Thr-431 and Arg-433 are part of a conserved sequence motif of the glutamine amidotransferase domain of CTP synthases and are involved in GTP activation of the Lactococcus lactis enzyme

Journal of Biological Chemistry

Volumn 278, Issue 11, 2003, Pages 9407-9411

  Willemoës, Martin ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; MUTAGENESIS; MUTAGENS;

ACTIVATION CONSTANT;

ENZYMES;

ADENOSINE TRIPHOSPHATE; AMMONIUM CHLORIDE; ARGININE; BACTERIAL ENZYME; CYTIDINE TRIPHOSPHATE SYNTHASE; GLUTAMINASE; GLUTAMINE; GLUTAMINE AMIDOTRANSFERASE; GUANOSINE TRIPHOSPHATE; METHIONINE; MUTANT PROTEIN; PROTEIN R433M; PROTEIN T43V; SYNTHETASE; THREONINE; TRANSFERASE; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE; VALINE; ANTHRANILATE SYNTHASE; ANTHRANILATE SYNTHASE, GLUTAMINE AMIDOTRANSFERASE SUBUNIT; DNA; LIGASE;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SUBSTRATE; ENZYME SYNTHESIS; LACTOCOCCUS LACTIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; WILD TYPE; BINDING SITE; CHEMISTRY; DOSE RESPONSE; ENZYMOLOGY; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); LACTOCOCCUS LACTIS; POSIBACTERIA; STREPTOCOCCUS;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC SITE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMMONIUM CHLORIDE; ANTHRANILATE SYNTHASE; ARGININE; CARBON-NITROGEN LIGASES; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; GLUTAMINASE; GUANOSINE TRIPHOSPHATE; KINETICS; LACTOCOCCUS LACTIS; METHIONINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NITROGENOUS GROUP TRANSFERASES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; THREONINE; VALINE;

EID: 0037715142     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212995200     Document Type: Article

References (25)

1. von der Saal, W., Anderson, P. M., and Villafranca, J. J. (1985) J. Biol. Chem. 260, 14993-14997
2. Lewis, D. A., and Villafranca, J. J. (1989) Biochemistry 28, 8454-8459
3. Wadskov-Hansen, S. L., Willemoes, M., Martinussen, J., Hammer, K., Neuhard, J., and Larsen, S. (2001) J. Biol. Chem. 276, 38002-38009
4. Levitzki, A., and Koshland, D. E., Jr. (1972) Biochemistry 11, 241-246
5. Weng, M., Makaroff, C. A., and Zalkin, H. (1986) J. Biol. Chem. 261, 5568-5574
6. Bearne, S. L., Hekmat, O., and Macdonnell, J. E. (2001) Biochem. J. 356, 223-232
7. Chittur, S. V., Klem, T. J., Shafer, C. M., and Davisson, V. J. (2001) Biochemistry 40, 876-887
8. Zalkin, H., and Smith, J. L. (1998) Adv. Enzymol. Relat. Areas Mol. Biol. 72, 87-144
9. Wylie, J. L., Wang, L. L., Tipples, G., and McClarty, G. (1996) J. Biol. Chem. 271, 15393-15400
10. Whelan, J., Phear, G., Yamauchi, M., and Meuth, M. (1993) Nat. Genet. 3, 317-322
11. Ostrander, D. B., O'Brien, D. J., Gorman, J. A., and Carman, G. M. (1998) J. Biol. Chem. 273, 18992-19001
12. Weng, M. L., and Zalkin, H. (1987) J. Bacteriol. 169, 3023-3028
13. Iyengar, A., and Bearne, S. L. (2003) Biochem. J. 369, 497-507
14. Willemoes, M., and Sigurskjold, B. W. (2002) Eur. J. Biochem. 269, 4772-4779
15. Levitzki, A., Stallcup, W. B., and Koshland, D. E., Jr. (1971) Biochemistry 10, 3371-3378
16. Levitzki, A., and Koshland, D. E., Jr. (1972) Biochemistry 11, 247-253
17. Long, C. W., Levitzki, A., and Koshland, D. E., Jr. (1970) J. Biol. Chem. 245, 80-87
18. Pappas, A., Yang, W. L., Park, T. S., and Carman, G. M. (1998) J. Biol. Chem. 273, 15954-15960
19. Yang, W. L., McDonough, V. M., Ozier-Kalogeropoulos, O., Adeline, M. T., Flocco, M. T., and Carman, G. M. (1994) Biochemistry 33, 10785-10793
20. Thomas, P. E., Lamb, B. J., and Chu, E. H. (1988) Biochim. Biophys. Acta 953, 334-344
21. van Kuilenburg, A. B., Elzinga, L., van den Berg, A. A., Slingerland, R. J., and Van Gennip, A. H. (1994) Anticancer Res. 14, 411-415
22. Anderson, P. M. (1983) Biochemistry 22, 3285-3292
23. Robertson, J. G. (1995) Biochemistry 34, 7533-7541
24. Laemmli, U. K. (1970) Nature 227, 680-685
25. Long, C. W., and Pardee, A. B. (1967) J. Biol. Chem. 242, 4715-4721