Cholesterol and interkeukin-6 concentrations relate to outcomes in burn-injured patients

Journal of Burn Care and Rehabilitation

Volumn 24, Issue 3, 2003, Pages 133-141

  Colwell Vanni, Holly E ^a   Gordon, Bruce R ^a   Levine, Daniel M ^a,b   Sloan, Betty Jane ^a   Stein, David R ^a   Yurt, Roger W ^b   Saal, Stuart D ^a   Parker, Thomas S ^a,b  

^a ROGOSIN INSTITUTE   (United States)

^b WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROTEIN P55; PROTEIN P75; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR RECEPTOR; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BURN; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; DISEASE SEVERITY; FEMALE; HUMAN; INFECTION; LENGTH OF STAY; MALE; PREDICTION; SURVIVAL; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL; AGED; BLOOD; HOSPITALIZATION; METABOLISM; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; STATISTICS; TIME; UNITED STATES;

ADULT; AGED; BURNS; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; FEMALE; HUMANS; INTERLEUKIN-2; INTERLEUKIN-6; LENGTH OF STAY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEW YORK CITY; PROGNOSIS; RECEPTORS, TUMOR NECROSIS FACTOR; SEVERITY OF ILLNESS INDEX; SURVIVAL ANALYSIS; TIME FACTORS; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037572394     PISSN: 02738481     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.BCR.0000066812.96811.28     Document Type: Article

References (44)

1. Winchurch RA, Thupari JN, Munster AM. Endotoxemia in burn patients: levels of circulating endotoxins are related to burn size. Surgery 1987;102:808-12.
2. Endo S, Inada K, Kikuchi M, et al. Are plasma endotoxin levels related to burn size and prognosis? Burns 1992;18: 486-9.
3. Gallay P, Heumann D, Le Roy D, Barras C, Glauser MP. Lipopolysaccharide-binding protein as a major plasma protein responsible for endotoxemic shock. Proc Natl Acad Sci USA 1993;90:9935-8.
4. Schumann RR, Leong SR, Flaggs GW, et al. Structure and function of lipopolysaccharide binding protein. Science 1990;249:1429-31.
5. Tobias PS, Soldau K, Ulevitch RJ. Identification of a lipid A binding site in the acute phase reactant lipopolysaccharide binding protein. J Biol Chem 1989;264:10867-71.
6. Wright SD, Ramos RA, Tobias PS, et al. CD 14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990;249:1431-3.
7. Kruger C, Schutt C, Obertacke U, et al. Serum CD14 levels in polytraumatized and severely burned patients. Clin Exp Immunol 1991;85:297-301.
8. Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature 2000;406:782-7.
9. Yeh FL, Lin WL, Shen HD. Changes in circulating levels of an anti-inflammatory cytokine interleukin-10 in burned patients. Burns 2000;26:454-9.
10. Peteiro-Cartelle FJ, Alvarez-Jorge A. Dynamic profiles of interleukin-6 and the soluble form of CD 25 in burned patients. Burns 1999;25:487-91.
11. Endo S, Inada K, Yamada Y, et al. Plasma tumour necrosis factor-alpha (TNF-α) levels in patients with burns. Burns 1993;19:124-7.
12. Yamada Y, Endo S, Inada K. Plasma cytokine levels in patients with severe burn injury - with reference to the relationship between infection and prognosis. Burns 1996;22: 587-93.
13. Mathison JC, Wolfson E, Ulevitch RJ. Participation of tumor necrosis factor in the mediation of gram-negative bacterial lipopolysaccharide-induced injury in rabbits. J Clin Invest 1988;81:1925-37.
14. Cavaillon JM, Fitting C, Haeffner-Cavaillon N, et al. Cytokine response by monocytes and macrophages to free and lipoprotein-bound lipopolysaccharide. Infect Immunol 1990;58:2375-82.
15. Baumberger C, Ulevitch RJ, Dayer JM. Modulation of endotoxic activity of lipopolysaccharide by high-density lipoprotein. Pathobiology 1991;59:378-83.
16. Gordon BR, Parker TS, Levine DM, et al. Low lipid concentrations in critical illness: implications for preventing and treating endotoxemia. Crit Care Med 1996;24:584-9.
17. Hubsch AP, Powell FS, Lerch PG, Doran JE. A reconstituted, apolipoprotein A-I containing lipoprotein reduces tumor necrosis factor release and attenuates shock in endotoxemic rabbits. Circ Shock 1993;40:14-23.
18. Levine DM, Parker TS, Donnelly TM, Walsh A, Rubin AL. In vivo protection against endotoxin by plasma high density lipoprotein. Proc Natl Acad Sci USA 1993;90:12040-4.
19. Pajkrt D, Lerch PG, van der Poll T, et al. Differential effects of reconstituted high-density lipoprotein on coagulation, fibrinolysis and platelet activation during human endotoxemia. Thromb Haemost 1997;77:303-7.
20. Pajkrt D, Doran JE, Koster F, et al. Anti-inflammatory effects of reconstituted high-density lipoprotein during human endotoxemia. J Exp Med 1996;184:1601-8.
21. Verdery RB, Goldberg AP. Hypocholesterolemia as a predictor of death: a prospective study of 224 nursing home residents. J Gerontol 1991;46:M84-90.
22. Noel MA, Smith TK, Ettinger WH. Characteristics and outcomes of hospitalized older patients who develop hypocholesterolemia. J Am Geriatr Soc 1991;39:455-61.
23. Schatz IJ, Masaki K, Yano K, Chen R, Rodriguez BL, Curb JD. Cholesterol and all-cause mortality in elderly people from the Honolulu Heart Program: a cohort study. Lancet 2001; 358:351-5.
24. Weverling-Rinjsburger AW, Blauw GJ, Lagaay AM, Knook DL, Meinders AE, Westendorp RG. Total cholesterol and risk of mortality in the oldest old. Lancet 1997;350: 1119-23.
25. Gordon BR, Parker TS, Levine DM, et al. Relationship of hypolipidemia to cytokine concentrations and outcomes in critically ill surgical patients. Crit Care Med 2001;29: 1563-8.
26. Coombes EJ, Shakespeare PG, Batstone GF. Lipoprotein changes after burn injury in man. J Trauma 1980;20:971-5.
27. Baxter CR, Shires T. Physiologic response to crystalloid resuscitation of severe burns. Ann NY Acad Sci 1968;150: 874-94.
28. Yurt R. Burns. In: Norton JA, Bollinger RR, Chang AE, et al, editors. Surgery: basic science and clinical evidence. New York: Springer-Verlag; 2001.
29. Peck MD, Weber J, McManus A, Sheridan R. Heimbach D. Surveillance of burn wound infections: a proposal for definitions. J Burn Care Rehabil 1998;19:386-9.
30. Zawacki BE, Azen SP, Imbus SH, Chang YT. Multifactorial probit analysis of mortality in burned patients. Ann Surg 1979;189:1-5.
31. Ryan CM, Schoenfeld DA, Thorpe WP, Sheridan RL, Cassem EH, Tompkins RG. Objective estimates of the probability of death from burn injuries. N Engl J Med 1998;338: 362-6.
32. Muller MJ, Pegg SP, Rule MR. Determinants of death following burn injury. Br J Surg 2001;88:583-7.
33. Fraunberger P, Pilz G, Cremer P, Werdan K, Walli AK. Association of serum tumor necrosis factor levels with decrease of cholesterol during septic shock. Shock 1998;10:359-63.
34. Spriggs DR, Sherman ML, Michie H, et al. Recombinant human tumor necrosis factor administered as a 24-hour intravenous infusion. A phase I and pharmacologic study. J Natl Cancer Inst 1988;80:1039-44.
35. van Gameren MM, Willemse PH, Mulder NH, et al. Effects of recombinant human interleukin-6 in cancer patients: a phase I-II study. Blood 1994;84:1434-41.
36. Ettinger WH, Varma VK, Sorci-Thomas M, et al. Cytokines decrease apolipoprotein accumulation in medium from HEP G2 cells. Arterioscler Thromb 1994;14:8-13.
37. Tietge UJ, Maugeais C, Cain W, et al. Overexpression of secretory phospholipase A(2) causes rapid catabolism and altered tissue uptake of high density lipoprotein cholesteryl ester and apolipoprotein A-I. J Biol Chem 2000;275: 10077-84.
38. Panousis CG, Zuckerman SH. Interferon-gamma induces down regulation of Tangier disease gene (ATP-binding-cassette transporter 1) in macrophage-derived foam cells. Arterioscler Thromb Vasc Biol 2000;20:1565-71.
39. Feingold KR, Staprans I, Memon RA, et al. Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance. J Lipid Res 1992;33:1765-76.
40. Carter EA, Tompkins RG. Injury-induced inhibition of fat absorption. J Burn Care Rehab 1994;15:154-7.
41. Bang R, Sharma PN, Gang RK, Ghoneim IE, Ebrahim MK. Burn mortality during 1982 to 1997 in Kuwait. Eur J Epidemiol 2000;16:731-9.
42. Sheridan RL, Ryan CM, Yin LM, Hurley J, Tompkins RG. Death in the burn unit: sterile multiple organ failure. Burns 1998;24:307-11.
43. Ulevitch RJ, Johnston AR, Weinstein DB. New function for high density lipoproteins. Isolation and characterization of a bacterial lipopolysaccharide-high density lipoprotein complex formed in rabbit plasma. J Clin Invest 1981;67:827-37.
44. Nieuwenhuijzen GA, Goris RJ. The gut: the 'motor' of multiple organ dysfunction syndrome? Curr Opin Clin Nutr Metab Care 1999;2:399-404.