Acute zonisamide overdose: A death revisited

Veterinary and Human Toxicology

Volumn 45, Issue 3, 2003, Pages 154-156

  Sztajnkrycer, Matthew D ^a   Huang, E E ^a   Bond, G R ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; BENZODIAZEPINE DERIVATIVE; CAFFEINE; CARBAMAZEPINE; DIPHENHYDRAMINE; MIRTAZAPINE; PHENYTOIN; VALPROIC ACID; ZONISAMIDE;

ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DRUG OVERDOSE; DRUG SCREENING; FEMALE; HUMAN; IMAGE ANALYSIS; SUICIDE ATTEMPT;

ADOLESCENT; ANTICONVULSANTS; ARRHYTHMIA; CARDIOPULMONARY RESUSCITATION; DIAGNOSIS, DIFFERENTIAL; ELECTROCARDIOGRAPHY; FATAL OUTCOME; FEMALE; HUMANS; INTRACRANIAL HEMORRHAGES; ISOXAZOLES; OVERDOSE; SUICIDE, ATTEMPTED; TOMOGRAPHY, X-RAY COMPUTED;

EID: 0037572142     PISSN: 01456296     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Peters DH, Sorkin EM: Zonisamide: A review of its Pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy. Drugs 45: 760-787, 1993.
2. White HS: Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs. Epilepsia 40 (Suppl): S2-S10, 1999.
3. Product Information: Zonegran®, zonisamide. Ela Pharmaceuticals, San Francisco, CA, 2000.
4. Wilensky AJ, Friel PN, Ojemann LM et al: Zonisamide in epilepsy: A pilot study. Epilepsia 26: 212-220, 1985.
5. Kanba S, Yagi G, Kamijima K et al: The first open study of zonisamide, a novel anticonvulsant, shows efficacy in mania. Prog Neuro-Psychopharmacol Biol Psychiat 18: 707-715, 1994.
6. Naito H, Itoh N, Matsui N et al: Monitoring plasma concentrations of zonisamide and clonazepam in an epileptic attempting suicide by an overdose of the drugs. Curr Ther Res 43: 463-467, 1988.
7. Leppik IE: Zonisamide. Epilepsia 40 (Suppl): S23-S29, 1999.
8. Kito M, Maihara M, Watanabe K: Mechanisms of T-type calcium channel bloackade by zonisamide. Seizure 5: 115-119, 1996.
9. Okada M, Kaneko S, Hirano T et al: Effects of zonisamide on dopaminergic system. Epilepsy Res 22: 193-205, 1995.
10. 2+ dependent dopamine release. Epilepsy Res 13: 111-119, 1992.
11. Mori A, Noda Y, Packer L: The anticonvulsant zonisamide scavenges free radicals. Epilepsy Res 30: 153-158, 1998.
12. Perucca E, Bialer M: The clinical pharmacokinetics of the newer antiepileptic drugs. Clin Pharmacokinet 31: 29-46, 1996.
13. Oommen KJ, Mathews S: Zonisamide: A new antiepileptic drug. Clin Neuropharmacol 22: 192-200, 1999.
14. Mimaki T: Clinical pharmacology and therapeutic drug monitoring of zonisamide. Ther Drug Monit 20: 593-597, 1998.
15. Nakasa H, Komiya M, Ohmori S et al: Characterization of human liver microsomal cytochrome P450 involved in the reductive metabolism of zonisamide. Mol Pharmacol 44: 216-221, 1993.
16. Leppik IE, Willmore LJ, Homan RW et al: Efficacy and safety of zonisamide: Results of a multicenter study. Epilepsy Res 14: 165-173, 1993.
17. Akaho R: The effects of antiepileptic drugs on cognition in normal volunteers. Psychiatr Clin Neurosci 50: 61-69, 1996.
18. Shimizu T, Yamashita Y, Satoi M et al: Heat stroke-like episode in a child caused by zonisamide. Brain Dev 19: 366-368, 1997.
19. Manoguerra A, Hurlburt KM: Mirtazepine, Poisindex. Micromedex ® Healthcare Series. Vol 115, 3/2003.
20. Retz W, Maier S, Maris F et al: Non-fatal mirtazapine overdose. Int Clin Psychopharmacol 13: 277-279, 1998.
21. th Ed. McGraw-Hill New York: 535-543, 2002.
22. th Ed. McGraw-Hill, New York: 578-592, 2002.