Normalization of high interictal interietal cerebrovascular reactivity in migraine without aura by treatment with flunarizine

Headache

Volumn 43, Issue 5, 2003, Pages 464-469

  Dora, Babür ^a,b   Balkan, Sevin ^a   Tercan, Evren ^a  

^a AKDENIZ UNIVERSITY   (Turkey)

^b NONE   (Turkey)

Author keywords

Breath holding index; Cerebrovascular reactivity; Flunarizine; Migraine without aura; Transcranial Doppler ultrasound

Indexed keywords

FLUNARIZINE;

ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD FLOW VELOCITY; BLOOD VESSEL REACTIVITY; BRAIN BLOOD VESSEL; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLE; DOPPLER ECHOGRAPHY; DRUG MECHANISM; FEMALE; HEADACHE; HUMAN; HYPERCAPNIA; MALE; MIGRAINE; PRIORITY JOURNAL; SYSTOLE; TREATMENT OUTCOME; VASODILATATION;

ADULT; CALCIUM CHANNEL BLOCKERS; CEREBROVASCULAR CIRCULATION; FEMALE; FLUNARIZINE; HUMANS; MALE; MIGRAINE WITHOUT AURA;

EID: 0037651343     PISSN: 00178748     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1526-4610.2003.03091.x     Document Type: Article

References (38)

1. Silvestrini M, Cupini LM, Troisi E, Matteis M, Bernardi G. Estimation of cerebrovascular reactivity in migraine without aura. Stroke. 1995;26:81-83.
2. Fiermonte G, Annulli A, Pierelli F. Transcranial Doppler evaluation of cerebral hemodynamics in migraineurs during prophylactic treatment with flunarizine. Cephalalgia. 1999;19:492-496.
3. Thie A, Spitzer K, Lachenmayer L, Kunze K. Prolonged vasospasm in migraine detected by noninvasive transcranial Doppler ultrasound. Headache. 1988;28:183-186.
4. Fiermonte G, Giecomini P, Sanarelli L. Transcranial Doppler sonography in patients with migraine and cluster headache. In: Abstracts of the First International Conference on Transcranial Doppler Sonography, 1986, Rome, Italy.
5. Totaro R, De Matteis G, Marini C, Prencipe M. Cerebral blood flow in migraine with aura: a transcranial Doppler sonography study. Headache. 1992;32:446-451.
6. Zwetsloot CP, Caekebeke JF, Jansen JC, Odink J, Ferrari MD. Blood flow changes in migraine attacks - A transcranial Doppler study. Cephalalgia. 1991;11:103-107.
7. De Benedittis G, Da Passano CF, Granata G, Lorenzetti A. CBF changes during headache-free periods and spontaneous/induced attacks in migraine with and without aura: a TCD and SPECT comparison study. J Neurosurg Sci. 1999;43:141-147.
8. Lauritzen M, Olesen J. Regional cerebral blood flow during migraine attacks by Xenon-133 inhalation and emission tomography. Brain. 1984;107:447-461.
9. Harer C, von Kummer R. Cerebrovascular CO2 reactivity in migraine: assessment by transcranial Doppler ultrasound. J Neurol. 1991;238:23-26.
10. Skyhij Olsen T, Lassen NA. Blood flow and vascular reactivity during attacks of classic migraine: limitations of the Xe-133 intraarterial technique. Headache. 1988;29:15-20.
11. Totaro R, Marini C, De Matteis G, Di Napoli M, Carolei A. Cerebrovascular reactivity in migraine during headache-free intervals. Cephalalgia. 1997;17: 191-194.
12. Thomas DT, Harpold GJ, Troost BT. Cerebrovascular reactivity in migraineurs as measured by transcranial Doppler. Cephalalgia. 1990;10:95-99.
13. Silvestrini M, Matteis M, Troisi E, Cupini LM, Bernardi G. Cerebrovascular reactivity in migraine with and without aura. Headache. 1996;36:37-40.
14. Kastrup A, Thomas C, Hartmann C, Schabet M. No effect of prophylactic treatment with metoprolol on cerebrovascular CO2 reactivity in migraineurs. Cephalalgia. 1998;18:353-357.
15. Leone M, Grazzi L, La Mantia L, Bussone G. Flunarizine in migraine: a minireview. Headache. 1991;31: 388-391.
16. Van Nueten JM, De Clerck F. Vascular reactivity and calcium entry blockers. Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984;17:575-583.
17. Greenberg DA. Calcium channel antagonists and the treatment of migraine. Clin Neuropharmacol. 1986;9:311-328.
18. Wauquier A, Ashton D, Marannes R. The effects of flunarizine in experimental models related to the pathogenesis of migraine. Cephalalgia. 1985;5(suppl 2):119-123.
19. Wauquier A, Ashton D, Edmonds HL Jr. Protection against cerebral hypoxia by antimigraine drugs. In: Amery WK, Van Nueten JM, Wauquier A, eds. The Pharmacological Basis of Migraine Therapy. London: Pitman; 1984:134-148.
20. Wauquier A, Ashton D, Clincke G, Fransen J. "Calcium entry blockers" as cerebral protecting agents: comparative activity in tests of hypoxia and hyperexcitability. Jpn J Pharmacol. 1985;38:1-7.
21. Govoni S, Batteini F, Magnoni MS, Trabucchi M. Non-vascular central nervous system effects of calcium entry blockers. Cephalalgia. 1985;5(suppl 2): 115-118.
22. Marranes S, Wauquier A, Reid K, De Prins E. Effect of drugs on cortical spreading depression. In: Amery WK, Wauquier A, eds. The Prelude to the Migraine Attack. London: Bailliere Tindall; 1986:158-173.
23. Dora B, Balkan S. Exaggerated interictal cerebrovascular reactivity but normal blood flow velocities in migraine without aura. Cephalalgia. 2002;22: 288-290.
24. Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia. 1988;8(suppl 7):10-73.
25. Markus HS, Harrison MJ. Estimation of cerebrovascular reactivity using transcranial Doppler, including the use of breath-holding as the vasodilatory stimulus. Stroke. 1992;23:668-673.
26. Diener HC, Peters C, Rudzio M, et al. Ergotamine, flunarizine and sumatriptan do not change cerebral blood flow velocity in normal subjects and migraineurs. J Neurol. 1991;238:245-250.
27. Vanhoutee PM. Calcium entry blockers, vascular smooth muscle and systemic hypertension. Am J Cardiol. 1985;55:17B-23B.
28. Micheli FE, Pardal MM, Giannaula R, et al. Movement disorders and depression due to flunarizine and cinnarizine. Mov Disord. 1989;4:139-146.
29. Nyholt DR, Lea RA, Goadsby PJ, Brimage PJ, Griffiths LR. Familial typical migraine: linkage to chromosome 19p13 and evidence for genetic heterogeneity. Neurology. 1998;50:1428-1432.
30. May A, Ophoff RA, Terwindt GM, et al. Familial hemiplegic migraine locus on 19p13 is involved in the common forms of migraine with and without aura. Hum Genet. 1995;96:604-608.
31. Terwindt GM, Ophoff RA, van Eijk R, et al. Involvement of the CACNA1A gene containing region on 19p13 19pl3 in migraine with and without aura. Neurology. 2001;56:1028-1032.
32. Craig PJ, McAinsh AD, McCormack AL, et al. Distribution of the voltage -dependent calcium channel alpha 1A subunit throughout the mature rat brain and its relationship to neurotransmitter pathways. J Comp Neurol. 1998;397:251-267.
33. Stea A, Tomlinson WJ, Soong TW, et al. Localisation and functional properties of a rat brain alpha 1A calcium channel reflect similarities to neuronal Q- and P-type channels. Proc Natl Acad Sci U S A. 1994;91:10576-10580.
34. Asakura K, Kanemasa T, Minagawa K, et al. Alphaeudesmol, a P/Q-type Ca channel blocker, inhibits neurogenic vasodilatation and extravasation following electrical stimulation of trigeminal ganglion. Brain Res. 2000;873:94-101.
35. Sandor PS, Ambrosini A, Agosti RM, Scoenen J. Genetics of migraine: possible links to neurophysiological abnormalities. Headache. 2002;42:365-377.
36. Appel S, Kuritzky A, Zahavi I, Zigelman M, Akselrod S. Evidence for instability of the autonomic nervous system in patients with migraine headache. Headache. 1992;32:10-17.
37. Shechter A, Stewart WF, Silberstein SD, Lipton RB. Migraine and autonomic nervous system function: a population-based, case-control study. Neurology. 2002;58:422-427.
38. Zigelman M, Appel S, Davidovitch S, Kuritzky A, Zahavi I, Akselrod S. The effect of verapamil calcium antagonist on autonomic imbalance in migraine: evaluation by spectral analysis of beat-to-beat heart rate fluctuations. Headache. 1994;34:569-577.