Comparative actions of diazepam and other phosphodiesterase inhibitors on the effects of noradrenaline in rat myocardium

Pharmacology and Toxicology

Volumn 93, Issue 1, 2003, Pages 23-28

  Juan Fita, María J ^a   Vargas, María L ^a   Hernández, Jesús ^a  

^a UNIVERSITY OF MURCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

8 METHOXYMETHYL 3 ISOBUTYL 1 METHYLXANTHINE; 9 (2 HYDROXY 3 NONYL)ADENINE; CORTICOSTERONE; DESIPRAMINE; DIAZEPAM; DIMETHYL SULFOXIDE; MILRINONE; NORADRENALIN; PHENTOLAMINE; PHOSPHODIESTERASE 1 INHIBITOR; PHOSPHODIESTERASE 2 INHIBITOR; PHOSPHODIESTERASE I; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATECHOLAMINE RELEASE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENTIATION; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBUNIT; FEMALE; HEART MUSCLE; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE; INOTROPISM; MALE; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; RAT;

ADENINE; ANIMALS; CYCLIC AMP; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FEMALE; ISOENZYMES; MALE; MILRINONE; MYOCARDIAL CONTRACTION; NOREPINEPHRINE; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; ROLIPRAM; XANTHINES;

ANIMALIA;

EID: 0037669365     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0773.2003.930103.x     Document Type: Article

References (16)

1. Beavo, J. A.: Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms. Physiol. Rev. 1995, 75, 725-748.
2. Collado, C., J. Beleta, E. Martínez, M. Miralpeix, T. Domenech, J.M. Palacios & J. Hernández: Functional and biochemical evidence for diazepam as cyclic nucleotide phosphodiesterase type 4 inhibitor. Brit. J. Pharmacol. 1998, 123, 1047-1054.
3. Cosentino, M., F. Marino, S. Cattaneo, L. Di Grazia, C. Francioli, A. M. Fietta, S. Lecchini & G. Frigo: Diazepam-binding inhibitor-derived peptides induce intracellular calcium changes and modulate human neutrophil function. J. Leukoc. Biol. 2000, 67, 637-643.
4. Elgoyhen, B. & E. Adler-Graschinsky: Diminution by benzodiazepines of the chronotropic responses to noradrenaline in rat isolated atria. Eur. J. Pharmacol. 1989, 164, 467-478.
5. Galindo, A., M. L. Vargas, J. García-Stañ, T. Fuentes & J. Hernández: Synergistic interaction of diazepam with 3′,5′-cyelic adenosine monophosphate-elevating agents on rat aortic rings. Eur. J. Pharmacol. 2001, 428, 269-275.
6. Gristwood, R.W., J. Beleta, J. Bou, I. Cardelús, A.G. Fernández, J. Llenas & P. Berga: Studies on the cardiac actions of flosequinan in vitro. Brit. J. Pharmacol. 1992, 105, 985-991.
7. Hara, Y., H. Kaigo, Y. Minami, H. Watanabe, H. Gomi, H. Nishimura, A. Chagun & H. Kondo: Diazepam potentiates the positive inotropic effects of histamine and forskolin in guinea-pig papillary muscles. J. Vet. Pharmacol. Therap. 1998, 21, 375-379.
8. Katano, Y. & M. Endoh: Differential effects of Ro 20-1724 and isobutylmethylxanthine on the basal force of contraction and β-adrenoceptor-mediated response in the rat ventricular myocardium. Biochem. Biophys. Res. Commun. 1990, 167, 123-129.
9. Katano, Y. & M. Endoh: Effects of a cardiotonic quinolinone derivative Y-20487 on the isoproterenol-induced positive inotropic action and cyclic AMP accumulation in rat ventricular myocardium: Comparison with rolipram, Ro 20-1724, milrinone and isobutylmethylxantine. J. Cardiovasc. Pharmacol. 1992, 20, 715-722.
10. Kelso, E. K., B.J. McDermott & B. Silke: Cardiotonic actions of selective phosphodiesterase inhibitors in rat isolated ventricular cardiomyocytes. Brit. J. Pharmacol. 1993, 110, 1387-1394.
11. Marín, J. & J. Hernández: Diazepam potentiates the effects of endogenous catecholamines on contractility and cyclic AMP levels in rat ventricular myocardium. Naunyn-Schmiedebergs Archiv. Pharmacol. 2002, 365, 260-268.
12. Martínez, E., R. Peñafiel, C. Collado & J. Hernández: Diazepam potentiates the positive inotropic effect of isoprenaline in rat ventricle strips: role of cyclic AMP. Eur. J. Pharmacol. 1995, 282, 169-175.
13. Nicholson, C.D., R.A.J. Challiss & M. Shahid: Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. Trends Pharmacol. Sci. 1991, 12, 19-27.
14. Scholz, H.: Effects of beta- and alpha-adrenoceptor activators and adrenergic transmitter releasing agents on the mechanical activity of the heart. In: Adrenergic activators and inhibitors. Ed.: L. Szekeres. Springer-Verlag, Berlin, 1980, pp. 651-733.
15. Vargas, M. L., C. Abella & J. Hernández: Diazepam increases the hypothalamic-pituitary-adrenocortical (HPA) axis activity by a cyclic AMP-dependent mechanism. Brit. J. Pharmacol. 2001, 133, 1355-1361.
16. Verde, I., G. Vandecasteele, F. Lezoualc'h & R. Fischmeister: Characterization of the cyclic nucleotide phosphodiesterase subtypes involved in the regulation of the L-type Ca 2+ current in rat ventricular myocytes. Br. J. Pharmacol. 1999, 127, 65-74.