Induction of clinical remission in T-large granular lymphocyte leukemia with cyclosporin A, monitored by use of immunophenotyping with Vβ antibodies

Leukemia

Volumn 12, Issue 2, 1998, Pages 150-154

  Brinkman, K ^a   Van Dongen, J J M ^b   Van Lom, K ^b   Groeneveld, K ^b   Misere J F M M ^a   Van der Heul, C ^a  

^a Microvida Laboratory for Medical Microbiology and Immunology   (Netherlands)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

Cyclosporin A; Evans' syndrome; Leukemia; T LGL leukemia; TCR genes; V antibodies

Indexed keywords

CD3 ANTIGEN; CD8 ANTIGEN; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; PREDNISONE; RECEPTOR ANTIBODY; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ADULT; ANEMIA; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNE HEMOLYTIC ANEMIA; CASE REPORT; CONTROLLED STUDY; DOSE CALCULATION; FEMALE; GENE REARRANGEMENT; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOPHENOTYPING; LARGE GRANULAR LYMPHOCYTE; LEUKEMIA REMISSION; LYMPHATIC LEUKEMIA; LYMPHOCYTOSIS; NEUTROPENIA; PRIORITY JOURNAL; SPLENECTOMY; T CELL LEUKEMIA; T LYMPHOCYTE RECEPTOR GENE; THROMBOCYTOPENIA; TREATMENT FAILURE;

EID: 0031908457     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400907     Document Type: Article

References (16)

1. Brouet JC, Flandrin G, Sasportes M, Preud'Homme J-L, Seligmann M. Chronic lymphocytic leukemia of T-cell origin: immunological and clinical evaluation in eleven patients. Lancet 1975; 2: 890-893.
2. Bom van Noorloos AA, Pegels HG, van Oers RHJ, Silverbusch J, Feltkamp-Vroom TM, Goudsmit R, Zeijlemaker WP, von dem Borne AEGK, Melief CJM. Proliferation of T-gamma cells with killer-cell activity in two patients with neutropenia and recurrent infections. New Engl J Med 1980; 302: 933-937.
3. Loughran Jr TP, Kadin ME, Starkebaum G, Abkowitz JL, Clark EA, Disteche C, Lum LG, Slichter SJ. Leukemia of large granular lymphocytes: association with clonal chromosomal abnormalities and autoimmune neutropenia, thrombocytopenia, and hemolytic anemia. Ann Intern Med 1985; 102: 169-175.
4. Bennett JM, Juliusson G, Mecucci C. Morphologic, immunologic, and cytogenetic classification of the chronic (mature) B and T lymphoid leukemias: fourth meeting of the MIC Cooperative Study Group. Cancer Res 1990; 50: 2212.
5. Loughran Jr TP. Clonal diseases of large granular lymphocytes. Blood 1993; 82: 1-14.
6. Pandolfi F, Loughran Jr TP, Starkebaum G, Chisesi T, Barbui T, Chan WC, Brouet JC, de Rossi G, McKenna RW, Salsano F, Herrmann F, van Oostveen JWD, Schlimok G, Cafaro A, Zambello R, Garcia Rodriguez MC, Geisler CH, Pizollo G, Steis RG, Brisbane JU, Kadin ME, Mantovani A, Tagawa S, Fauci AS, Gastl G, Palutke M, Proctor SJ, Pross HF, Mancini P, Aiutu F, Semenzato G. Clinical course and prognosis of the lymphoproliferative disease of granular lymphocytes - a multicenter study. Cancer 1990; 65: 341-348.
7. van Dongen JJM, Adriaansen HJ, Hooijkaas H. Immunophenotyping of leukemias and non-Hodgkin's lymphomas: immunological markers and their CD codes. Neth J Med 1988; 33: 298-314.
8. Groeneveld K, Comans-Bitter WM, van den Beemd MWM, Wolvers-Tettero ILM, de Groot R, Neijens HJ, Hooijkaas H, van Dongen JJM. Blood T cell subsets in health and disease. J Int Fed Clin Chem 1994; 6: 84-94.
9. van Dongen JJM, van den Beemd MWM, Schellekens M, Wolvers-Tettero ILM, Langerak AW, Groeneveld K. Analysis of malignant T cells with the Vβ antibody panel. The Immunologist 1996; 4: 37-40.
10. van Dongen JJM, Wolvers-Tettero ILM. Analysis of immunoglobulin and T cell receptor genes. Part I: basic and technical aspects. Clin Chim Acta 1991; 198: 1-91.
11. Evans RS, Duane RT. Acquired hemolytic anemia: I. The relation of erythrocyte antibody production to activity of the disease. II. The significance of thrombocytopenia and leukopenia. Blood 1949; 4: 1196-1213.
12. Garipidou V, Tsatalas C, Sinacos Z. Severe neutropenia in a patient with granular lymphocytosis: prolonged successful control with cyclosporin A. Hematologica 1991; 76: 424-425.
13. Selleri C, Catalano L, Allinito F, De Rosa G, Vaglio S, Rotoli B. Cyclosporin A in adult-onset cyclic neutropenia. Br J Haematol 1988; 68: 137-138.
14. Pastor E, Sayas MJ. Severe neutropenia associated with large granular lymphocyte lymphocytosis; successful control with cyclosporin A. Blut 1989; 59: 501-502.
15. Jakubowski A, Winton EF, Gencarelli A, Gabrilove J. Treatment of chronic neutropenia associated with large granular lymphocytosis with cyclosporin A and filgrastim. Am J Hematol 1995; 50: 288-291.
16. Loughran Jr TP, Kidd PC, Starkebaum G. Treatment of large granular lymphocyte leukemia with oral low-dose methotrexate. Blood 1994; 84: 2164-2170.