Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis

British Journal of Surgery

Volumn 90, Issue 6, 2003, Pages 680-686

  Murphy, G J ^a,b   Waller, J R ^a   Sandford, R S ^a   Furness, P N ^a   Nicholson, M L ^a  

^a LEICESTER GENERAL HOSPITAL   (United Kingdom)

^b DERRIFORD HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN A; LOW DENSITY LIPOPROTEIN; STEROID; TACROLIMUS; ACETYLSALICYLIC ACID; COTRIMOXAZOLE; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; NIFEDIPINE; PREDNISOLONE;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHRONIC ALLOGRAFT NEPHROPATHY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DIABETES MELLITUS; DRUG BLOOD LEVEL; DRUG DOSE; DRUG EFFECT; DRUG FATALITY; DRUG FORMULATION; FEMALE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; GRAFT REJECTION; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; INSULIN RESISTANCE; KIDNEY BIOPSY; KIDNEY DISEASE; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MICROEMULSION; MORPHOMETRICS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; STAINING; STATISTICAL SIGNIFICANCE; ANALYSIS OF VARIANCE; EXTRACELLULAR MATRIX; FIBROSIS; GRAFT SURVIVAL; METABOLISM; PATHOLOGY; TREATMENT OUTCOME;

ADULT; ANALYSIS OF VARIANCE; ASPIRIN; CYCLOSPORINE; EXTRACELLULAR MATRIX; FEMALE; FIBROSIS; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; NIFEDIPINE; PREDNISOLONE; PROSPECTIVE STUDIES; TACROLIMUS; TREATMENT OUTCOME; TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION;

EID: 0037562574     PISSN: 00071323     EISSN: None     Source Type: Journal    
DOI: 10.1002/bjs.4134     Document Type: Article

References (21)

1. Cecka JM. The UNOS Scientific Renal Transplant Registry. Clin Transpl 1999; 13: 1-21.
2. Paul LC. Chronic allograft nephropathy: an update. Kidney Int 1999; 56: 783-793.
3. Johnson C, Ashan N, Gonwa T, Halloran P, Stegall M, Hardy M et al. Randomized trial of tacrolimus (Prograt) in combination with azathioprine or mycophenolate mofetil versus cyclosporine (Neoral®) with mycophenolate mofetil after cadaveric kidney transplantation. Transplantation 2000; 69: 834-841.
4. Yang HC, Hohnan MJ, Langhoff E, Ulsh PJ, Dellock CA, Gupta M et al. Tacrolimus/'low dose' mycophenolate mofetil versus microemulsion cyclosporine/'low dose' mycophenolate mofetil after kidney transplantation - 1-year follow-up of a prospective randomized clinical trial. Transplant Proc 1999; 31: 1121-1124.
5. Morris-Stiff GJ, Quiroga I, Stockdill H, Jones G, Janeciz A, Lord R et al. Randomized trial of Prograf versus Neoral® in cadaveric renal transplantation: 189 patients with a minimum 1-year follow-up. Br J Surg 2000; 87(Suppl 1): 30 (Abstract).
6. Jurewicz WA. Immunological and nonimmunological risk factors with tacrolimus and Neoral® in renal transplant recipients: an interim report. Transplant Proc 1999; 31: 64S-66S.
7. Nicholson ML, Bailey E, Williams S, Harris KP, Furness PN. Computerized histomorphometric assessment of protocol renal transplant biopsy specimens for surrogate markers of chronic rejection. Transplantation 1999; 68: 236-241.
8. Nicholson ML, Bailey E, Williams S, Harris KP, Furness PN. Renal allograft survival can be predicted by histomorphometric assessment of extracellular matrix in 6-month protocol biopsies. Transplant Proc 1998; 30: 1305-1306.
9. Moreso F, Gratin C, Vitria J, Condom E, Poveda R, Cruzado JM et al. Automatic evaluation of renal interstitial volume fraction. Transplant Proc 1995; 27: 2231-2232.
10. Solez E, Axelsen RA, Benediktsson H, Burdick AF, Cohen AH, Colvin RB et al. International standardization of criteria for the histologic diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology. Kidney Int 1993; 44: 411-422.
11. Radermacher J, Meiners M, Bramlage C, Kleim V, Behrend M, Schlitr HJ et al. Pronounced renal vasoconstriction and systemic hypertension in renal transplant patients treated with cvclosporin A versus FK 506. Transplant Int 1998; 11: 3-10.
12. Mayer AD, Dmitrewski J, Squifflet JP, Besse T, Grabensee B, Klein B et al. Multicenter randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of renal allograft rejection: a report of the European Tacrolimus Multicenter Renal Study Group. Transplantation 1997; 64: 436-443.
13. Kobashigawa JA, Kasiske BL. Hyperlipidemia in solid organ transplantation. Transplantation 1997; 63: 331-338.
14. Dimeny E, Fellstrom B, Larsson E, Wahlberg J, Lithell H. The role of lipoprotein abnormalities in chronic vascular rejection after kidney transplantation. Transplant Proc 1995; 27: 2036-2039.
15. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witzum JL. Beyond cholesterol. Modification of low-density lipoprotein that increases its atherogenicity. N Engl J Med 1989; 320: 915-924.
16. Apanay DC, Neylan JF, Ragab MS, Sgoutas DS. Cyclosporine increases the oxidizability of low-density lipoproteins in renal transplant recipients. Transplantation 1994; 58: 663-669.
17. Pirsch JD, Miller J, Deierhoi MH, Vincent F, Filo RS. A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group. Transplantation 1997; 63: 977-983.
18. Mayer AD. Four-year follow-up of the European Tacrolimus Multicenter Renal Study. Transplant Proc 1999; 31: 27S-28S.
19. Jensik SC. Tacrolimus (FK506) in kidney transplantation: three year survival results of the US multicenter, randomized comparative trial. FK506 Kidney Transplant Study Group. Transplant Proc 1998; 30: 1216-1218.
20. Shapiro R, Scantlebury VP, Jordan ML, Vivas C, Ellis D, Lombarddozzi-Lane S et al. Pediatric renal transplantation under tacrolimus-based immunosuppression. Transplantation 1999; 67: 299-303.
21. Shapiro R, Jordan ML, Scantlebury VP, Vivas C, Marsh JW, McCauley J et al. A prospective, randomized trial of tacrolimus/prednisone versus tacrolimus/prednisone/ mycophenolate mofetil in renal transplant recipients. Transplantation 1999; 67: 411-415.