Aberrant caspase-activated DNase (CAD) transcripts in human hepatoma cells

British Journal of Cancer

Volumn 88, Issue 2, 2003, Pages 210-216

  Hsieh, S Y ^a,b   Liaw, S F ^a,c   Lee, S N ^c   Hsieh, P S ^a   Lin, K H ^b   Chu, C M ^a   Liaw, Y F ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Caspase activated DNase; DFF; DFF B; DNA fragmentation factor; Hepatocellular carcinoma

Indexed keywords

CASPASE; DEOXYRIBONUCLEASE;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CHROMOSOME; CONTROLLED STUDY; EXON; GENE MAPPING; GENE MUTATION; HEPATOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKOCYTE; LIVER; LIVER CARCINOGENESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; TRANSCRIPTION INITIATION;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL DIFFERENTIATION; DEOXYRIBONUCLEASES; DISEASE PROGRESSION; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE DELETION; HUMANS; LEUKOCYTES; LIVER NEOPLASMS; MOLECULAR SEQUENCE DATA; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR CELLS, CULTURED;

EID: 0037468118     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600695     Document Type: Article

References (44)

1. Ars E, Serra E, Garcia J, Kruyer H, Gaona A, Lazaro C, Estivill X (2000) Mutations affecting mRNA splicing are the most common molecular defects in patients with neurofibromatosis type 1. Hum Mol Genet 9: 237- 247
2. Barrack ER (1996) Androgen receptor mutations in prostate cancer. Mt Sinai J Med 63: 403-412
3. Blencowe BJ (2000) Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases. Trends Biochem Sci 25: 106-110
4. Buetow KH, Murray JC, Israel JL, London WT, Smith M, Kew M, Blanquet V, Brechot C, Reder A, Govindarajah S (1989) Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma. Proc Natl Acad Sci, USA 86: 8852-8856
5. Chang KSS, Hsu MI, Josphs SF (1993) Regulation of HIV-1 LTR transactivating activities in two different human hepatocellular carcinoma cell ines. Cancer Lett 74: 75- 83
6. Chen MR, Hsu TY, Chou MJ, Chang ACW, Chen JY, Yang CS (1994) Stability of HBV DNA in cell lines and nude mouse-passaged tissues derived from human hepatocellular carcinoma. Chinese J Microbiol Immunol 27: 1-12
7. Cooper DL, Dougherty GJ (1995) To metastasize or not? Selection of CD44 splice sites. Nature Med 1:635-637
8. Coulter LR, Landree MA, Cooper TA (1997) Identification of a new class of exonic splicing enhancers by in vivo selection. Mol Cell Biol 17: 2143-2150
9. Croft L, Schandorff S, Clark F, Burrage K, Arctander P, Mattick JS (2000) ISIS, the intron information system, reveals the high frequency of alternative splicing in the human genome. Nat Genet 24: 340-341
10. Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata SA (1998) caspase-activated DNase that degrades DNA during apoptosis and its inhibitor ICAD. Nature 391: 43-50
11. Fogh J, Fogh J, Orfeo T (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J Natl Cancer Inst 59: 221-225
12. Halenbeck R, MacDonald H, Roulston A, Chen TT, Conroy L, Williams LT (1998) CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45. Curr Biol 8: 537-540
13. Hastings ML, Krainer AR (2001) Pre-mRNA splicing in the new millennium. Curr Opin Cell Biol 13: 302-309
14. Hsieh SY, Meng XJ, Wu YH, Liu ST, Tam AW, Lin DY, Liaw YF (1999) Identity of a novel swine hepatitis E virus in Taiwan forming a monophyletic group with Taiwan isolates of human hepatitis E virus. J Clin Microbiol 37: 3828-3834
15. Hsieh SY, Yang PY, Chen HC, Liaw YF (1997) Cloning and characterization of the extreme 5′-terminal sequences of the RNA genomes of GB virus C/hepatitis G virus. Proc Natl Acad Sci, USA 94: 3206-3210
16. Inohara N, Koseki T, Chen S, Benedict MA, Nunez G (1999) Identification of regulatory and catalytic domains in the apoptosis nuclease DFF40/CAD. Journal of Biological Chemistry 274: 270-274
17. Iwase H, Omoto Y, Iwata H, Hara Y, Ando Y, Kobayashi S (1998) Genetic and epigenetic alterations of the estrogen receptor gene and hormone independence in human breast cancer. Oncology 55: 11-16
18. Kazazian Jr HH (1998) Mobile elements and disease. Curr Opin Genet Dev 8: 343-350
19. Lin CH, Hsieh SY, Sheen IS, Lee WC, Chen TC, Shyu WC, Liaw YF (2001) Genome-wide hypomethylation in hepatocellular carcinogenesis. Cancer Res 61: 4238-4243
20. Liu HX, Cargegni L, Zhang MQ, Krainer AR (2001) A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes. Nat Genet 27: 55-58
21. Liu X, Li P, Widlak P, Zou H, Luo X, Garrard WT, Wang X (1998) The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci, USA 95: 8461-8466
22. Liu X, Zou H, Slaughter C, Wang X (1997) DFF, a heterodimeic protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89: 175-184
23. Lugovskoy AA, Zhou P, Chou JJ, McCarty JS, Li P, Wagner G (1999) Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis. Cell 99: 747- 755
24. Mathias SL, Scott AF, Kazazian Jr HH, Boeke JD, Gabriel A (1991) Reverse transcriptase encoded by a human transposable element. Science 254: 1808-1810, 1991
25. Mironov AA, Fickett JW, Gelfand MS (1999) Frequent alternative splicing of human genes. Genome Res 9: 1288-1293
26. Mukae N, Enari M, Sakahira H, Fukuda Y, Inazawa J, Toh H, Nagata S (1998) Molecular cloning and characterization of human caspase-activated DNase. Proc Natl Acad Sci, USA 95:9123-9128
27. Muratani K, Hada T, Yamamoto Y, Kaneko T, Shigeto Y, Ohue T, Furuyama J, Higashimo K (1991) Inactivation of the cholinesterase gene by Alu insertion: possible mechanism for human gene transposition. Proc Natl Acad Sci USA 88: 11315-11319
28. Otomo T, Sakahira H, Uegaki K, Nagata S, Yamazaki T (2000) Structure of the heterodimeric complex between CAD domains of CAD and ICAD. Nat Structu Biol 7: 658-662
29. Pfeffer U (1996) Estrogen receptor mRNA variants. Do they have a physiological role? Ann NY Acad Sci 784: 304-311
30. Philips AV, Cooper TA (2000) RNA processing and human disease. Cell Mol Life Sci 57: 235-249
31. Sakahira H, Enari M, Nagata S (1998) Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391: 96-99
32. Sakahira H, Enari M, Nagata S (1999) Functional differences of two forms of the inhibitor of caspase-activated DNase, ICAD-L, and ICAD-S. J Biol Chem 274: 15740-15744
33. Sakahira H, Iwamatsu A, Nagata S (2000) Specific chaperone-like activity of inhibitor of caspase-activated DNase for caspase-activated DNase. J Biol Chem 275: 8091-8096
34. Savagner P, Valles AM, Jouanneau J, Yamada KM, Thiery JP (1994) Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells. Mol Biol Cell 5: 851-862
35. Simon D, Knowles BB, Weith A (1991) Abnormalities of chromosome 1 and loss of heterozygosity on 1p in primary hepatoma. Oncogene 6: 765-770
36. Skuse GR, Cappione AJ (1997) RNA processing and clinical variability in neurofibromatosis type 1 (NF1). Human Mol Genet 6: 1707-1712
37. Teraoka SN, Telatar M, Becker-Catania S, Liang T, Onengut S, Tolun A, Chessa L, Sanal O, Bernatomska E, Gatti RA, Concannon P (1999) Slicing defects in the ataxia-telangiectasia gene, ATM: underlying mutations and consequences. Am J Hum Genet 64: 1617-1631
38. Uegake K, Otomo T, Sakahira H, Shimizu M, Yumoto N, Kyogoku Y, Nagata S, Yamazaki T (2000) Structure of the CAD domain of caspase-activated DNase and interaction with the CAD domain of its inhibitor. J Mol Biol 297: 1121-1128
39. Vidaud D, Vidaud M, Bahnak BR, Siguret V, Gispert Sanchez S, Laurian Y, Meyer D, Goossens M, Lavergne JM (1993) Hemophilia B due to a de novo insertion of a human-specific Alu subfamily member within the coding region of the factor IX gene. Eur J Hum Genet 1: 30-36
40. Walllace MR, Andersen LB, Saulino AM, Gregory PE, Glover TW, Collins FS (1991) A de novo Alu insertion results in neurofibromatosis type 1. Nature 353: 864-866.
41. Wyllie AH (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284: 555-556
42. Yeh SH, Chen PJ, Chen MY, Lai MY, Wang CC, Chen DS (1994) Frequent genetic alternations at the distal region of chromosome 1p inhuman hepatocellular carcinomas. Cancer Res 54: 4188-4192
43. Zhang J, Liu X, Scherer DC, Kaer LV, Wang X, Xu M (1998) Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45. Proc Natl Acad Sci USA 95: 8461-8466
44. Zhou P, Lugovskoy AA, McCarty JS, Li P, Wagner G (2001) Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45. Proc Natl Acad Sci USA 98: 6051-6055