Standard gentamicin dosage regimen in neonates

American Journal of Health-System Pharmacy

Volumn 56, Issue 5, 1999, Pages 440-443

  Langlass, Theresa M ^a,b   Mickle, Tim R ^a  

^a McAllen Medical Center   (United States)

^b McAllen Medical Center   (United States)

Author keywords

Aminoglycosides; Dosage; Dosage schedules; Gentamicin sulfate; Pediatrics; Pharmacokinetics; Protocols

Indexed keywords

ANTIINFECTIVE AGENT; GENTAMICIN;

ARTICLE; BLOOD; DRUG ADMINISTRATION; FEMALE; HUMAN; MALE; METABOLISM; NEWBORN;

ANTI-BACTERIAL AGENTS; DRUG ADMINISTRATION SCHEDULE; FEMALE; GENTAMICINS; HUMANS; INFANT, NEWBORN; MALE;

EID: 0033094597     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajhp/56.5.440     Document Type: Article

References (14)

1. Nicolau DP, Freeman CD, Belliveau PP et al. Experience with a once-daily aminoglycoside program administered to 2,184 adult patients. Antimicrob Agents Chemother. 1995; 39:650-5.
2. Hatala R, Dinh T, Cook DJ. Once-daily aminoglycoside dosing in immunocompetent adults: a meta-analysis. Ann Intern Med. 1996; 124:717-25.
3. Maller R, Ahrne E, Eilard T et al. Efficacy and safety of amikacin in system infections when given as a single daily dose or in two divided doses. J Antimicrob Chemother. 1991; 27(suppl C):121-8.
4. Nordstrom L, Ringberg H, Cronberg S et al. Does administration of an aminoglycoside in a single daily dose affect its efficacy and toxicity? J Antimicrob Chemother. 1990; 25:159-73.
5. Lopez-Samblas A, Diaz P, Bunion K. Drug dosing in the neonate. In: Murphy JE, ed. Clinical pharmacokinetics pocket reference. Bethesda, MD: American Society of Hospital Pharmacists; 1993:321-39.
6. Skopnik H, Heimann G. Once daily aminoglycoside dosing in full term neonates. Pediatr Infect Dis J. 1995; 14(1):71-2.
7. Capers CC, Gregory DF, Herzog CC. Optimal gentamicin dosing in neonates. Ann Pharmacother. 1995; 29:430-1. Letter.
8. Murphy JE, Carter JT. Evaluation of gentamicin therapy in newborns at a community hospital and development of simple dosing guidelines. Hosp Pharm. 1996; 31:1283-9.
9. Hayani KC, Hatzopoulos FK, Frank AL et al. Pharmacokinetics of once-daily dosing of gentamicin in neonates. J Pediatr. 1997; 131:76-80.
10. Young TE. Neofax '96. 9th ed. Raleigh, NC: Acorn; 1996.
11. Shargel L, Yu ABC. Applied biopharmaceutics and pharmacokinetics. 3rd ed. Norwalk, CT: Appleton & Lange; 1993:47-59.
12. Sawchuck RJ, Zaske DE, Cipolle RJ et al. Kinetic model for gentamicin dosing with the use of individual patient parameters. Clin Pharmacol Ther. 1977; 21:362-9.
13. Moore RD, Smith CR, Lietman PS et al. The association of aminoglycoside plasma levels with mortality in patients with gram-negative bacteremia. J Infect Dis. 1984; 9:443-8.
14. Noone P, Parsons TMC, Pattison JR et al. Experience in monitoring gentamicin therapy during treatment of serious gram-negative sepsis. Br Med J. 1974; 1:447-81.