incidence in rodents exposed to low-frequency magnetic fields. Radiat Res 153:627-636.
12. CADHS. 2002. An Evaluation of the Possible Risks from Electric and Magnetic Fields (EMF) from Power Lines, Internal Wiring, Electrical Occupations and Appliances. Oakland, CA:California Department of Health Services, California EMF Program. Available: http://www.dhs.ca.gov/ehib/emf/RiskEvaluation/riskeval.html [accessed 19 February 2003].
13. Dawson TW, Caputa K, Stuchly MA, Kavet R. 2001. Electric fields in the human body resulting from 60-Hz contact currents. IEEE Trans Biomed Eng 48:1020-1026.
14. Donehower LA. 1996. The p53-deficient mouse: a model for basic and applied cancer studies. Semin Cancer Biol 7:269-278.
15. Draper GJ. (ed). 1991. The Geographical Epidemiology of Childhood Leukaemia and Non-Hodgkin Lymphomas in Great Britain, 1966-83, Studies on Medical and Population Subjects, No. 53. London:Her Majesty's Stationery Office.
16. Eischen CM, Weber JD, Roussel MF, Sherr CJ, Cleveland JL. 1999. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphoma genesis. Genes Dev 13:2658-2669.
17. Fear EC, Stuchly MA. 1998. Biological cells with gap junctions in low frequency electric fields, IEEE Trans Biomed Eng 45:856-866.
18. Gawande A. 1999. The cancer-cluster myth. New Yorker. 8 February, 34-37.
19. Gowrishankar TR, Weaver JC. 2003. A new approach to electrical modeling of single and multiple cells. Proc Natl Acad Sci USA 100:3203-3208.
20. Greaves MF. 1997. Aetiology of acute leukaemia. Lancet 349:344-349.
21. Greaves MF, Alexander FE. 1993. Review: an infectious etiology for common acute lymphoblastic leukemia in childhood? Leukemia 7:349-360.
22. Greenland S, Sheppard AR, Kaune WT, Poole C, Kelsh MA. 2000. A pooled analysis of magnetic fields, wire codes, and childhood leukemia. Childhood Leukemia-EMF Study Group. Epidemiology 11:624 634.
23. Harris AW, Basten A, Gebski V, Noonan D, Finnie J, Bath ML, et al. 1998. A test of lymphoma induction by long-term exposure of E mu-Pim1 transgenic mice to 50 Hz magnetic fields. Radiat Res 149:300-307.
24. Hatch EE, Kleinerman RA, Linet MS, Tarone RE, Kaune WT, Auvinen A, at al. 2000. Do confounding or selection factors of residential wiring codes and magnetic fields distort findings of electromagnetic fields studies? Epidemiology 11:189-198.
25. Higuchi M, O'Brien D, Kumaravelu P, Lenny N, Yeoh EJ, Downing JR. 2002. Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia. Cancer Cell 1:63-74.
26. Huettner CS, Zhang P, Van Etten RA, Tenen DG. 2000. Reversibility of acute B-cell leukaemia induced by BCR-ABL1. Nat Genet 24:57-60.
27. IARC. 2002. Non-ionizing radiation, part 1: static and extremely low-frequency (ELF) electric and magnetic fields. IARC Monogr Eval Carcinog Risks Hum 80:1-429.
28. Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, et al. 1994. Tumor spectrum analysis in p53-deficient mice. Curr Biol 4:1-7.
29. Kaune WT, Dovan T, Kavet RI, Savitz DA, Neutra RR. 2002. Study of high- and low-current-configuration homes from the 1988 Denver Childhood Cancer Study. Bioelectromagnetics 23:177-188.
30. Kavet R, Stuchly MA, Bailey WH, Bracken TD. 2001. Evaluation of biological effects, dosimetric models, and exposure assessment related to ELF electric- and magnetic-field guidelines. Appl Occup Environ Hyg 16:1118-1138.
31. Kavet R, Zaffanella LE. 2002. Contact voltage measured in residences: implications to the association between magnetic fields and childhood leukemia. Bioelectromagnetics 23:464-474.
32. Kavet R, Zaffanella LE, Daigle JP, Ebi KL. 2000. The possible role of contact current in cancer risk associated with residential magnetic fields. Bioelectromagnetics 21:538-553.
33. Kinlen LJ. 1995. Epidemiological evidence for an infective basis in childhood leukaemia. Br J Cancer 71:1-5.
34. Kinlen LJ. 1997. High-contact paternal occupations, infection and childhood leukaemia: five studies of unusual population-mixing of adults. Br J Cancer 76:1539-1545.
35. Kirschvink JL, Kobayashi-Kirschvink A, Woodford BJ. 1992. Magnetite biomineralization in the human brain. Proc Natl Acad Sci USA 89:7683-7687.
36. Kirschvink JL, Walker MM, Diebel CE. 2001. Magnetite-based magnetoreception: a review. Curr Opin Neurobiol 11:462-467.
37. Li S, Ilaria RL, Million RP, Daley GO, Van Etten RA. 1999. The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J Exp Med 189:1399-1412.
38. Linet MS, Ries LA, Smith MA, Tarone RE, Devesa SS, 1999. Cancer surveillance series: recent trends in childhood cancer incidence and mortality in the United States. J Natl Cancer Inst 91:1051-1058.
39. Look AT. 1997. Oncogenic transcription factors in the human acute leukemias. Science 278(5340):1059-1964.
40. Mandeville R, Franco E, Sidrac-Ghali S, Paris-Nadon L, Rocheleau N, Mercier G, et al. 1997. Evaluation of the potential carcinogenicity of 60 Hz linear sinusoical continuous-wave magnetic fields in Fischer 344 rats. FASEB J 11:1127-1136.
41. Massachusetts Department of Public Health. 1997. Woburn Childhood Leukemia Follow-up Study. Final Report. Boston, MA:Massachusetts Department of Public Health.
42. McCormick DL, Boorman GA, Findlay JC, Hailey JR, Johnson TR, Gauger JR, et al. 1999. Chronic toxicity/oncogenicity evaluation of 60 Hz (power frequency) magnetic fields in B6C3F1 mice. Toxicol Pathol 27:279-285.
43. McCormick DL, Ryan BM, Findlay JC, Gauger JR, Johnson TR, Morrissey RL, et al. 1998. Exposure to 60 Hz magnetic fields and risk of lymphoma in PIM transgenic and TSG-p53 (p53 knockout) mice. Carcinogenesis 19:1649-1653.
44. Miller RW. 1967. Persons with exceptionally high risk of leukemia. Cancer Res 27:2420-2423.
45. NCI. 2003. Surveillance, Epidemiology and End Results (SEER). Finding Cancer Statistics. Bethesda, MD:National Cancer Institute. Available: http://surveillance.cancer.gov/statistics/ [accessed 19 February 2003].
46. NIEHS. 1999. Health Effects from Exposure to Power-Line Frequency Electric and Magnetic Fields, NIH Publication 99-4493. Research Triangle Park, NC:National Institute of Environmental Health Sciences.
47. Parkin DM, Kramárová E, Draper GJ, Masuery E, Michaelis J, Neglia J, et al. (eds). 1998. International Incidence of Childhood Cancer, Vol 2. IARC Publications, No. 144. Lyon, France:International Agency for Research on Cancer.
48. Polk C. 1992. Counter ion polarization and low frequency, low electric field intensity biological effects. Bioelectrochem Bioenerget 28:279-289.
49. Polk C. 1994 Effects of extremely- low-frequency fields on biological magnetite: limitations on physical models. Bioelectromagnetics 15:261-270.
50. Pui C-H, Behm FG, Raimondi SC, Dodge RK, George SL, Rivera GK, et al. 1989. Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia. New Engl J Med 321:136-142.
51. Reilly JP. 1998. Applied Bioelectricity: From Electrical Stimulation to Electropathology, New York:Springer-Verlag.
52. Robison LL, Neglia JP. 1987. Epidemiology of Down syndrome and childhood acute leukemia. Prog Clin Biol Res 246:19-32.
53. Savitz DA. 2003. Health effects of electric and magnetic fields: are we done yet? Epidemiology 14:15-17.
54. Shen YH, Shao BJ, Chiang H, Fu YD, Yu M. 1997. The effects of 50 Hz magnetic field exposure on dimethylbenz(alpha)anthracene induced thymic lymphoma/leukemia in mice. Bioelectromagnetics 18:360-364.
55. Tucker MA, Meadows AT, Boice JD Jr, Stovall M, Oberlin O, Stone BJ, et al. 1987. Leukemia after therapy with alkylating agents for childhood cancer. J Natl Cancer Inst 78:459-464.
56. Unnikrishnan I, Radfar A, Jenab-Wolcott J, Rosenberg N. 1999. p53 mediates apoptotic crisis in primary Abelson virus-transformed pre-B cells. Mol Cell Biol 19:4825-4831.
57. Valberg PA, Kavet R, Rafferty CN. 1997. Can low-level 50/60-Hz electric and magnetic fields cause biological effects? Radia Res 148:2-21.
58. Vaughan TE, Weaver JC. 1998. Molecular change due to biomagnetic stimulation and transient magnetic fields: mechanical interference constraints on possible effects by cell membrane pore creation via magnetic particles. Bioelectrochem Bioenerget 46:121-128.
59. Weaver JC. 2002. Understanding conditions for which biological effects of nonionizing electromagnetic fields can be expected. Bioelectrochemistry 56:207-209.
60. Weaver JC, Astumian RD. 1990. The response at cells to very weak electric fields: the thermal noise limit. Science 247:459-462.
61. Weaver JC, Vaughan TE, Astumian RD. 2000. Biological sensing of small field differences by magnetically sensitive chemical reactions. Nature 405:707-709.
62. Weaver JC, Vaughan TE, Martin GT. 1999. Biological effects due to weak electric and magnetic fields: the temperature variation threshold. Biophys J 76:3026-3030.
63. Wertheimer N, Leeper E. 1979. Electrical wiring configurations and childhood cancer. Am J Epidemiol 109:273-284.
64. Yasui M, Kikuchi T, Ogawa M, Otaka Y, Tsuchitani M, Iwata H. 1997. Carcinogenicity test of 50 Hz sinusoidal magnetic fields in rats. Bioelectromagnetics 18:531-540.
65. Zaffanella LE. 1993. Survey of Residential Magnetic Field Sources. EPRI Report TR-102759, Vols 1 and 2. Palo Alto, CA:Electric Power Research Institute.