Neoplastic transformation is not the cause of extremely long (more than 100 weeks) hematopoiesis maintenance of long-term bone marrow culture from TNF-deficient mice

Hematology Journal

Volumn 4, Issue 1, 2003, Pages 74-77

  Ershler, Maxim A ^a   Nifontova, Irina N ^a   Olshanskaya, Yulia V ^a   Todria, Tamara V ^a   Chertkov, Joseph L ^a   Drize, Nina J ^a  

^a NATIONAL RESEARCH CENTER FOR HEMATOLOGY   (Russian Federation)

Author keywords

Apoptosis; Differentiation; Long term bone marrow culture; Neoplastic transformation; Telomerase activity; TNF deficient mice

Indexed keywords

TELOMERASE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ADHERENT CELL; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOGENETICS; ENZYME ACTIVITY; FEMALE; GENETIC STABILITY; GENOME ANALYSIS; HEMATOPOIESIS; MALE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; TUMOR DIFFERENTIATION; ANEUPLOIDY; ANIMAL; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; C57BL MOUSE; CELL ADHESION; CELL CULTURE; CELL DIVISION; CLONOGENIC ASSAY; CYTOLOGY; GENETICS; MOUSE MUTANT; RADIATION CHIMERA; TIME; TRANSPLANTATION;

ANEUPLOIDY; ANIMALS; APOPTOSIS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL ADHESION; CELL DIFFERENTIATION; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; FEMALE; HEMATOPOIESIS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID CELLS; RADIATION CHIMERA; TELOMERASE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037591387     PISSN: 14664860     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.thj.6200203     Document Type: Article

References (19)

1. Marino MW, Dunn A, Grail D, Inglese M, Noguchi Y, Richards E et al. Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci USA 1997; 94: 8093-8098.
2. Pasparakis M, Alexopoulou L, Episkopou V, Kollias G. Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med 1996; 184: 1397-1411.
3. Jacobsen SE, Ruscetti FW, Dubois CM, Keller JR. Tumor necrosis factor alpha directly and indirectly regulates hematopoietic progenitor cell proliferation: role of colony-stimulating factor receptor modulation. J Exp Med 1992; 175: 1759-1772.
4. Rusten LS, Jacobsen FW, Lesslauer W, Loetscher H, Smeland EB, Jacobsen SE. Bifunctional effects of tumor necrosis factor alpha (TNF alpha) on the growth of mature and primitive human hematopoietic progenitor cells: involvement of p55 and p75 TNF receptors. Blood 1994; 83: 3152-3159.
5. Snoeck HW, Weekx S, Moulijn A, Lardon F, Lenjou M, Nys G et al. Tumor necrosis factor alpha is a potent synergistic factor for the proliferation of primitive human hematopoietic progenitor cells and induces resistance to transforming growth factor beta but not to interferon gamma. J Exp Med 1996; 183: 705-710.
6. Rogers JA, Berman JW. TNF-alpha inhibits the further development of committed progenitors while stimulating multipotential progenitors in mouse long-term bone marrow cultures. J Immunol 1994; 153: 4694-4703.
7. Shieh JH, Peterson RH, Warren DJ, Moore MA. Modulation of colony stimulating factor-1 receptors on macrophages by tumor necrosis factor. J Immunol 1989; 143: 2534-2539.
8. Elbaz O, Budel LM, Hoogerbrugge H, Touw IP, Delwel R, Mahmoud LA et al. Tumor necrosis factor downregulates granulocyte-colony-stimulating factor receptor expression on human acute myeloid leukemia cells and granulocytes. J Clin Invest 1991; 87: 838-841.
9. Jacobsen FW, Dubois CM, Rusten LS, Veiby OP, Jacobsen SE. Inhibition of stem cell factor-induced proliferation of primitive murine hematopoietic progenitor cells signaled through the 75-kilodalton tumor necrosis factor receptor. Regulation of c-kit and p53 expression. J Immunol 1995; 154: 3732-3741.
10. Durig J, de Wynter EA, Kasper C, Cross MA, Chang J, Testa NG et al. Expression of macrophage inflammatory protein-1 receptors in human CD34(+) hematopoietic cells and their modulation by tumor necrosis factor-alpha and interferon-gamma. Blood 1998; 92: 3073-3081.
11. Drize NI, Drutskaya MS, Gerasimova LP, Manakova TE, Chertkov IL, Turetskaya RL et al. Changes in the hemopoietic system of mice deficient for tumor necrosis factor or lymphotoxin-alpha. Bull Exp Biol Med 2000; 130: 676-678.
12. Drutskaya MS, Kuprash DV, Nedospasov SA, Chertkov IL, Drize NI. Abnormal hemopoiesis in long-term bone marrow culture from tumor necrosis factor-deficient mice. Bull Exp Biol Med 2001; 131: 150-152.
13. Dexter TM, Allen TD, Lajtha LG. Conditions controlling the proliferation of haemopoietic stem cells in vitro. J Cell Physiol 1977; 91: 335-344.
14. Drize NJ, Olshanskaya YV, Gerasimova LP, Manakova TE, Samoylina NL, Todria TV et al. Lifelong hematopoiesis in both reconstituted and sublethally irradiated mice is provided by multiple sequentially recruited stem cells. Exp Hematol 2001; 29: 786-794.
15. Todriia TV, Drize NI, Chertkov IL, Grimm I, Zander A. Telomerase activity in the mouse bone marrow and subpopulations of spleen colony-forming units. Bull Exp Biol Med 1999; 127: 311-313.
16. Hotz MA, Gong J, Traganos F, Darzynkiewicz Z. Flow cytometric detection of apoptosis: comparison of the assays of in situ DNA degradation and chromatin changes. Cytometry 1994; 15: 237-244.
17. Kopnin BP. Targets of oncogenes and tumor suppressors: key for understanding basic mechanisms of carcinogenesis. Biochemistry (Mosc) 2000; 65: 2-27.
18. Nifontova IN, Ershler MA, Drize NJ. Abnormalities of long-term bone marrow culture of TNF deficient mice: induction of apoptosis and cell proliferation. Bull Exp Biol Med 2002; 133: 445-448.
19. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414: 105-111.