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Anhydrous HF has proven to be a useful reagent for the final side chain deprotection in the synthesis of peptide libraries (Lebl et al. J. Comb. Chem. 1999, 1 (6), 474-479). TFMSA acid has also been successfully applied as an alternative reagent for this purpose (Bourne et al. J. Org. Chem. 2001, 66, 7706-7713).
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Anhydrous HF has proven to be a useful reagent for the final side chain deprotection in the synthesis of peptide libraries (Lebl et al. J. Comb. Chem. 1999, 1 (6), 474-479). TFMSA acid has also been successfully applied as an alternative reagent for this purpose (Bourne et al. J. Org. Chem. 2001, 66, 7706-7713).
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Quantitative amino acid analysis of an Ac-Phe-HMFS-PEGA resin model before and after the treatment proved that the amino acid loss was less than 5%
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Quantitative amino acid analysis of an Ac-Phe-HMFS-PEGA resin model before and after the treatment proved that the amino acid loss was less than 5%.
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17
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19
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0442265228
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note
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2+ = 1176.2 m/z (calcd 1176.1 m/z).
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20
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0033683359
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For review of linkers used in solid-phase organic chemistry, see: Guillier, F.; Drain, D.; Bradley, M. Chem. Rev. 2000, 100, 2091-2157.
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