Furoyl and benzofuroyl pyrroloquinolones as potent and selective PDE5 inhibitors for treatment of erectile dysfunction

Journal of Medicinal Chemistry

Volumn 46, Issue 3, 2003, Pages 441-444

  Jiang, Weiqin ^a   Sui, Zhihua ^a   Macielag, Mark J ^a   Walsh, Shawn P ^a   Fiordeliso, James J ^a   Lanter, James C ^a   Guan, Jihua ^a   Qiu, Yuhong ^a   Kraft, Patricia ^a   Bhattacharjee, Sheela ^a   Craig, Elizabeth ^a   Haynes Johnson, Donna ^a   John, T Matthew ^a   Clancy, Joanna ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOFURAN DERIVATIVE; ISOENZYME; PHOSPHODIESTERASE I; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; PYRROLOQUINOLINEQUINONE; SILDENAFIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; ERECTILE DYSFUNCTION; MALE; NONHUMAN; PENIS ERECTION; RAT; STRUCTURE ACTIVITY RELATION;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; BIOLOGICAL AVAILABILITY; CELL LINE; CYCLIC GMP; DOGS; FURANS; IMPOTENCE; ISOENZYMES; MALE; PENILE ERECTION; QUINOLONES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037472832     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0202573     Document Type: Article

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