Hemoperfused isolated porcine slaughterhouse kidneys as a valid model for pharmacological studies

Journal of Pharmaceutical Sciences

Volumn 92, Issue 6, 2003, Pages 1147-1154

  Grosse Siestrup, Christian ^a   Unger, Volker ^a   Meissler, Michael ^a   Nagel, Stefan ^a   Wussow, Anke ^b   Peiser, Christian ^a   Fischer, Axel ^a   Schmitt, Roland ^a   Groneberg, David A ^a,b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Furosemide; Isolated kidney; Perfusion; Pig; Renal function

Indexed keywords

FUROSEMIDE; SODIUM;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL ANIMAL; EXPERIMENTAL MODEL; KIDNEY FUNCTION; KIDNEY PERFUSION; MAMMAL; MICTURITION; NONHUMAN; OXYGEN CONSUMPTION; SODIUM EXCRETION; SODIUM URINE LEVEL; SWINE;

EID: 0037607762     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10383     Document Type: Article

References (35)

1. Reach G, Nakane H, Nakane Y, Auzan C, Corvol P. 1977. Cortisol metabolism and excretion in the isolated perfused rat kidney. Steroids 30:621-635.
2. Bishop MC, Ross BD. 1978. Evaluation of hypertonic citrate flushing solution for kidney preservation using the isolated perfused rat kidney. Transplantation 25:235-239.
3. Cailleaux S, Lopes-Martins RA, Aimbire F, Cordeiro RS, Tibirica E. 1999. Involvement of platelet-activating factor in the modulation of vascular tone in the isolated perfused rabbit kidney. Naunyn Schmiedebergs Arch Pharmacol 359:505-511.
4. Maack T. 1980. Physiological evaluation of the isolated perfused rat kidney. Am J Physiol 238: F71-F78.
5. Kohrmann KU, Back W, Bensemann J, Florian J, Weber A, Kahmann F, Rassweiler J, Alken P. 1994. The isolated perfused kidney of the pig: New model to evaluate shock wave-induced lesions. J Endourol 8:105-110.
6. Goujon JM, Hauet T, Menet E, Levillain P, Babin P, Carretier M. 1999. Histological evaluation of proximal tubule cell injury in isolated perfused pig kidneys exposed to cold ischemia. J Surg Res 82:228-233.
7. Romano G, Favret G, Federico E, Bartoli E. 1998. The site of action of furosemide. Pharmacol Res 37:409-419.
8. Frodin L. 1975. Renal transplantation in the rat. II. In vitro perfusion of rat kidneys before transplantation. Scand J Clin Lab Invest 35:455-462.
9. Schurek HJ, Aulbert E, Ebel H. 1976. The effect of Ca ion antagonist verapamil on ouabain inhibition of renal sodium reabsorption. Studies in the isolated perfused rat kidney. Curr Probl Clin Biochem 6:281-290.
10. Raymond SL, Pert JH, Dodds WJ. 1975. Evaluation of platelet cryopreservation techniques by isolated kidney perfusion. Transfusion 15:219-225.
11. Vanherweghem JL, Ducobu J, d'Hollander A, Toussaint C. 1976. Effects of hypercalcemia on water and sodium excretion by the isolated dog kidney. Pflugers Arch 363:75-80.
12. Misumi J, Alhenc-Gelas F, Marre M, Marchetti J, Corvol P, Menard J. 1983. Regulation of kallikrein and renin release by the isolated perfused rat kidney. Kidney Int 24:58-65.
13. Loutzenhiser R, Epstein M, Horton C, Hamburger R. 1985. Nitrendipine-induced stimulation of renin release by the isolated perfused rat kidney. Proc Soc Exp Biol Med 180:133-136.
14. Adal Y, Pratt L, Comper WD. 1994. Transglomerular transport of DEAE dextran in the isolated perfused kidney. Microcirculation 1:169-174.
15. Kugler AR, Olson SC, Smith DE. 1995. Disposition of quinapril and quinaprilat in the isolated perfused rat kidney. J Pharmacokinet Biopharm 23:287-305.
16. Sawai K, Mahato RI, Oka Y, Takakura Y, Hashida M. 1996. Disposition of oligonucleotides in isolated perfused rat kidney: Involvement of scavenger receptors in their renal uptake. J Pharmacol Exp Ther 279:284-290.
17. Dittrich S, Schuth A, Aurich H, vonLoeper J, Grosse-Siestrup C, Lange PE. 2000. Haemodilution improves organ function during normothermic cardiopulmonary bypass: Investigations in isolated perfused pig kidneys. Perfusion 15:225-229.
18. Hauet T, Goujon JM, Tallineau C, Carretier M, Eugene M. 1999. Early evaluation of renal reperfusion injury after prolonged cold storage using proton nuclear magnetic resonance spectroscopy. Br J Surg 86:1401-1409.
19. Hauet T, Mothes D, Goujon J, Germonville T, Caritez JC, Carretier M, Eugene M, Tillement J. 1998. Trimetazidine reverses deleterious effects of ischemia-reperfusion in the isolated perfused pig kidney model. Nephron 80:296-304.
20. Hauet T, Tallineau C, Goujon JM, Carretier M, Eugene M, Tillement JP. 1998. Efficiency of trimetazidine in renal dysfunction secondary to cold ischemia-reperfusion injury: A proposed addition to University of Wisconsin solution. Cryobiology 37:231-244.
21. Hauet T, Faure JP, Baumert H, Bardou A, Gibelin H, Beguinot S, Germonville T, Hebrard W, Choulet P, Carretier M, Eugene M. 1998. Influence of different colloids on hemodynamic and renal functions: Comparative study in an isolated perfused pig kidney model. Transplant Proc 30:2796-2797.
22. Merkens LS, Cohen JJ, Peterson OW, Zamlauski MJ, Gregg CM, Black AJ. 1978. Tissue K+ loss from the perfused rat kidney: Effects of lactate and albumin treatment. Am J Physiol 235:F228-F233.
23. 2 and lactate in the perfused rat kidney. Am J Physiol 238:F415-F427.
24. Schurek HJ, Alt JM. 1981. Effect of albumin on the function of perfused rat kidney. Am J Physiol 240: F569-F576.
25. Gyrd-Hansen N. 1969. The effects of diuretics on renal clearances in pigs. Acta Vet Scand 10:345-358.
26. Shaw SM, Kessler WV, Christian JE. 1965. Investigation of the saluretic and kaliuretic properties of a diuretic agent in swine by in vivo whole body counting. J Pharm Sci 54:1208-1210.
27. Joppich R, Weyer P, Eife R. 1995. Effects of furosemide, captopril and indometacin on the renin-angiotensin system and the renal prostaglandins in anesthetized neonatal piglets. Arzneimittelforschung 45:822-825.
28. Harving N, Christiansen P, Taagehoj-Jensen F, Frokjaer J, Djurhuus JC, Mortensen J. 1991. Experimental evaluation of furosemide renography in unobstructed and partially obstructed upper urinary tracts in pigs. Urology 37:590-594.
29. Noordewier B, Bailie MD, Hook JB. 1980. Effect of furosemide on renal function of the newborn piglet. Pediatr Pharmacol (New York) 1:113-120.
30. Sjostrom PA, Kron BG, Odlind BG. 1993. Changes in renal clearance of furosemide due to changes in renal blood flow and plasma albumin concentration. Eur J Clin Pharmacol 45:135-139.
31. Breimer ME, Svalander CT, Haraldsson B, Bjorck S. 1996. Physiological and histological characterisation of a pig kidney in vitro perfusion model for xenotransplantation studies. Scand J Urol Nephrol 30:213-221.
32. Noordewier B, Bailie MD, Hood JB. 1978. Pharmacological analysis of the action of diuretics in the newborn pig. J Pharmacol Exp Ther 207:236-242.
33. Hauet T, Gibelin H, Richer JP, Godart C, Eugene M, Carretier M. 2000. Influence of retrieval conditions on renal medulla injury: Evaluation by proton NMR spectroscopy in an isolated perfused pig kidney model. J Surg Res 93:1-8.
34. Hauet T, Mothes D, Goujon JM, Caritez JC, Carretier M, Eugene M. 1997. Evaluation of injury preservation in pig kidney cold storage by proton nuclear magnetic resonance spectroscopy of urine. J Urol 157:1155-1160.
35. Hauet T, Gibelin H, Godart C, Eugene M, Carretier M. 2000. Kidney retrieval conditions influence damage to renal medulla: Evaluation by proton nuclear magnetic resonance (NMR) pectroscopy. Clin Chem Lab Med 38:1085-1092.