Bifunctional constructs of aspirin and ibuprofen (non-steroidal anti-inflammatory drugs; NSAIDS) that express antibacterial and alkylation activities

Biotechnology and Applied Biochemistry

Volumn 37, Issue 3, 2003, Pages 273-282

  Bartzatt, Ronald ^a   Cirillo, Suat L G ^b   Cirillo, Jeffrey D ^b   Donigan, Laura ^a  

^a UNIVERSITY OF NEBRASKA AT OMAHA   (United States)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

Antibacterial; Anticancer; Aspirin; Cytotoxic; Ibuprofen; Tripeptide

Indexed keywords

ALKYLATION; DNA SEQUENCES; ESCHERICHIA COLI; ESTERS; REACTION KINETICS;

ANTI-INFLAMMATORY DRUGS;

DRUG PRODUCTS;

2 [BIS(2 CHLOROETHYL)AMINO]ETHANOL; 4 CHLOROANILINE; ACETYLSALICYLIC ACID; CHLORMETHINE DERIVATIVE; DRUG CARRIER; FLUORESCAMINE; GLYCYL DEXTRO ALANYL DEXTRO ALANINE; IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; PENICILLIN DERIVATIVE; TRIPEPTIDE; UNCLASSIFIED DRUG;

ALKYLATION; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCULATION; CHEMICAL COMPOSITION; DRUG ACTIVITY; DRUG HYDROLYSIS; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; NONHUMAN; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS, ALKYLATING; ASPIRIN; CELL DIVISION; CROSS-LINKING REAGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG DELIVERY SYSTEMS; ESCHERICHIA COLI; IBUPROFEN; NITROGEN MUSTARD COMPOUNDS;

ESCHERICHIA COLI;

EID: 0037498430     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20020108     Document Type: Article

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