Aldehyde dehydrogenase 2 genotypes, alcohol flushing symptoms and drinking patterns in Thai men1

Psychiatry Research

Volumn 118, Issue 1, 2003, Pages 9-17

  Assanangkornchai, Sawitri ^a   Noi Pha, Kusumarn ^a   Saunders, John B ^b   Ratanachaiyavong, Suvina ^a  

^a PRINCE OF SONGKLA UNIVERSITY   (Thailand)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Alcohol drinking; Aldehyde dehydrogenase; Flushing

Indexed keywords

ALDEHYDE DEHYDROGENASE;

ADULT; AGED; ALCOHOLISM; ALLELE; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DRINKING BEHAVIOR; FLUSHING; GENE FUNCTION; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MALE; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROBABILITY; QUESTIONNAIRE; STATISTICAL SIGNIFICANCE; THAILAND;

EID: 0037621686     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1781(03)00043-X     Document Type: Article

References (38)

1. Agarwal D.P., Harada S., Goedde H.W. Racial differences in biological sensitivity to ethanol: the role of alcohol dehydrogenase and aldehyde dehydrogenase isozymes. Alcoholism: Clinical and Experimental Research. 5:1981;12-16.
2. Assanangkornchai S., Geater A.F., Saunders J.B., McNeil D.R. Effects of paternal drinking, conduct disorder and childhood home environment on the development of alcohol use disorders in a Thai population. Addiction. 97:2002;217-226.
3. Assanangkornchai S., Saunders J.B., Conigrave K.M. Patterns of drinking in Thai men. Alcohol & Alcoholism. 35:2000;263-269.
4. Chao Y.C., Liou S.R., Chung Y.Y., Tang H.S., Hsu C.T., Li T.K., Yin S.J. Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients. Hepatology. 19:1994;360-366.
5. Chen W., Loh E., Hsu Y., Chen C., Yu J., Cheng A. Alcohol-metabolising genes and alcoholism among Taiwanese Han men: independent effect of ADH2, ADH3, and ALDH2. British Journal of Psychiatry. 168:1996;762-767.
6. Crabb D., Edenberg H., Bosron W., Li T. Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity: the inactive ALDH2-2 allele is dominant. Journal of Clinical Investigation. 83:1989;314-316.
7. Goedde H., Agarwal D. Polymorphism of aldehyde dehydrogenase and alcohol sensitivity. Enzyme. 37:1987;29-44.
8. Goedde H., Agarwal D., Harada S. Genetic studies on alcohol-metabolising enzymes: detection of isozymes in human hair roots. Enzyme. 25:1980;281-286.
9. Goedde H., Singh S., Agarwal D., Fritze G., Stapel K., Paik Y. Genotyping of mitochondrial aldehyde dehydrogenase in blood samples using allele-specific oligonucleotides: comparison with phenotyping in hair roots. Human Genetics. 81:1989;305-307.
10. Grant B., Harford T., Dawson D., Chou P., Pickering R. The Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS): reliability of alcohol and drug modules in a general population sample. Drug and Alcohol Dependence. 39:1995;37-44.
11. Harada S., Agarwal D., Goedde H. Aldehyde dehydrogenase deficiency as cause of flushing reaction to alcohol [in Japanese]. Lancet. 2:1981;982.
12. Harada S., Agarwal D., Goedde H., Tagaki S., Ishikawa B. Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency [in Japanese]. Lancet. 2:1982;827.
13. Higuchi S. Polymorphisms of ethanol metabolizing enzyme genes and alcoholism. Alcohol & Alcoholism Suppl. 2:1994;29-34.
14. Higuchi S., Muramatsu T., Shigemori K., Saito M., Kono H., Dufour M., Harford T. The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior [in Japanese]. Journal of Studies on Alcohol. 53:1992;170-175.
15. Higuchi S., Matsushita S., Muramatsu T., Murayama M., Hayashida M. Alcohol and aldehyde dehydrogenase genotypes and drinking behaviour [in Japanese]. Alcoholism: Clinical and Experimental Research. 20:1996;493-497.
16. Higuchi S., Parrish K., Dufour M., Towle L., Harford T. The relationship between three subtypes of the flushing response and DSM-III alcohol abuse in Japan. Journal of Studies on Alcohol. 53:1991;553-560.
17. Hsu L., Bendel R., Yoshida A. Direct detection of the usual and atypical alleles on the human aldehyde dehydrogenase-2 (ALDH2) locus. American Journal of Human Genetics. 41:1987;996-1001.
18. Johnson R., Nagoshi C., Schwitters S., Bowman K., Ahern F., Wilson J. Further investigation of racial/ethnic differences and of familial resemblances in flushing response to alcohol. Behavior Genetics. 14:1984;171-178.
19. Kunkel L., Smith K., Boyer S., Bogaonker D., Watchel S., Miller O., Breg W., Jones H.J., Rary J. Analysis of human Y chromosome-specific reiterated DNA in chromosome variants. Proceedings of the National Academy of Sciences of the United States of America. 74:1977;1245-1249.
20. Lee H.C., Lee H.S., Jung S.H., Yi S.Y., Jung H.K., Yoon J.H., Kim C.Y. Association between polymorphisms of ethanol-metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population. Journal of Korean Medical Science. 16:2001;745-750.
21. Luczak S.E., Wall T.L., Shea S.H., Byun S.M., Carr L.G. Binge drinking in Chinese, Korean, and White college students: genetic and ethnic group differences. Psychological Addictive Behaviour. 15:2001;306-309.
22. Muramatsu T., Wang Z., Fang Y., Hu K., Yan H., Yamada K., Higuchi S., Harada S., Kono H. Alcohol and aldehyde dehydrogenase genotypes and drinking behavior of Chinese living in Shanghai. Human Genetics. 96:1995;151-154.
23. Park J., Huang Y., Nagoshi C., Yuen S., Johnson R., Ching C., Bowman K. The flushing response to alcohol use among Koreans and Taiwanese. Journal of Studies on Alcohol. 45:1984;481-485.
24. Peng G.S., Wang M.F., Chen C.Y., Luu S.U., Chou H.C., Li T.K., Yin S.J. Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. Pharmacogenetics. 9:1999;463-476.
25. Saunders J.B. That's the limit: alcohol consumption and health. Medical Journal of Australia. 164:1996;133-134.
26. Saunders, J.B., Aasland, O., 1987. WHO Collaborative Project on Identification and Treatment of Persons with Harmful Alcohol Consumption: Report on phase 1, development of a screening instrument. World Health Organization, Division of Mental Health, Geneva.
27. Schmitz G., Walter T., Seibl R., Kessler C. Nonradioactive labeling of oligonucleotides in vitro with the hapten digoxigenin by tailing with terminal transferase. Annals of Biochemistry. 192:1991;222-231.
28. Schwitters, S.Y., Johnson, R.C., McClearn, G.E., Wilson J.R., 1982a. Alcohol use and the flushing response in different racial groups. Journal of Studies on Alcohol 43, 1259-1262.
29. Schwitters, S.Y., Johnson, R.C., Johnson, S.B., Ahern, F.M., 1982b. Familial resemblances in flushing following alcohol use. Behavior Genetics 12, 349-352.
30. Shen Y.C., Fan J.H., Edenberg H.J., Li T.K., Cui Y.H., Wang Y.F., Tian C.H., Zhou C.F., Zhou R.L., Wang J. Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism. Alcoholism: Clinical and Experimental Research. 21:1997;1272-1277.
31. Suwaki H., Ohara H. Alcohol-induced facial flushing and drinking behavior in Japanese men. Journal of Studies on Alcohol. 46:1985;196-198.
32. Takeshita T., Morimoto K., Mao X., Hashimoto T., Furuyama J. Characterization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population. Human Genetics. 94:1994;217-223.
33. Tanaka F., Shiratori Y., Yokosuka O., Imazeki F., Tsukada Y., Omata M. Polymorphism of alcohol-metabolizing genes affects drinking behavior and alcoholic liver disease in Japanese men. Alcoholism: Clinical and Experimental Research. 21:1997;596-601.
34. Thomasson H., Edenberg H., Crabb D., Mai X., Jerome R., Li T., Wang S., Lin Y., Lu R., Yin S. Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. American Journal of Human Genetics. 48:1991;677-681.
35. Ustun B., Compton W., Mager D., Babor T., Baiyewu O., Chatterji S., Cottler L., Gogus A., Mavreas V., Peters L., Pull C., Saunders J., Smeets R., Stipec M-R., Vrasti R., Hasin D., Room R., Van den Brink W., Regier D., Blaine J., Grant B.F., Sartorius N. WHO Study on the reliability and validity of the alcohol and drug use disorder instruments: overview of methods and results. Drug and Alcohol Dependence. 47:1997;161-169.
36. Wall T.L., Horn S.M., Johnson M.L., Smith T.L., Carr L.G. Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene. Journal of Studies on Alcohol. 61:2000;13-17.
37. Wall T.L., Shea S.H., Chan K.K., Carr L.G. A genetic association with the development of alcohol and other substance use behavior in Asian Americans. Journal of Abnormal Psychology. 110:2001;173-178.
38. Yoshida A., Hsu L., Yasunami M. Genetics of human alcohol-metabolizing enzymes. Progress in Nuclear Acid Research and Molecular Biology. 40:1991;255-287.