Double-stranded RNA activates a p38 MAPK-dependent cell survival program in biliary epithelia

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 284, Issue 6 47-6, 2003, Pages

  Tadlock, Laura ^a   Yamagiwa, Yoko ^a   Marienfeld, Carla ^a   Patel, Tushar ^a  

^a SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

Author keywords

Apoptosis; Caspase; Cholangiocyte; Mitogen activated protein kinase; Protein kinase R

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CAMPTOTHECIN; CASPASE 3; CASPASE 8; CASPASE 9; DOUBLE STRANDED RNA; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; GENOTOXICITY; HEPATOBILIARY SYSTEM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS REPLICATION;

EID: 0037572072     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00355.2002     Document Type: Article

References (25)

1. Barber GN, Thompson S, Lee TG, Strom T, Jagus R, Darveau A, and Katze MG. The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties. Proc Natl Acad Sci USA 91: 4278-4282, 1994.
2. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, and Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498, 2001.
3. Gale, M Jr, Kwieciszewski B, Dossett M, Nakao H, and Katze MG. Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase. J Virol 73: 6506-6516, 1999.
4. Geiss G, Jin G, Guo J, Bumgarner R, Katze MG, and Sen GC. A comprehensive view of regulation of gene expression by double-stranded RNA-mediated cell signaling. J Biol Chem 276: 30178-30182, 2001.
5. Gil J and Esteban M. Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action. Apoptosis 5: 107-114, 2000.
6. Haruna Y, Kanda T, Honda M, Takao T, and Hayashi N. Detection of hepatitis C virus in the bile and bile duct epithelial cells of hepatitis C virus-infected patients. Hepatology 33: 977-980, 2001.
7. Iordanov MS, Pribnow D, Magun JL, Dinh TH, Pearson JA, and Magun BE. Ultraviolet radiation triggers the ribotoxic stress response in mammalian cells. J Biol Chem 273: 15794-15803, 1998.
8. Iordanov MS, Wong J, Bell JC, and Magun BE. Activation of NF-κB by double-stranded RNA (dsRNA) in the absence of protein kinase R and RNase L demonstrates the existence of two separate dsRNA-triggered antiviral programs. Mol Cell Biol 21: 61-72, 2001.
9. Jacobs BL and Langland JO. When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA. Virology 219: 339-349, 1996.
10. Kaufman RJ. Double-stranded RNA-activated protein kinase mediates virus-induced apoptosis: a new role for an old actor. Proc Natl Acad Sci USA 96: 11693-11695, 1999.
11. Kawai HF, Koji T, Iida F, Kaneko S, Kobayashi K, and Nakane PK. Shift of hepatitis E virus RNA from hepatocytes to biliary epithelial cells during acute infection of rhesus monkey. J Viral Hepat 6: 287-297, 1999.
12. Kobayashi M, Ikeda K, Saitoh S, Suzuki F, Tsubota A, Suzuki Y, Arase Y, Murashima N, Chayama K, and Kumada H. Incidence of primary cholangiocellular carcinoma of the liver in Japanese patients with hepatitis C virus-related cirrhosis. Cancer 88: 2471-2477, 2000.
13. Korth MJ and Katze MG. Evading the interferon response: hepatitis C virus and the interferon-induced protein kinase, PKR. Curr Top Microbiol Immunol 242: 197-224, 2000.
14. Kumar A, Haque J, Lacoste J, Hiscott J, and Williams BR. Double-stranded RNA-dependent protein kinase activates transcription factor NF-κB by phosphorylating IκB. Proc Natl Acad Sci USA 91: 6288-6292, 1994.
15. Nakagawa N, Ikoma J, Ishihara T, Yasui-Kawamura N, Fujita N, Iwasa M, Kaito M, Watanabe S, and Adachi Y. Biliary excretion of TT virus (TTV). J Med Virol 61: 462-467, 2000.
16. Park H, Davies MV, Langland JO, Chang HW, Nam YS, Tartaglia J, Paoletti E, Jacobs BL, Kaufman RJ, and Venkatesan S. TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR. Proc Natl Acad Sci USA 91: 4713-4717, 1994.
17. Park J, Gores GJ, and Patel T. Lipopolysaccharide induces cholangiocyte proliferation via an interleukin-6-mediated activation of p44/p42 mitogen-activated protein kinase. Hepatology 29: 1037-1043, 1999.
18. Park J, Tadlock L, Gores GJ, and Patel T. Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line. Hepatology 30: 1128-1133, 1999.
19. Tadlock L and Patel T. Involvement of p38 mitogen-activated protein kinase signaling in transformed growth of a cholangiocarcinoma cell line. Hepatology 33: 43-51, 2001.
20. Tan SL and Katze MG. The emerging role of the interferon-induced PKR protein kinase as an apoptotic effector: a new face of death? J Interferon Cytokine Res 19: 543-554, 1999.
21. Terada T, Ueyama J, Ukita Y, and Ohta T. Protein expression of double-stranded RNA-activated protein kinase (PKR) in intrahepatic bile ducts in normal adult livers, fetal livers, primary biliary cirrhosis, hepatolithiasis and intrahepatic cholangiocarcinoma. Liver 20: 450-457, 2000.
22. Tornaletti S and Hanawalt PC. Effect of DNA lesions on transcription elongation. Biochimie 81: 139-146, 1999.
23. Williams BR. PKR: a sentinel kinase for cellular stress. Oncogene 18: 6112-6120, 1999.
24. Wu S, Rehemtulla A, Gupta NK, and Kaufman RJ. A eukaryotic translation initiation factor 2-associated 67 kDa glycoprotein partially reverses protein synthesis inhibition by activated double-stranded RNA-dependent protein kinase in intact cells. Biochemistry 35: 8275-8280, 1996.
25. Yeung MC and Lau AS. Tumor suppressor p53 as a component of the tumor necrosis factor-induced, protein kinase PKR-mediated apoptotic pathway in human promonocytic U937 cells. J Biol Chem 273: 25198-25202, 1998.