Is low serum bilirubin an independent risk factor for coronary artery disease in men but not in women?

Clinical Chemistry

Volumn 49, Issue 7, 2003, Pages 1201-1204

  Endler, Georg ^a   Hamwi, Ahmad ^a   Sunder Plassmann, Raute ^a   Exner, Markus ^a   Vukovich, Thomas ^a   Mannhalter, Christine ^a   Wojta, Johann ^a   Huber, Kurt ^a   Wagner, Oswald ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; BILIRUBIN;

ADULT; AGED; ANALYTIC METHOD; ANAMNESIS; ARTICLE; BILIRUBIN BLOOD LEVEL; BIOASSAY; BLOOD SAMPLING; BODY MASS; CALCULATION; CARDIOMYOPATHY; CARDIOVASCULAR RISK; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONFIDENCE INTERVAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; DIABETES MELLITUS; FAMILY HISTORY; FEMALE; HEART ARRHYTHMIA; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PATIENT REFERRAL; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; RISK ASSESSMENT; RISK FACTOR; SEX DIFFERENCE; SMOKING; ST SEGMENT DEPRESSION; STATISTICAL SIGNIFICANCE; VALVULAR HEART DISEASE;

AGED; BILIRUBIN; CORONARY ARTERIOSCLEROSIS; FEMALE; HUMANS; MALE; MIDDLE AGED; RISK FACTORS; SEX FACTORS;

EID: 0037596761     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/49.7.1201     Document Type: Article

References (18)

1. Yamaguchi T, Terakado M, Horio F, Aoki K, Tanaka M, Nakajima H. Role of bilirubin as an antioxidant in an ischemia-reperfusion of rat liver and induction of heme oxygenase. Biochem Biophys Res Commun 1996;223:129-35.
2. Siow RC, Sato H, Mann GE. Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide? Cardiovasc Res 1999;41:385-94.
3. Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science 1987;235:1043-6.
4. Mayer M. Association of serum bilirubin concentration with risk of coronary artery disease. Clin Chem 2000;46:1723-7.
5. Schwertner HA, Jackson WG, Tolan G. Association of low serum concentration of bilirubin with increased risk of coronary artery disease. Clin Chem 1994;40:18-23.
6. Hopkins PN, Wu LL, Hunt SC, James BC, Vincent GM, Williams RR. Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease. Arterioscler Thromb Vasc Biol 1996;16:250-5.
7. Madhavan M, Wattigney WA, Srinivasan SR, Berenson GS. Serum bilirubin distribution and its relation to cardiovascular risk in children and young adults. Atherosclerosis 1997;131:107-13.
8. Breimer LH, Wannamethee G, Ebrahim S, Shaper AG. Serum bilirubin and risk of ischemic heart disease in middle-aged British men. Clin Chem 1995;41:1504-8.
9. Djousse L, Levy D, Cupples LA, Evans JC, D'Agostino RB, Ellison RC. Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study. Am J Cardiol 2001;87:1196-200.
10. Hunt SC, Kronenberg F, Eckfeldt JH, Hopkins PN, Myers RH, Heiss G. Association of plasma bilirubin with coronary heart disease and segregation of bilirubin as a major gene trait: the NHLBI family heart study. Atherosclerosis 2001;154:747-54.
11. Watanabe T, Akutsu Y, Yamanaka H, Michihata T, Okazaki O, Katagiri T, et al. Exercise-induced ST-segment depression: imbalance between myocardial oxygen demand and myocardial blood flow. Acta Cardiol 2000;55:25-31.
12. Harris TJ, Cook DG, Wicks PD, Cappuccio FP. Impact of the new American Diabetes Association and World Health Organisation diagnostic criteria for diabetes on subjects from three ethnic groups living in the UK. Nutr Metab Cardiovasc Dis 2000;10:305-9.
13. Wahlefeld AW, Herz G, Bernt E. Modification of the Malloy-Evelyn method for a simple; reliable determination of total bilirubin in serum [Abstract]. Scand J Clin Lab Invest 1972;29(Suppl):126.
14. Walden CE, Knopp RH, Johnson JL, Heiss G, Wahl PW, Hoover JJ. Effect of estrogen/progestin potency on clinical chemistry measures. The Lipid Research Clinics Program Prevalence Study. Am J Epidemiol 1986:123:517-31.
15. Luquita MG, Catania VA, Pozzi EJ, Veggi LM, Hoffman T, Pellegrino JM, et al. Molecular basis of perinatal changes in UDP-glucuronosyltransferase activity in maternal rat liver. J Pharmacol Exp Ther 2001;298:49-56.
16. Freeman R. Hormone replacement therapy (estrogen and progesterone): is it necessary for heart disease prevention? Prev Cardiol 2000;3:21-3.
17. Schwertner HA. Association of smoking ahd low serum bilirubin antioxidant concentrations. Atherosclerosis 1998;136:383-7.
18. Schwertner HA, Fischer JR Jr. Comparison of various lipid, lipoprotein, and bilirubin combinations as risk factors for predicting coronary artery disease. Atherosclerosis 2000;150:381-7.