Ancestral processes for non-neutral models of complex diseases

Theoretical Population Biology

Volumn 63, Issue 2, 2003, Pages 115-130

  Fearnhead, Paul ^a  

^a LANCASTER UNIVERSITY   (United Kingdom)

Author keywords

Ancestral influence graph; Ancestral selection graph; Complex diseases; Gene interaction; Genic selection; Linkage disequilibrium

Indexed keywords

DISEASE; GENEALOGY; POPULATION GENETICS; SELECTION;

ARTICLE; BIOLOGICAL MODEL; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETIC RECOMBINATION; HAPLOIDY; HUMAN; PEDIGREE; POPULATION GENETICS; UNITED KINGDOM;

GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; GREAT BRITAIN; HAPLOIDY; HUMANS; LINKAGE DISEQUILIBRIUM; MODELS, GENETIC; PEDIGREE; RECOMBINATION, GENETIC;

EID: 0037606177     PISSN: 00405809     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-5809(02)00049-7     Document Type: Article

References (19)

1. Cordell H.J., Todd J.A., Hill N.J., Lyons P.A., Peterson L.B., Wicker L.S., Clayton D.G. Statistical modeling of interlocus interactions in a complex disease. rejection of the multiplicative model of epistasis in type 1 diabetes Genetics. 158:2001;357-367.
2. Donnelly P., Kurtz T. Genealogical processes for Fleming-Viot models with selection and recombination. Ann. Appl. Probab. 9:1999;1091-1148.
3. Fearnhead P. Perfect simulation from population genetic models with selection. Theoret. Popul. Biol. 59:2001;263-279.
4. Fearnhead, P., 2002. Haplotypes: the joint distribution of alleles at linked loci. J. Appl. Probab., submitted (Available from http://www.maths.lancs. ac.uk/~fearnhea/ ).
5. Griffiths R.C., Marjoram P. Ancestral inference from samples of DNA sequences with recombination. J. Comput. Biol. 3:1996;479-502.
6. Griffiths R.C., Marjoram P. An ancestral recombination graph. Donnelly P., Tavaré S. IMA Volume on Mathematical Population Genetics. 1996;257-270 Springer, Berlin.
7. Griffiths R.C., Tavaré S. Ancestral inference in population genetics. Statist. Sci. 9:1994;307-319.
8. Hartl D.L., Clark A.G. Principles of Population Genetics. 1997;Singauer Associates Inc, Sunderland, MA.
9. Hudson R.R. Gene genealogies and the coalescent process. Futuyma D., Antonovics J. Oxford Surveys in Evolutionary Biology. Vol. 7:1990;1-44 Oxford University Press, New York.
10. Kingman J.F.C. The coalescent. Stochastic Processes Appl. 13:1982;235-248.
11. Krone S.M., Neuhauser C. Ancestral processes with selection. Theoret. Popul. Biol. 51:1997;210-237.
12. Neuhauser C., Krone S.M. The genealogy of samples in models with selection. Genetics. 145:1997;519-534.
13. Niu T.H., Xu X.P., Cordell H.J., Rogus J., Zhou Y.S., Fang Z., Lindpaintner K. Linkage analysis of candidate genes and gene-gene interactions in Chinese hypertensive sib pairs. Hypertension. 33:1999;1332-1337.
14. Pritchard J.K. Are rare variants responsible for susceptibility to complex diseases? Am. J. Human Genet. 69:2001;124-137.
15. Propp J.G., Wilson D.B. Exact sampling with coupled Markov chains and applications to statistical mechanics. Random Struct. Algorithms. 9:1996;223-252.
16. Risch N. Linkage strategies for genetically complex traits. I. Multilocus models. Am. J. Human Genet. 46:1990;222-228.
17. Risch N., Merikangas K. The future of genetics studies of complex human diseases. Science. 273:1996;1516-1517.
18. Wiesch D.G., Meyers D.A., Bleecker E.R. Genetics of asthma. J. Allergy Clin. Immunol. 104:1999;895-901.
19. Wright S. Adaption and selection. Jepson G.L., Simpson G.G., Mayr E. Genetics, Paleontology and Evolution. 1949;365-389 Princeton University Press, Princeton, NJ.