Osteoporosis in acute spinal cord injury

Topics in Spinal Cord Injury Rehabilitation

Volumn 9, Issue 1, 2003, Pages 26-35

  Chen, Bojun ^a   Stein, Adam ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

BMD; Bone loss; Hypercalcemia; Hypercalciuria; N telopeptide; Osteoporosis; PTH; SCI; Vitamin D

Indexed keywords

ALENDRONIC ACID; CALCITRIOL; CALCIUM CARBONATE; CLENBUTEROL; ETIDRONIC ACID; PAMIDRONIC ACID; TILUDRONIC ACID;

BONE METABOLISM; DISEASE ASSOCIATION; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; ELECTROSTIMULATION; HUMAN; HYPOCALCEMIA; MOBILIZATION; NEPHROLITHIASIS; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OSTEOPOROSIS; PATHOLOGIC FRACTURE; PATHOPHYSIOLOGY; PROPHYLAXIS; REVIEW; SPINAL CORD INJURY; ULTRASOUND THERAPY;

EID: 0037531611     PISSN: 10820744     EISSN: None     Source Type: Journal    
DOI: 10.1310/FQXJ-3D10-EP92-6LNV     Document Type: Review

References (80)

1. Roberts D, Lee W, Cuneo RC, et al. Longitudinal study of bone turnover after acute spinal cord injury. J Clin Endocrinol Metab. 1998;83:415-422.
2. Chen B, Mechanick, JI, Nierman, DM, Stein A. Combined calcitriol-pamidronate therapy for bone hyperresorption in spinal cord injury. J Spinal Cord Med. 2001;24:235-240.
3. Mechanick JI, Pomerantz F, Flanagan S, Stein A, Gordon WA, Ragnarsson K. Parathyroid hormone suppression in spinal cord injury patients is associated with the degree of neurologic impairment and not the level of injury. Arch Phys Med Rehabil. 1997;78:692-696.
4. Kearns PJ, Thompson JD, Werner PC, Pipp TL, Wilmot CB. Nutritional and metabolic response to acute spinal-cord injury. J Parenter Enteral Nutr. 1992;16:11-15.
5. Claus-Walker J, Halstead LS. Metabolic and endocrine changes in spinal cord injury: IV. Compounded neurologic dysfunctions. Arch Phys Med Rehabil. 1982;63:632-638.
6. Maynard FM. Immobilization hypercalcemia following spinal cord injury. Arch Phys Med Rehabil. 1986;67:41-44.
7. Nance PW, Schryvers O, Lexlie W, Ludwig S, Krahn J, Uebelhart D. Intravenous pamidronate attenuates bone density loss after acute spinal cord injury. Arch Phys Med Rehabil. 1999;80:243-251.
8. Kiratli BJ, Agre JC. Disuse osteoporosis in spinal cord injured patients. Rehabil Res Dev Progr Rep. 1990;425-426.
9. Ingram RR, Suman RK, Freeman PA. Lower limb fractures in the chronic spinal cord injured patient. Paraplegia. 1989;27:133-139.
10. Sobel M, Lyden JP. Long bone fracture in a spinal-cord-injured patient: complication of treatment - a case report and review of the literature. J Trauma. 1991;31:1440-1444.
11. Lazo MG, Shirazi P, Sam M, Giobbie-Hurder A, Blacconiere MJ, Muppidi M. Osteoporosis and risk of fracture in men with spinal cord injury. Spinal Cord. 2001;39:208-214.
12. Tori JA, Kewalramani LS, Orth MS. Urolithiasis in children with spinal cord injury. Paraplegia. 1978;16:357-365.
13. Stover SL, Niermann KM, Tulloss JR. Experience with surgical resection of heterotopic bone in spinal cord injury patients. Clin Orthop. 1991;263:71-77.
14. Bergmann P, Heilporn A, Schoutens A, Paternot J, Tricot A. Longitudinal study of calcium and bone: metabolism in paraplegic patients. Paraplegia. 1977-78;15:147-159.
15. Claus-Walker J, Carter RE, Campos RJ, Spencer WA. Hypercalcemia in early traumatic quadriplegia. J Chron Dis. 1975;28:81-90.
16. Chantraine A. Bone remodeling during the development of osteoporosis in paraplegia. Calcif Tissue Int. 1986;38:323-327.
17. Maynard FM, Imai K. Immobilization hypercalcemia in spinal cord injury. Arch Phys Med Rehabil. 1977;58:16-24.
18. Stewart AF, Adler M, Byers CM, Serge GV, Broadus AE. Calcium homeostasis in immobilization: an example or resorptive hypercalciuria. N Engl J Med. 1982;306:1136-1140.
19. Nand S, Goldschmidt JW. Hypercalcemia and hyperuricemia in young patients with spinal cord injury. Arch Phys Med Rehabil. 1976;57:553.
20. Steinberg FU, Birge SJ, Cooke NE. Hypercalcemia in adolescent tetraplegia patients: case report and review. Paraplegia. 1978;16:60-67.
21. Tori JA, Hill LL. Hypercalcemia in children with spinal cord injury. Arch Phys Med Rehabil. 1978;59:443-447.
22. Minaire P, Meunier P, Edouard C, Bernard J, Courpron P, Bourret J. Quantitative histological data on disuse osteoporosis. Calcif Tiss Res. 1974;17:57-73.
23. Claus-Walker J, Spencer WA, Carter RE, Halstead LS, Meier RH III, Campos RJ. Bone metabolism in quadriplegia: dissociation between calciuria and hydroxyprolinuria. Arch Phys Med Rehabil. 1975;54:327-332.
24. Claus-Walker J, Campos RJ, Carter RE, Vallbona C, Lipscomb HS. Calcium excretion in quadriplegia. Arch Phys Med Rehabil. 1972;53:14-21.
25. Heaney RP. Radiocalcium metabolism in disuse osteoporosis in man. Am J Med. 1962;33:188-200.
26. Claus-Walker J, Carter RE, Campos RJ, Spencer WA. Sitting muscular exercises, and collagen metabolism in tetraplegia. Am J Phys Med. 1979;58:285-293.
27. Lipton A, Demers L, Curley E, et al. Markers of bone resorption in patients treated with pamidronate. Euro J Cancer. 1998;34:2021-2026.
28. Ebeling PR, Atley LM, Guthrie JR, et al. Bone turnover markers and bone density across the menopausal transition. J Clin Endocrinol Metab. 1996;81:3366-3371.
29. Rosen HN, Dresner-Pollak R, Moses AC, et al. Specificity of urinary excretion of cross-linked N-telopeptides of type I collagen as markers of bone turnover in humans. Calcif Tissue Int. 1994;54:26-29.
30. Schneider DL, Barrett-Connor EI. Urinary N-telopeptide levels discriminate normal, osteopenic, and osteoporotic bone mineral density. Arch Int Med. 1997;157:1241-1245.
31. Frey-Rindova P, de Bruin ED, Stussi E, Dambacher MA, Dietz V. Bone mineral density in upper and lower extremities during 12 months after spinal cord injury measured by peripheral quantitative computed tomography. Spinal Cord. 2000;38:26-32.
32. Vaziri ND, Pandian MR, Segal JL, Winer RL, Eltorai I, Brunnemann S. Vitamin D, parathyroid hormone, and calcitonin profiles in persons with long-standing spinal cord injury. Arch Phys Med Rehabil. 1994;75:766-769.
33. Shetty KR, Sutton CH, Mattson DE, Rudman D. Hyposomatomedinemia in quadriplegic men. Am J Med Sci. 1993;305:95-100.
34. Nierman DM, Mechanick JI. Bone hyperresorption is prevalent in chronically critically ill patients. Chest. 1998;114:1122-1128.
35. Johnston CC, Slemenda CW, Melton J. Clinical use of bone densitometry. N Engl J Med. 1991; 324:1105-1109.
36. Peck WA, Burckhardt P, et al. Consensus development conference: diagnosis, prophylaxis and treatment of osteoporosis. Am J Med. 1993;94:646-650.
37. Warden SJ, Bennell KL, Matthews B, Brown DJ, McMeeken JM, Wark JD, Wark JD. Quantitative ultrasound assessment of acute bone loss following spinal cord injury: a longitudinal pilot study. Osteoporos Int. 2002;13:586-592.
38. Liu CC, Theodorou DJ, Theodorou SJ, et al. Quantitative computed tomography in the evaluation of spinal osteoporosis following spinal cord injury. Osteoporos Int. 2000;11:889-896.
39. Chow YW, Inman C, Pollintine P, Sharp CA, Haddaway MJ, el Masry W, Davie MW. Ultrasound bone densitometry and dual energy X-ray absorptiometry in patients with spinal cord injury: a cross-sectional study. Spinal Cord. 1996;34:736-741.
40. Szollar SM, Martin EM, Parthemore JG, Sartoris DJ, Deftos LJ. Demineralization in tetraplegic and paraplegic men over time. Spinal Cord. 1997;35:223-228.
41. Jaovisidha S, Sartoris DJ, Martin EM, De Maeseneer M, Szollar SM, Deftos LJ. Influence of spondylopathy on bone densitometry using dual energy X-ray absorptiometry. Calcif Tissue Int. 1997;60:424-429.
42. Jones LM, Goulding A, Gerrard DF. DEXA: a practical and accurate tool to demonstrate total and regional bone loss, lean tissue loss and fat mass gain in paraplegia. Spinal Cord. 1998;36:637-640.
43. Tsuzuku S, Ikegami Y, Yabe K. Bone mineral density differences between paraplegic and quadriplegic patients: a cross-sectional study. Spinal Cord. 1999;37:358-361.
44. Dauty M, Perrouin Verbe B, Maugars Y, Dubois C, Mathe JF. Supralesional and sublesional bone mineral density in spinal cord-injured patients. Bone. 2000;27:305-309.
45. Garland DE, Stewart CA, Adkins RH, et al. Osteoporosis after spinal cord injury. J Orthop Res. 1992;10:371-378.
46. Maimoun L, Couret I, Micallef JP, et al. Use of bone biochemical markers with dual-energy X-ray absorptiometry for early determination of bone loss in persons with spinal cord injury. Metabolism. 2002;51:958-963.
47. Chantraine A. Actual concept of osteoporosis in paraplegia. Paraplegia. 1978-79;16:51-58.
48. Griffiths HJ, Bushueff B, Zimmerman RE. Investigation of the loss of bone mineral in patients with spinal cord injury. Paraplegia. 1976;14:207-212.
49. Garland DE, Adkins RH, Stewart CA, Ashford R, Vigil D. Regional osteoporosis in women who have a complete spinal cord injury. J Bone Joint Surg Am. 2001;83A:1195-1200.
50. Bauman WA, Spungen AM. Metabolic changes in persons after spinal cord injury. Phys Med Rehabil Clin N Am. 2000;11:109-140.
51. Gallacher SJ, Ralston SH, Dryburgh FJ, et al. Immobilization-related hypercalcemia - a possible novel mechanism and response to pamidronate. Postgrad Med J. 1990;66:918-922
52. Saltzstein RJ, Hardin S, Hastings J. Osteoporosis in spinal cord injury: using an index of mobility and its relationship to bone density. J Am Paraplegia Soc. 1992;15:232-234.
53. Kunkel CF, Scremin AME, Eisenberg B, Garcia JF, Roberts S, Martinez S. Effect of "standing" on spasticity, contracture, and osteoporosis in paralyzed males. Arch Phys Med Rehabil. 1993;74:73-78.
54. Hyman LR, Boner G, Thomas JC, Segar WE. Immobilization hypercalcemia. Am J Dis Child. 1972;124:723-727.
55. Suzuki Y, Nagase Y, Kawase M, et al. Prevention of bone loss in overiectomized rats by pulsatile transdermal iontophoretic administration of human PTH (1-34). J Pharm Sci. 2002;91:350-361.
56. Ragab AA, Nalepka JL, Bi Y, Greenfield EM. Cytokines synergistically induce osteoclast differentiation: support by immortalized of normal calvarial cells. Am J Physiol Cell Physiol. 2002;283:C679-687.
57. Kanatani M, Sugimoto T, Kano J, Chihara K. IGF-I mediates the stimulatory effect of high phosphate concentration on osteoblastic cell proliferation. J Cell Physiol. 2002;190:306-312.
58. Hayes KC, Hull TC, Delaney GA, Potter PJ, Sequeira KA, Campbell K, Popovich PG. Elevated serum titers of proinflammatory cytokines and CNS autoantibodies in patients with chronic spinal cord injury. J Neurotrauma. 2002;19:753-761.
59. Garland DE, Foulkes G, Adkins RH, et al. Regional osteoporosis following incomplete spinal cord injury. Contemp Orthop. 1994;28:134-138.
60. Ragnarsson KT, Sell GH. Lower extremity fractures after spinal cord injury: a retrospective study. Arch Phys Med Rehabil. 1981;62:418-423.
61. De Bruin ED, Frey-Rindova P, Herzog RE, Dietz V, Dambacher MA, Stussi E. Changes of tibia bone properties after spinal cord injury: effects of early intervention. Arch Phys Med Rehabil. 1999;80:214-220.
62. Rodgers MM, Glaser RM, Figoni SF, et al. Musculoskeletal responses of spinal cord injured individuals to functional neuromuscular stimulation-induced knee extension exercise training. J Rehabil Res Dev. 1991;28:19-26.
63. Petrofsky JS, Phillips CA. The use of functional electrical stimulation for rehabilitation of spinal cord injured patients. Cent Nerv Syst Trauma. 1984;1:57-74.
64. Lee YH, Rah JH, Park RW, Park CI. The effect of early therapeutic electrical stimulation on bone mineral density in the paralyzed limbs of the rabbit. Yonsei Med J. 2001;42:194-198.
65. Needham-Shropshire BM, Broton JG, Klose KJ, Lebwoho N, Guest RS, Jacobs PL. Evaluation of a training program for persons with SCI paraplegia usingthe Parastep 1 ambulation system: part 3. Lack of effect on bone mineral density. Arch Phys Med Rehabil. 1997;78:799-803.
66. BeDell KK, Scremin AM, Perell KL, Kunkel CF. Effects of functional electrical stimulation-induced lower extremity cycling on bone density of spinal cord-injured patients. Am J Phys Med Rehabil. 1996;75:29-34.
67. Belanger M, Stein RB, Wheeler GD, Gordon T, Leduc B. Electrical stimulation: Can it increase muscle strength and reverse osteopenia in spinal cord injured individuals? Arch Phys Med Rehabil. 2000;81:1090-1098.
68. Mohr T, Podenphant J, Biering-Sorensen F, Galbo H, Thamsborg G, Kjaer M. Increased bone mineral density after prolonged electrically induced cycle training of paralyzed limbs in spinal cord injured man. Calcif Tissue Int. 1997;61:22-25.
69. Ralston SH, Gallacher SJ, Patel U, et al. Comparison of three intravenous bisphosphonates in cancer-associated hypercalcemia. Lancet. 1989;2:1180-1182.
70. Licata AA. Therapies for symptomatic primary osteoporosis. Geriatrics. 1991;46:62-67.
71. Mallette LE, Leblanc AD, Pool JL, Mechanick JI. Cyclic therapy of osteoporosis with neutral phosphate and brief high-dose pulses of etidronate. J Bone Min Res. 1989;4:143-148.
72. Carey PO, Lippert MC. Treatment of painful prostatic bone metastases with oral etidronate disodium. Urology. 1988;32:403-407.
73. Siris ES. Perspectives: a practical guide to the use of pamidronate in the treatment of Paget's disease. J Bone Min Res. 1994;9:303-304.
74. Pearson E, Nance PW, Leslie WD, Ludwig S. Cyclical etidronate: its effect on bone density in patients with acute spinal cord injury. Arch Phys Med Rehabil. 1997;78:269-272.
75. Astrom E, Slderhall S. Beneficial effect of long term intravenous bisphosphonate treatment of osteogenesis imperfecta. Arch Dis Child. 2002;86:356-364.
76. Sniger W, Garshick E. Alendronate increases bone density in chronic spinal cord injury: a case report. Arch Phys Med Rehabil. 2002;83:139-140.
77. Chappard D, Minaire P, Privat C, et al. Effects of tiludronate on bone loss in paraplegic patients. J Bone Min Res. 1995;10:112-118.
78. Warden SJ, Bennell KL, Matthews B, Brown DJ, McMeeden JM, Wark JD. Efficacy of low-intensity pulsed ultrasound in the prevention of osteoporosis following spinal cord injury. Bone. 2001;29:431-436.
79. Garland DE, Adkins RH, Matsuno NN, Stewart CA. The effect of pulsed electromagnetic fields on osteoporosis at the knee in individuals with spinal cord injury. J Spinal Cord Med. 1999;22:239-245.
80. Zeman RJ, Hirschman A, Hirschman ML, Guo G, Etlinger JD. Clenbuterol, a beta 2-receptor agonist, reduces net bone loss in denervated hindlimbs. Am J Physiol. 1991;261:E285-289.