Development and validation of a liquid chromatography-tandem mass spectrometric assay for Eplerenone and its hydrolyzed metabolite in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 787, Issue 2, 2003, Pages 333-344

  Zhang, Ji Y ^a   Fast, Douglas M ^a   Breau, Alan P ^a  

^a PFIZER INC   (United States)

Author keywords

Eplerenone

Indexed keywords

BIOASSAY; FULLERENES; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES;

BLOOD PLASMA;

BLOOD;

ACETONITRILE; ALDOSTERONE ANTAGONIST; AMMONIUM ACETATE; DRUG METABOLITE; EPLERENONE; ISOTOPE; WATER;

ACCURACY; ARTICLE; ASSAY; AUTOMATION; CONTROLLED STUDY; DEVICE; DRUG BLOOD LEVEL; DRUG HYDROLYSIS; HUMAN; HUMAN EXPERIMENT; IONIZATION; MASS SPECTROMETER; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION; STANDARD; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEMOLYSIS; HUMANS; HYDROLYSIS; MASS SPECTROMETRY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPIRONOLACTONE;

EID: 0037466188     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(02)00964-9     Document Type: Article

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