Cardiovascular vagosympathetic activity in rats with ventromedial hypothalamic obesity

Obesity Research

Volumn 11, Issue 1, 2003, Pages 54-64

  Valensi, Paul ^a,c   Doaré, Liliane ^b   Perret, Gérard ^a   Germack, Renée ^a   Pariès, Jacques ^a   Mesangeau, Didier ^b  

^a UNIVERSITÉ PARIS 13   (France)

^b LIPHA Research Laboratory   (France)

^c HÔPITAL JEAN VERDIER   (France)

Author keywords

Autonomic nervous system; Catecholamines; Hypertension; Insulin resistance; Ventromedial hypothalamic lesion

Indexed keywords

ANIMALIA;

ADRENALIN; ADRENERGIC RECEPTOR STIMULATING AGENT; ATROPINE; BETA ADRENERGIC RECEPTOR; CHOLINERGIC RECEPTOR BLOCKING AGENT; INSULIN; ISOPRENALINE; NITROPRUSSIDE SODIUM; NORADRENALIN;

ADRENERGIC SYSTEM; ANIMAL; ARTICLE; BLOOD; BLOOD PRESSURE; BODY WEIGHT; CARDIOVASCULAR SYSTEM; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HEART RATE; HEMODYNAMICS; HYPOTHALAMUS; INNERVATION; INSULIN RESISTANCE; OBESITY; PATHOPHYSIOLOGY; RAT; VAGUS NERVE; WISTAR RAT;

ANIMALS; ATROPINE; BLOOD GLUCOSE; BLOOD PRESSURE; BODY WEIGHT; CARDIOVASCULAR SYSTEM; EPINEPHRINE; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HEART RATE; HEMODYNAMIC PROCESSES; HYPOTHALAMUS, MIDDLE; INSULIN; INSULIN RESISTANCE; ISOPROTERENOL; NITROPRUSSIDE; NOREPINEPHRINE; OBESITY; PARASYMPATHOLYTICS; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA; SYMPATHETIC NERVOUS SYSTEM; SYMPATHOMIMETICS; VAGUS NERVE;

EID: 0037735420     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2003.10     Document Type: Article

References (56)

1. Reaven GM, H. Lithell H, Landsberg L. Hypertension and associated metabolic abnormalities. The role of insulin resistance and the sympathoadrenal system. N Engl J Med. 1996;334:374-81.
2. Landsberg L. Diet, obesity and hypertension: a hypothesis involving insulin, the sympathetic nervous system and adaptive thermogenesis. QJM. 1986;236:1081-90.
3. Reaven GM. Insulin resistance, hyperinsulinemia, and hypertriglyceridemia in the etiology and clinical course of hypertension. Am J Med. 1991;90(Suppl 2A):7S-12S.
4. Rupp H, Maisch B. Radiotelemetric characterization of overweight-associated rises in blood pressure and heart rate. Am J Physiol. 1999;46:H1540-H5.
5. Bunag RD, Barringer DL. Obese Zucker rats, though still normotensive, already have impaired chronotropic baroreflexes. Clin Exp Hypertens Part A Theory Pract. 1988;10(Suppl 1):257-62.
6. Pawloski CM, Kanagy NL, Mortensen LH, Fink GD. Obese Zucker rats are normotensive on normal and increased sodium intake. Hypertension. 1992;19(Suppl 1):I90-I5.
7. Hirsch JR, Leibel L, Mackintosh R, Augirre A. Heart rate variability as a measure of autonomic function during weight change in humans. Am J Physiol. 1991;261:R1418-R23.
8. Peterson HR, Rothschild M, Weinberg CR, Fell RD, McLeish KR, Pfeifer MA. Body fat and the activity of the autonomic nervous system. N Engl J Med. 1988;318:1077-83.
9. Rossi M, Marti G, Ricordi L, et al. Cardiac autonomic dysfunction in obese subjects. Clin Sci. 1989;76:567-72.
10. Valensi P, Phan Thi BN, Lormeau B, Pariès J, Attali JR. Cardiac autonomic function in obese patients. Int J Obes Relat Metab Disord. 1995;19:113-8.
11. Bunag RD, Eriksson L, Krizsan D. Baroreceptor reflex impairment and mild hypertension in rats with dietary-induced obesity. Hypertension. 1990;15:397-406.
12. Hall JE, Brands MW, Dixon WN, Smith MJ. Obesity-induced hypertension. Renal function and system hemodynamics. Hypertension. 1993;22:292-9.
13. Mizelle LH, Edwards TC, Montani JP. Abnormal cardiovascular responses to exercise during the development of obesity in dogs. Am J Hypertens. 1994;7:374-8.
14. Rocchini AP. Cardiovascular regulation in obesity-induced hypertension. Hypertension. 1992;19(Suppl 1):I56-I60.
15. Anderson EA, Hoffman RP, Balon TW, Sinkey CA, Mark AL. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest. 1991;87:2246-52.
16. Berne C, Fagius J, Pollare T, Hjemdahl P. The sympathetic response to euglycaemic hyperinsulinaemia. Diabetologia. 1992;35:873-9.
17. Liang CS, Doherty JU, Faillace R, et al. Insulin infusion in conscious dogs. J Clin Invest. 1982;69:1321-36.
18. Bray GA, Campfield LA. Metabolic factors in the control of energy stores. Metabolism. 1975;24:99-117.
19. Bray GA, Sclafani A, Novin D. Obesity-inducing hypothalamic knife cuts: effects on lipolysis and blood insulin levels. Am J Physiol. 1982;23:R445-R9.
20. Jeanrenaud B. Insulin, corticosterone and the autonomic nervous system in animal obesities: a viewpoint. Diabetologia. 1995;38:998-1002.
21. Inoue S, Satoh S, Saito M, Naitoh M, Suzuki H, Egawa M. Effects of selective vagotomy on circadian rhythms of plasma glucose, insulin and food intake in control and ventromedial hypothalamic (VMH) lesioned rats. Obes Res. 1995;3(Suppl 5):747S-52S.
22. Penicaud L, Larue-Aghagiotis C, Le Magnen J. Endocrine basis for weight gain after fasting or VMH lesion in rats. Am J Physiol. 1983;245:E246-E52.
23. Brockway BP, Mills PA, Azar SH. A new method for continuous chronic measurement and recording of blood pressure, heart rate and activity in the rat via radio-telemetry. Clin Exp Hypertens. 1991;A13:885-95.
24. Ferré P, Leturque A, Burnol A-F, Pénicaud L, Girard J. A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anesthetized rat. Biochem J. 1985;228:103-10.
25. Germack R, Starzec A, Vassy R, Perret G. Beta-adrenoceptor subtype expression and function in rat white adipocytes. Br J Pharmacol. 1997;120:201-10.
26. Yoshimatsu H, Niijima A, Oomura Y, Kamabe K, Katafuchi T. Effects of hypothalamic lesion on pancreatic autonomic nerve activity in the rat. Brain Res. 1984;303:147-52.
27. Bray GA. Autonomic and endocrine factors in the regulation of energy balance. Fed Proc. 1986;45:1404-10.
28. Lopaschuk GD. Abnormal mechanical function in diabetes: relationship to altered myocardial carbohydrate/lipid metabolism. Coron Art Dis. 1996;7:116-23.
29. Vettor R, Fabris R, Serra R, et al. Changes in FAT/CD36, UCP2, UCP3 and GLUT4 gene expression during lipid infusion in rat skeletal and heart muscle. Int J Obes Relat Metab Disord. 2002;26:838-47.
30. Brands MW, Hildebrandt DA, Mizelle HL, Hall JE. Sustained hyperinsulinemia increases arterial pressure in conscious rats. Am J Physiol. 1991;260:R764-R8.
31. Edwards JG, Tipton CM. Influences of exogenous insulin on arterial pressure measurements of the rat. J Appl Physiol. 1989;67:2335-42.
32. Meehan WP, Buchanan TA, Hsueh W. Chronic insulin administration elevates blood pressure in rats. Hypertension. 1994;23:1012-7.
33. Qadir E, Porter JP. Effect of insulin on regional vascular resistances in conscious rats. Am J Physiol. 1996;:R450-R5.
34. Brands MW, Mizelle HL, Gaillard CA, Hildebrandt DA, Hall JE. The hemodynamic response to chronic hyperinsulinemia in conscious dogs. Am J Hypertens. 1991;4:164-8.
35. Bunag RD, Krizsan D, Itoh H. Sympathetic activation by chronic insulin treatment in conscious rats. J Pharmacol Exp Ther. 1991;259:131-8.
36. Huang W, Hsieh P, Jin J. Chronic hyperinsulinemia induces hypertension in rats. Genet Hypertens. 1992;218:77-9.
37. Brands MW, Garrity CN, Holman MG, Hall JE. Exaggerated pressor and chronotropic response to chronic hyperinsulinemia in SHR versus WKY rats (abstract). FASEB J. 1993;7:A6.
38. Tomiyama H, Kushiro T, Abeta H, et al. Blood pressure response to hyperinsulinemia in salt-sensitive and salt-resistant rats. Hypertension. 1992;20:596-600.
39. Koopmans SJ, Ohman L, Haywood JR, Mandarino LJ, De Fronzo RA. Seven days of euglycemic hyperinsulinemia induces insulin resistance for glucose metabolism but not hypertension, elevated catecholamine levels, or increased sodium retention in conscious normal rats. Diabetes. 1997;46:1572-8.
40. Inoue S, Bray GA. The effect of subdiaphragmatic vagotomy in rats with ventromedial hypothalamic obesity. Endocrinology. 1977;100:108-14.
41. Berthoud HR, Jeanrenaud B. Acute hyperinsulinemia and its reversal by vagotomy following lesions of the ventromedial hypothalamus in anesthetized rats. Endocrinology. 1979;105:146-51.
42. Bray GA, York DA. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol Rev. 1979;59:719-809.
43. Shimazu T. Central nervous system regulation of liver and adipose tissue metabolism. Diabetologia. 1981;20:343-56.
44. Young JB, Landsberg L. Stimulation of the sympathetic nervous system during sucrose feeding. Nature. 1977;269:615-7.
45. Bray GA, Nishizawa Y. Ventromedial hypothalamus modulates fat mobilization during fasting. Nature. 1978;27:900-2.
46. Vander Tuig JG, Knehans AW, Romsos DR. Reduced sympathetic nervous system activity in rats with ventromedial hypothalamic lesions. Life Sci. 1982;30:913-20.
47. Niijima A, Rohner-Jeanrenaud F, Jeanrenaud B. Electrophysiological studies on the role of the ventromedial hypothalamus on the sympathetic efferent nerve activity of brown adipose tissue in the rat. Am J Physiol. 1984;247:R650-R4.
48. Okada M, Bunag RD. Insulin acts centrally to enhance reflex tachycardia in conscious rats. Am J Physiol. 1994;266:R481-R6.
49. Hall JE, Brands MW, Kivlighn SD, Mizelle L, Heldbrandt DA, Gaillard CA. Chronic hyperinsulinemia and blood pressure; interaction with catecholamines? Hypertension. 1990;15:519-27.
50. Tanabe S, Bunag RD. Aging escalates baroreceptor reflex suppression by the posterior hypothalamus in rats. Hypertension. 1991;17:80-90.
51. Pénicaud L, Ferré P, Kande J, Leturque A, Issad T, Girard J. Effect of anesthesia on glucose production and utilization in rats. Am J Physiol. 1987;252:E365-E9.
52. Silbergeld S, Kvetnansky R, Weise VK, Kopin IJ. Effect of repeated administration of 2-deoxy-D-glucose or insulin on catecholamine-synthesizing enzymes in rat adrenals. Biochem Pharmacol. 1971;20:1763-8.
53. Gripois D, Valens M. Adrenal phenylethanolamine-N-methyltransferase activity in the young rat: influence of thyroid hormones and insulin-induced hypoglycemia. Biol Neonate. 1986;49:219-23.
54. Bhagat B, Burke WJ, Davis JW. Effect of reserpine on the activity of adrenal enzymes involved in the synthesis of adrenaline. Br J Pharmacol. 1971;43:819-27.
55. Kvetnansky R, Weise VK, Kopin IJ. Elevation of adrenal tyrosine hydroxylase and phenyl-ethanolamine-N-methyltransferase by repeated immobilization of rats. Endocrinology. 1970;87:744-9.
56. Laakso M, Edelman SV, Brechtel G, Baron AD. Decreased effect of insulin to stimulate muscle blood flow in obese man. A novel mechanism for insulin resistance. J Clin Invest. 1990;85:1844-52.